Effect of atorvastatin, a HMG-CoA reductase inhibitor in monosodium iodoacetate-induced osteoarthritic pain: Implication for osteoarthritis therapy

Pathak, N.N.; Balaganur, Venkanna; Lingaraju, Madhu Cholenahalli; Kant, Vinay; Kumar, Dhirendra; Kumar, Dinesh; Sharma, Anil Kumar; Tandan, Surendra K.

doi:10.1016/j.pharep.2014.12.005

Cited by 25 publications

(28 citation statements)

References 53 publications

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“…The animal model of OA induced by monosodium iodoacetate (MIA) is well‐established, presenting similarities to OA in humans . MIA injection was demonstrated to induce pain and edema, which are characteristic of the inflammatory process, as well as it causes unbalance between the production of reactive oxygen species and antioxidant activity . In addition, MIA induces important injuries in the joint cartilage .…”

Section: Introductionmentioning

confidence: 99%

Photobiomodulation therapy in knee osteoarthritis reduces oxidative stress and inflammatory cytokines in rats

Yamada

Bobinski

Martins

et al. 2019

Journal of Biophotonics

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Knee osteoarthritis (OA) is a chronic disease that causes pain and gradual degeneration of the articular cartilage. In this study, MIA‐induced OA knee model was used in rats to test the effects of the photobiomodulation therapy (PBM). We analyzed the inflammatory process (pain and cytokine levels), and its influence on the oxidative stress and antioxidant capacity. Knee OA was induced by monosodium iodoacetate (MIA) intra‐articular injection (1.5 mg/50 μL) and the rats were treated with eight sessions of PBM 3 days/week (904 nm, 6 or 18 J/cm2). For each animal, mechanical and cold hyperalgesia and spontaneous pain were evaluated; biological analyses were performed in blood serum, intra‐articular lavage, knee structures, spinal cord and brainstem. Cytokine assays were performed in knee, spinal cord and brainstem samples. The effects of the 18 J/cm2 dose of PBM were promising in reducing pain and neutrophil activity in knee samples, together with reducing oxidative stress damage in blood serum and spinal cord samples. PBM improved the antioxidant capacity in blood serum and brainstem, and decreased the knee pro‐inflammatory cytokine levels. Our study demonstrated that PBM decreased oxidative damage, inflammation and pain. Therefore, this therapy could be an important tool in the treatment of knee OA.

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Section: Introductionmentioning

confidence: 99%

Photobiomodulation therapy in knee osteoarthritis reduces oxidative stress and inflammatory cytokines in rats

Yamada

Bobinski

Martins

et al. 2019

Journal of Biophotonics

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“…However, in another study performed on rats with experimental OA, an increase in plasma SOD concomitant with depletion of plasma CAT was noted [3].…”

Section: Discussionmentioning

confidence: 99%

“…Its consequence is the constant worsening of condition, concomitant with pain as well as with joint stiffness and up to date no sufficient therapy resolving it has been found. The research on the processes involved into its pathogenesis, development and possible cures is still being continued [1,2,3,4,5,6]. The knee appears to be one of the most frequent sites affected by OA [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…In human and animal studies, the involvement of oxidative stress into both OA pathogenesis [14,21,22,23] and the effects of therapeutic agents applied in OA cases [1,2,3,24] has already been confirmed. Moreover, the beneficial effects of substances acknowledged as containing natural antioxidants, such as pomegranate juice [4] or sesame powder [15], on oxidative and lipid profile parameters in OA patients has been reported.…”

Section: Introductionmentioning

confidence: 99%

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The Oxidative Stress in Knee Osteoarthritis Patients. An Attempt of Evaluation of Possible Compensatory Effects Occurring in the Disease Development

