Effect of Au-dextran NPs as anti-tumor agent against EAC and solid tumor in mice by biochemical evaluations and histopathological investigations

Medhat, Dalia; Hussein, Jihan; El‐Naggar, Mehrez E.; Attia, Mohamed F.; Anwar, Mona; Latif, Yasmine Abdel; Booles, Hoda F.; Morsy, Safaa; Farrag, Abdel Razik H.; Khalil, Wagdy K. B.; El-Khayat, Zakaria

doi:10.1016/j.biopha.2017.05.043

Cited by 55 publications

(26 citation statements)

References 44 publications

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“…The present study revealed that; EAC induced a marked degeneration in glomeruli and some parts of the urinary tubules in kidney sections confirmed with Medhat et al and Eldaim et al reported that EAC induced cellular infiltration and necrosis in the glomeruli and renal tubules cells in cortex and medulla. In additionally, Badr et al and Salem et al indicated that EAC induced degenerated in the renal tubules and atrophy in the glomerulus as well as proteinaceous casts and leucocyte infiltration in the lumen of the renal tubules.…”

Section: Discussionsupporting

confidence: 91%

Ameliorative effects of vitamin B17 on the kidney against Ehrlich ascites carcinoma induced renal toxicity in mice

Mutar

Tousson

Hafez

et al. 2019

Environmental Toxicology

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Cancer is the major cause of death and many factors that lead to its occurrences, such as environmental pollution and pesticides and other factors. Ehrlich carcinoma development depends on many things associated with the environment, nutrition, personal habits, and family history. The present study aimed to evaluate the potential protective effects of vitamin B17 (VB17) against Ehrlich ascites carcinoma (EAC) that induced kidney toxicity in female mice. The mice were divided into five groups (first group, control group; second group, VB17 group; third group, EAC group; fourth group, pretreated EAC with VB17; fifth group, cotreated EAC with VB17). Results showed the VB17 in pretreated (G4) and cotreated (G5) groups lead to an improvement in DNA damage and cytological examination, in addition significantly (P < .05) increase in Na+, red blood cell, hemoglobin, hematocrit value, mean corpuscular hemoglobin (MCH), and MCH concentration, whereas significantly (P < .05) decrease in urea, creatinine, K+, platelets, and white blood cells while insignificant (P < .05) changes in mean corpuscular volume when compared to the EAC group. Many histopathological changes were observed in kidney sections in EAC as marked damage and degenerated, glomerular atrophy, the Malpighian corpuscles that lost their characteristic configuration. On the other hand, a moderate improvement and arrangement in the kidney histological structure in pretreated VB17 + EAC, while a mild enhancement and arrangement of the kidney structure in cotreated EAC + VB17. In addition, depletion in renal P53 and PCNA protein expression compared with the EAC group. It could be concluded that VB17 has a potential renal protective effect against EAC cells induced kidney injury.

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Section: Discussionsupporting

confidence: 91%

Ameliorative effects of vitamin B17 on the kidney against Ehrlich ascites carcinoma induced renal toxicity in mice

Mutar

Tousson

Hafez

et al. 2019

Environmental Toxicology

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“…Therefore, the hybrid materials containing silver nanoparticles are perspective for development of catalytic systems and also for use in optoelectronics and nanophotonics 3,4 . Furthermore, nanocomposite materials with silver nanoparticles are widely applied as effective antibacterial and antiviral medicines [5][6][7][8][9][10] .…”

mentioning

confidence: 99%

Effect of the type of reducing agents of silver ions in interpolyelectrolyte-metal complexes on the structure, morphology and properties of silver-containing nanocomposites

Demchenko

Riabov

Kobylinskyi

et al. 2020

Sci Rep

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The objective of this work is to study the peculiarities of structural organization, morphology, thermomechanical, electrical and antimicrobial properties of nanocomposites based on pectinpolyethyleneimine interpolyelectrolyte complexes and silver nanoparticles in dependence on the type of reducing agent being applied for chemical reduction of silver ions in the interpolyelectrolyte-metal complexes. The average size of Ag nanoparticles is shown to be increased with decreasing of the activity of reducing agent (E 0 ) and equals to 3.8 nm, 4.3 nm, and 15.8 nm, respectively, when engaging sodium borohydride (-1.24 V), hydrazine (-1.15 V) and ascorbic acid (-0.35 V). Moreover, it was found that the crystallite size of Ag nanoparticles also had the smallest value for nanocomposites obtained involving NaBH 4 as reducing agent. Ag-containing nanocomposites prepared by reduction of silver ions in interpolyelectrolyte-metal complexes while applying a range of reducing agents are characterized by different electrical properties and polymer matrix' glass transition temperature. The influence of silver nanoparticles' size incorporated in the polymer matrix on the antimicrobial activity of nanocomposites has been established. The inhibition zone diameter of Staphylococcus aureus and Escherichia coli was higher for nanocomposites obtained using sodium borohydride and hydrazine compared to nanocomposites where ascorbic acid was used as the reducing agent.

