Effect of benzodiazepines on structural and conceptual/lexical priming

Boucart, Muriel; Biederman, Irving; Cuervo, Christine; Danion, Jean-Marie; Wagemans, Johan

doi:10.1007/s00213-002-1243-7

Cited by 10 publications

(8 citation statements)

References 30 publications

(46 reference statements)

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“…In previous studies using a category generation task, Brown et al11 found conceptual priming to be suppressed with lorazepam, while Bishop and Curran17 reported that conceptual priming is preserved under lorazepam. And results on conceptual priming using a same-name exemplar test reported conceptual/lexical priming to be suppressed in participants administered with a single dose of lorazepam 42. The present experimental study did not find any differential effect of lorazepam compared to diazepam and placebo on conceptual priming at Day 2 of the experiment.…”

Section: Discussioncontrasting

confidence: 55%

Anti-Intrusion Effect of Lorazepam: An Experimental Study

Lee

et al. 2013

Psychiatry Investig

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ObjectiveEasy triggering of trauma-related episodic memory fragments caused by perceptual cues is tied to strong perceptual priming in the implicit memory system. And among benzodiazepines, only lorazepam has been consistently reported to have an atypical suppression effect on perceptual priming processes. The aim of this study was to investigate the effects of single doses of lorazepam, diazepam, and a placebo on intrusive memories after exposure to a distressing videotape and to explore whether the anti-intrusive effect of lorazepam is acquired as a result of the suppression of perceptual but not conceptual priming processes.MethodsUnder prospective, randomized, and double-blind conditions, we compared the anti-intrusion effect of a single dose of lorazepam (n=22) with that of diazepam (n=22) and a placebo (n=21) in young healthy Korean college students following exposure to a traumatic videotape.ResultsWe present the first finding for an anti-intrusion effect of lorazepam. One day after the medication, lorazepam, rather than diazepam or the placebo, significantly reduced the extent of intrusion and data-driven processing of the traumatic information. There were no differences among the three conditions in state anxiety, depression, and an arousal scale throughout the experiment.ConclusionResults from this study suggest the possibility of lorazepam as a candidate anti-intrusion drug, as well as the cautious use of diazepam in the treatment of PTSD patients. The anti-intrusive effect of lorazepam is directly related to its atypical inhibitory effect on implicit perceptual priming processes. The present study provides support for the enhanced perceptual priming hypothesis of PTSD.

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Section: Discussioncontrasting

confidence: 55%

Anti-Intrusion Effect of Lorazepam: An Experimental Study

Lee

et al. 2013

Psychiatry Investig

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“…More constrained situations could also explain previous effects of lorazepam in tests that involved identification of degraded pictures (e.g. Boucart et al 2002;Sellal et al, 1992;Vidailhet et al, 1994;Wagemans et al, 1998), an effect not observed here in the Gestalt Completion task in which subjects were exposed to all degraded pictures for 2 min and could concentrate on any of them for periods varying in length as they saw fit. Also, this task was found to be difficult even for placebo-treated subjects, so it can say little about the perceptual effects of lorazepam.…”

Section: Discussionmentioning

confidence: 59%

“…Thus, the dose of lorazepam used here was sufficiently high to elicit the classic BZ episodic memory effects, and has also been shown to atypically impair performance in perceptual implicit memory measures such as stem completion (Blin et al, 2001;Buffett-Jerrott et al, 1998;Pompéia et al, 2000Pompéia et al, , 2003aStewart et al, 1996;Thiel et al, 2001) and identification of degraded pictures (e.g. Boucart et al 2002;Sellal et al, 1992;Vidailhet et al, 1994;Wagemans et al, 1998). Whether the underlying mechanisms responsible for results in the Identical Pictures are related to the atypical visual perceptual effects of lorazepam (e.g.…”

Section: Discussionmentioning

confidence: 87%

Effects of lorazepam on visual perceptual abilities

Pompéia

Pradella-Hallinan

Manzano

et al. 2008

Human Psychopharmacology

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“…GABA A PAMs may reduce familiarity by attenuating semantic or implicit memory processes that are thought to support feelings of familiarity (Yonelinas, 2002; also see Wang et al, 2014; Davies et al, 2004). Although GABA A PAMs do not always affect implicit or semantic memory (for review, see Curran, 1999), there are some cases in which they can (e.g., Hirshman, Passannante, & Henzler, 1999; Stewart et al, 1996; Boucart et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Alcohol and pharmacologically similar sedatives impair encoding and facilitate consolidation of both recollection and familiarity in episodic memory

Doss

Weafer

Ruiz

et al. 2018

Cognitive Neuroscience

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Alcohol and other pharmacologically similar sedatives (i.e., GABA positive allosteric modulators or PAMs) impair the encoding of new episodic memories but retroactively facilitate the consolidation of recently encoded memories. These effects are consistent for recollection (i.e., the retrieval of details) but some mixed results have been reported for familiarity (i.e., a feeling of knowing a stimulus was presented). Here, with dual-process models, we reanalyzed prior work testing the effects of GABA PAMs at encoding or consolidation. Contrary to previous conclusions, we show that GABA PAMs at encoding consistently impair both recollection and familiarity when an independence correction is applied to familiarity-based responses. These findings were further confirmed and extended in a dual-process signal detection analysis of a recent study on the effects of alcohol during encoding or consolidation: Alcohol at encoding impaired both recollection and familiarity, whereas alcohol at consolidation enhanced both recollection and familiarity. These findings speak to the ability of alcohol and other GABA PAMs to induce 'blackouts,' highlighting the importance of dual-process approaches when analyzing drug manipulations at different phases of episodic memory.

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Effect of benzodiazepines on structural and conceptual/lexical priming

Cited by 10 publications

References 30 publications

Anti-Intrusion Effect of Lorazepam: An Experimental Study

Anti-Intrusion Effect of Lorazepam: An Experimental Study

Effects of lorazepam on visual perceptual abilities

Alcohol and pharmacologically similar sedatives impair encoding and facilitate consolidation of both recollection and familiarity in episodic memory

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