Paździor¹,

Kiełczykowska

Kurzepa

et al. 2019

Medicina

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Background and Objective: Osteoarthritis (OA) is a disorder of the musculoskeletal system resulting in worsening of life condition. The research revealed the involvement of oxidative stress into both OA pathogenesis and the effects of therapeutic agents applied in OA cases. The activities of the most important antioxidant enzymes, namely superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and total antioxidant status (TAS), in blood of the knee OA patients were studied, with the aim of clarifying which enzymatic antioxidants are involved into osteoarthritis (OA)-related oxidative stress and whether any compensatory effects occur. The results were additionally analyzed with regard to gender. Methods: Whole blood SOD (U/mL), plasma GPx (U/L) and CAT (U/mL) activities as well as plasma TAS (mmol/L)) in knee OA patients were investigated. Sixty-seven patients (49 females and 18 males) with primary knee OA were enrolled. The control comprised 21 subjects (10 females and 11 males) free of osteoarthritis or inflammation. Results: TAS was decreased in OA subjects (4.39 ± 0.53 vs. 4.70 ± 0.60), with this effect being more significant in OA females (4.31 ± 0.51 vs. 5.02 ± 0.54). GPx was depressed in all OA patients (518 ± 176 vs. 675 ± 149). In both genders, GPx was decreased, significantly in males (482 ± 185 vs. 715 ± 105). SOD was decreased in all OA patients (109 ± 32 vs. 127 ± 42). CAT showed no difference in all OA subjects vs. control, while in OA females it was depleted (20.2 (11.6–31.6) vs. 38.5 (27.9–46.6)) and in OA men it increased (26.9 (23.3–46.5) vs. 14.0 (7.0–18.6)). Conclusions: The obtained results suggest that in men some compensatory mechanisms towards OA-related oxidative stress occurred. Based on the obtained data, the introduction of antioxidant supplements into OA therapy could be suggested with further research concerning the choice of agents.

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“…Glucosamine treated OA group: received glucosamine sulfate solution at a dose of 250 mg /kg/ day (Wen et al, 2010). Atorvastatin treated OA group: given atorvastatin solution 10 mg/kg daily (Pathak et al, 2015a). All drugs are given by oral gavage daily from 1 st day of surgery for six weeks.…”

Section: Surgical Induction Of Oamentioning

confidence: 99%

Standardized Study of Atorvastatin Possible Osteoarthritis Disease-Modifying Effect in Rats

Gaballah

Genedy

Ghayaty

et al. 2020

Preprint

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Background and purpose: Osteoarthritis (OA) is a chronic and progressive joint disorder characterized by structural damage to one or more joints. However, drugs that could cure or at least stop the progression of this disease are still given no satisfactory outcome. The purpose of this work is to study the potential OA disease-modifying effects of atorvastatin in an experimental model of osteoarthritis and the possible underlining mechanisms if any. Experimental Approach: Seventy-six adult male Sprague-Dawley rats (250-300gms) were used throughout this study. Forty rats were used to assess the effect of atorvastatin in surgically induced OA. While 36 rats were used to assess its anti-inflammatory effect in carrageenan-induced paw edema. In the model of OA; the degree of joint stiffness was assessed by measuring the angle of knee extension besides, the histopathological changes of the OA knee joints and measurement of serum Interleukin-1beta (IL-1β), Matrix metalloproteinase-13 (MMP13), and reduced glutathione (GSH) concentration were biochemically assessed. In the carrageenan-induced paw edema, the paw thickness and pain threshold were assessed in different groups. Key Results: Atorvastatin was found to produce significant improvement of joint stiffness, the histopathological changes, a significant correction in the increased MMP13 and IL1-β, and the decreased GTH in OA rats. Also, atorvastatin showed a significant improvement in both paw thickness and pain threshold. Conclusion and ImplicationsThese results present atorvastatin as OA disease-modifying drug worse clinical trials.

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Effect of atorvastatin, a HMG-CoA reductase inhibitor in monosodium iodoacetate-induced osteoarthritic pain: Implication for osteoarthritis therapy

Abstract: Our study demonstrated that atorvastatin attenuates MIA-induced osteoarthritic pain and protect cartilage degradation through inhibition of oxidative stress suggesting its importance in osteoarthritic pain management.

Cited by 25 publications

References 53 publications

Photobiomodulation therapy in knee osteoarthritis reduces oxidative stress and inflammatory cytokines in rats

Photobiomodulation therapy in knee osteoarthritis reduces oxidative stress and inflammatory cytokines in rats

The Oxidative Stress in Knee Osteoarthritis Patients. An Attempt of Evaluation of Possible Compensatory Effects Occurring in the Disease Development

Standardized Study of Atorvastatin Possible Osteoarthritis Disease-Modifying Effect in Rats

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