Effect of biologically relevant ions on the corrosion products formed on alloy AZ31B: An improved understanding of magnesium corrosion

Jang, Yong-Seok; Collins, Boyce; Sankar, Jagannathan; Yun, Yeoheung

doi:10.1016/j.actbio.2013.03.026

Cited by 99 publications

(58 citation statements)

References 46 publications

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“…The majority of this research into Mg biocorrosion has been conducted via in vitro immersion tests [27][28][29][30][31][32][33][34][35][36][37][38][39].…”

Section: Medical Magnesium and Biocorrosionmentioning

confidence: 99%

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

2017

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The factors that influence magnesium (Mg) corrosion in vitro are systematically evaluated from a review of the relevant literature. We analysed the influence of the following factors on Mg biocorrosion in vitro: (i) inorganic ions, including both anions and cations, (ii) organic components such as proteins, amino acids and vitamins, and (iii) experimental parameters such as temperature, pH, buffer system and flow rate. Considerations and recommendations towards a standardised approach to in vitro biocorrosion testing are given. Several potential simulated body fluids are recommended. Implementing a standardised approach to experimental parameters has the potential to significantly reduce variability between in vitro biocorrosion tests, and to help build towards a methodology that accurately and consistently mimics in vivo corrosion. However, there are also knowledge gaps with regard to how best to characterise the in vivo environment and corrosion mechanism. The assumption that blood plasma is the correct bodily fluid upon which to base in vitro methodologies is examined, and factors that influence the corrosion mechanism in vivo, such as specimen encapsulation, bear consideration for further studies.

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“…The majority of this research into Mg biocorrosion has been conducted via in vitro immersion tests [27][28][29][30][31][32][33][34][35][36][37][38][39].…”

Section: Medical Magnesium and Biocorrosionmentioning

confidence: 99%

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

2017

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“…In skeletal environments, stress corrosion is frequently observed and can potentially lead to quick failure at generally safe loads [5]. Future studies will consider the potential for Mg to pick up particulates, which add to the volume over time [8]. These and other changes in geometry affect device behavior and will need to be considered using contact analysis.…”

Section: Discussionmentioning

confidence: 99%

“…There are numerous types of corrosion reported in the literature. Corrosion behavior depends heavily on the specific alloy and solutions used [7,8]. Stress corrosion is one specific form of corrosion that was not considered in this study.…”

Section: Discussionmentioning

confidence: 99%

Magnesium Modeling Using SolidWorks

McCullough

2015

Journal of Bone Biology and Osteoporosis

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Increased cost and complexity associated with orthopaedic surgeries has led to advancements in degradable materials. Degradable metals like magnesium have shown great promise as magnesium based alloys provide the strength of metals but the degradability of polymers. As the development of degradable magnesium alloys expands there is a significant need for simplified computational models that can account for the numerous mechanical changes associated with degradation. The current study examined initial in silico models of Magnesium samples to gain insight on how degradation impacts mechanical performance over time. Models of magnesium rods were created and analyzed using the finite element analysis functionality in a commercially available software package. SolidWorks is widely known for its design capabilities and generation of 3D solid models; however its analyses capabilities would be useful for such a smart material, like magnesium. Therefore, this work explores the analysis capabilities of SolidWorks, for degradable magnesium in a skeletal environment.

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“…These dynamic factors affect cell behavior, which is in contrast to the indirect culture system [62]. It is totally different from the natural dynamic bioenvironment in vivo [101], in which the stent is exposed to various organic [102] and inorganic [103] constituents, followed by a complex response of proteins, blood [104], cells [64] and tissue [46] and meanwhile the dynamic circulation system removes the degradation products and prevents a drift of local pH [101].…”

Section: Limitations Of Direct and Indirect Culture Assaysmentioning

confidence: 99%

“…Many studies indicated that extracts from Mg alloys have little or no effect on cell viability by utilizing the indirect culture assay [79,[105][106][107]. Similarly, it is obvious that the test system is static compared to in vivo condition as mentioned above [46,62,64,[101][102][103][104], that is, it cannot adapt to the changes in the environment of the degradable Mg-based stent as the human body does.…”

Section: Limitations Of Direct and Indirect Culture Assaysmentioning

confidence: 99%

In vitro and in vivo cytocompatibility evaluation of biodegradable magnesium-based stents: a review

et al. 2018

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Biodegradable magnesium (Mg)-based vascular stents have been designed as temporary scaffolds to treat angiostenotic lesions for the maintenance of normal blood flow. Numerous studies have presented in vitro and in vivo tests for the evaluation of the safety and feasibility of Mg-based vascular stents and the related materials. Therein the cytocompatibility is a basic and important parameter in the evaluation system. In this review, we summarize the applications and limitations of in vitro evaluation methods including basic characterization methods and direct and indirect cytotoxicity tests. We discuss the influencing factors on cytotoxicity, such as surface roughness, preconditioning of sample surface, cell type for the biocompatibility evaluation in direct contact as well as conditions for the formation of extracts/ degradation products for indirect assays. Besides, we highlight the recent in vivo animal tests and clinical trials about Mgbased stents along with some associated results. The aim of this review is to provide a meaningful reference in the further developments and related evaluation methods of Mg-based stents.

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Effect of biologically relevant ions on the corrosion products formed on alloy AZ31B: An improved understanding of magnesium corrosion

Cited by 99 publications

References 46 publications

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

Magnesium Modeling Using SolidWorks

In vitro and in vivo cytocompatibility evaluation of biodegradable magnesium-based stents: a review

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