2017
DOI: 10.1590/0001-3765201720160050
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Effect of Bauhinia holophylla treatment in Streptozotocin-induced diabetic rats

Abstract: Bauhinia holophylla, commonly known as "cow's hoof", is widely used in Brazilian folk medicine for the diabetes treatment. Therefore, the aim of this study was at evaluating the aqueous extract effect of Bauhinia holophylla leaves treatment on the streptozotocin-induced diabetic rats. Diabetes was induced by Streptozotocin (40 mg/Kg) in female Wistar rats. Oral administration of aqueous extract of Bauhinia holophylla leaves was given to non-diabetic and diabetic rats at a dose of 400 mg/kg during 21 days. On d… Show more

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Cited by 20 publications
(15 citation statements)
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“…Despite the increased appetite, insulin deficit reduces all anabolic processes and increases catabolic processes, contributing to further body weight loss [33]. This biological condition was not observed in the present study, in contrast to previous studies using this diabetic model [32,34]. Perhaps the glycemic level, although high, was not sufficient to decrease the weight of these animals during the experimental period.…”
Section: Discussioncontrasting
confidence: 89%
See 1 more Smart Citation
“…Despite the increased appetite, insulin deficit reduces all anabolic processes and increases catabolic processes, contributing to further body weight loss [33]. This biological condition was not observed in the present study, in contrast to previous studies using this diabetic model [32,34]. Perhaps the glycemic level, although high, was not sufficient to decrease the weight of these animals during the experimental period.…”
Section: Discussioncontrasting
confidence: 89%
“…Nevertheless, the hyperglycemia and AUC were reduced in the rats with uncontrolled diabetes, confirming the effectiveness of the extract at reducing the blood glucose level. However, the plant did not reduce hyperglycemia to normal levels probably because of the severe diabetes status, which is characterized by severe hyperglycemia (glucose level greater than 300 mg/kg) [32]. Pereira et al [15] verified that the ethanolic H. speciosa extract (300 mg/ kg) exerted a potential anti-diabetic effect related to the inhibition of intestinal α-glucosidase activity and stimulation of glucose uptake by adipocytes.…”
Section: Discussionmentioning
confidence: 99%
“…citrate buffer. Tail blood glucose concentrations were measured using a One Touch Ultra glucometer (Johnson & Johnson ® ) 7 days after the STZ treatment and glucose concentrations exceeding 300 mg/dL confirmed the presence of diabetes [21]. …”
Section: Methodsmentioning
confidence: 99%
“…2004; Pinheiro et al. 2017). For example, a recent study evaluating the hypoglycaemic potential of B. holophylla , a species used in folk medicine to treat diabetes (Oliveira and Saito 1989), failed to demonstrate antidiabetic activity (Pinheiro et al.…”
Section: Introductionmentioning
confidence: 99%