Effect of azithromycin, as an adjunct to nonsurgical periodontal treatment, on microbiological parameters and gingival crevicular fluid biomarkers in generalized aggressive periodontitis

Abstract

Adjunctive azithromycin therapy provides no additional benefit over nonsurgical periodontal treatment on clinical parameters, microbiological parameters and gingival crevicular fluid biochemical markers investigated in patients with generalized aggressive periodontitis.

Periodontal Treatment Reduces Matrix Metalloproteinase Levels in Localized Aggressive Periodontitis

“…Interestingly, MMP‐1, MMP‐8, MMP‐9, MMP‐12, and MMP‐13 have all been shown to be related to periodontal disease process, and they all showed a significant reduction over time after treatment of LAgP, as well as a positive correlation with each other 8,11,23 . Reductions of MMP‐8, MMP‐9, and MMP‐13 after periodontal treatment have also been reported previously 21 …”

“…To date, very few studies reported effects of different periodontal treatment approaches for AgP on MMP levels. Recently, Emingil et al 21 demonstrated that over a 6‐month period after periodontal treatment MMP‐8 levels in the GCF significantly decreased, along with clinical and microbiologic improvements. However, the authors used either SRP or adjunctive azithromycin therapy, and the population in the study consisted of generalized AgP patients.…”

Effects of azithromycin versus metronidazole-amoxicillin combination as an adjunct to nonsurgical periodontal therapy of generalized aggressive periodontitis

“…Emingil et al treated 32 GAP patients with nonsurgical therapy with or without AZT and found that all clinical parameters improved, and the microbiological parameters and gingival crevicular fluid matrix metalloproteinase-8 levels decreased significantly in both groups. [33] They found that AZT exerts no beneficial effect compared to nonsurgical periodontal therapy in GAP patients. In 2010, Hirsch reported three cases of chronic or aggressive periodontitis who received AZT adjunctive to nonsurgical treatment; in all cases the periodontal inflammation resolved and pocket depth decreased.…”

Clinical and Metabolic changes after the Non- surgical Periodontal Therapy in patients with Type-2 Diabetes Mellitus with Chronic periodontitis with or without the Systemic administration of Azithromycin - A Randomized Controlled Clinical Trial

“…The present study there was significant improvement in PI, GI, PD and HbA1cin both the groups but there was significant improvement in group II when compared to group I. In a randomized double-blind placebocontrolled parallel-designed studies by Emingil et al 10 Gomi et al 11 , Oteo et al 12 , Smith et al 13 …”