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“…International Journal of Polymer Science between EPS and metal ions to form metal nanoparticles is shown in Figure 2. In this context, it is important to mention that in most cases in which EPSs are utilized to synthesized metal nanoparticles, the EPSs act both as a reducing and stabilizing agents at the same time due to their properties and structures with many functional groups; which consequently make EPSs suitable and advantageous to produce metal nanoparticles destined to be applied in the biomedical sciences [53][54][55][56][57]. However, there are also studies in which metal nanoparticles are produced with other reducing agents or other reducing methods, where the EPSs act only as a stabilizing or capping agent [58][59][60] guluronate; carboxymethyl cellulose is a polymer of Dglucose with carboxymethyl groups bonded to the hydroxyl groups; pectin is mainly composed by galacturonic acid, linked to other components as acetic acid, D-apiose, glucorinic acid, etc.…”

Section: Eps Used In the Synthesis Of Metal Nanoparticlesmentioning

confidence: 99%

“…Dextran, is useful in the synthesis of metal nanoparticles since their hydroxyl, ketone, aldehydes, and carboxyl groups interact and allow the reduction of Ag + ions to form Ag-NPs, preventing their agglomeration as well [71,72]. At this point, it was mentioned that oxygen from dextran functional groups can donate their pair of electrons to gold ions thereby producing Au-NPs [55]. As it is well known, dextran is rich in hydroxyl groups that can interact with magnetic nanoparticles by hydrogen bonds stabilizing them [95,109].…”

Section: Potential Mechanisms That Explain the Synthesis Of Metal Nanmentioning

confidence: 99%

“…Moreover, Ag-NPs with antibacterial and antifungal properties have also been synthesized using dextran sulfate [72]. For the case of Au-NPs, these particles have been obtained using dextran as a capping and reducing agent [55]. In this study, the Au-NPs showed antitumor effects against Ehrlich ascites carcinoma and solid carcinoma transplanted in mice through tests performed to evaluate liver and kidney biochemical function, as well as oxidation stress ratio and histopathological studies.…”

mentioning

confidence: 98%

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Bacterial Exopolysaccharides as Reducing and/or Stabilizing Agents during Synthesis of Metal Nanoparticles with Biomedical Applications

Escárcega‐González

Garza-Cervantes

Vázquez-Rodríguez

et al. 2018

International Journal of Polymer Science

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Bacterial exopolysaccharides (EPSs) are biomolecules secreted in the extracellular space and have diverse biological functionalities, such as environmental protection, surface adherence, and cellular interactions. EPSs have been found to be biocompatible and eco-friendly, therefore making them suitable for applications in many areas of study and various industrial products. Recently, synthesis and stabilization of metal nanoparticles have been of interest because their usefulness for many biomedical applications, such as antimicrobials, anticancer drugs, antioxidants, drug delivery systems, chemical sensors, contrast agents, and as catalysts. In this context, bacterial EPSs have been explored as agents to aid in a greener production of a myriad of metal nanoparticles, since they have the ability to reduce metal ions to form nanoparticles and stabilize them acting as capping agents. In addition, by incorporating EPS to the metal nanoparticles, the EPS confers them biocompatibility. Thus, the present review describes the main bacterial EPS utilized in the synthesis and stabilization of metal nanoparticles, the mechanisms involved in this process, and the different applications of these nanoparticles, emphasizing in their biomedical applications.

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Effect of Au-dextran NPs as anti-tumor agent against EAC and solid tumor in mice by biochemical evaluations and histopathological investigations

Cited by 55 publications

References 44 publications

Ameliorative effects of vitamin B17 on the kidney against Ehrlich ascites carcinoma induced renal toxicity in mice

Ameliorative effects of vitamin B17 on the kidney against Ehrlich ascites carcinoma induced renal toxicity in mice

Effect of the type of reducing agents of silver ions in interpolyelectrolyte-metal complexes on the structure, morphology and properties of silver-containing nanocomposites

Bacterial Exopolysaccharides as Reducing and/or Stabilizing Agents during Synthesis of Metal Nanoparticles with Biomedical Applications

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