Effect of Artocarpus altilis fruit based-diet on liver and kidney function indices on alloxan-induced diabetic rats

Ajiboye, B.O.; Chikezie, G.S.; Aganzi, I.Y.; Ojo, Oluwafemi Adeleke; Onikanni, Sunday Amos; Afolabi, Olakunle Bamikole; Anadozie, Scholastica Onyebuchi; Sobajo, Oguntope A

doi:10.3233/mnm-160056

Cited by 6 publications

(6 citation statements)

References 25 publications

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“…Few studies have been published on the effects of extracts or essential oils from P. aduncum , M. citrifolia , and A. altilis on the hematological profiles of birds. The results obtained in the present study were like those reported in previous studies on birds ( 49 ), rats, and mice (Schuktz et al, 2017); ( 50–53 ), where similar hematological profiles were obtained on increase in the levels of P. glabratum , P. aduncum , M. citrifolia , and A. altilis extracts. However, few previous studies evaluating leaf powders of plants, such as Moringa oleifera and Azadirachta indica , demonstrated an increase in the hematological profiles of the broiler chickens ( 46 , 54 ).…”

Section: Discussionsupporting

confidence: 92%

Modulation of Gut Microbiota, and Morphometry, Blood Profiles and performance of Broiler Chickens Supplemented with Piper aduncum, Morinda citrifolia, and Artocarpus altilis leaves Ethanolic Extracts

Paredes-López,

Robles-Huaynate,

Soto-Vásquez

et al. 2024

Front. Vet. Sci.

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Bioactive plants such as P. aduncum, M. citrifolia, and A. altilis might improve intestinal health as an alternative to antibiotic growth promoters. The objective of this study was to determine the effect of the ethanolic extracts (EEs) of these plants on the intestinal health of broiler chickens. Cobb 500 chickens (n = 352) were distributed into eight treatments with four replicates and 11 chickens each. T1 received a base diet, and T2 received a base diet with 0.005% zinc bacitracin. T3, T5, and T7 were supplemented with 0.005% of P. aduncum, M. citrifolia, and A. altilis EE in the diet while T4, T6, and T8 with 0.01% of the extract. The EEs were supplemented with drinking water from 1 to 26 days of age. The following parameters were evaluated: hematological profiles at 28 days of age, blood metabolites profiles at 14, 21, and 28 days; Escherichia coli, Staphylococcus aureus, and Lactobacillus sp. abundance in the ileum mucosa and content at 21 and 28 days, and histomorphometry of the duodenum, jejunum, and ileum mucosa at 14, 21, and 28 d. Final weight (FW), weight gain (WG), feed intake (FI), and feed conversion rate (FCR) were evaluated at seven, 21, and 33 days of age. M. citrifolia and A. altilis EE at 0.01% increased blood glucose levels at 21 and 28 days of age, respectively, and P. aduncum and M. citrifolia EE at 0.01% increased triglycerides at 28 days of age; in addition, this EE did not have any effect on the AST and ALT profiles. The depths of the Lieberkühn crypts and the villi length to the crypt’s depth ratio increased with age on supplementation with 0.01% M. citrifolia and A. altilis EE at 21 days of age (p < 0.05). In addition, the depth of the crypts increased at 28 days of age (p < 0.05) in chickens supplemented with 0.01% A. altilis EE. The 0.01% M. citrifolia EE in diet decreased in the Staphylococcus aureus population in the ileal microbiota (p < 0.05). The FW and WG during the fattening and in the three stages overall increased, and the FCR decreased; however, the FI and the carcass yield did not change in the broiler chickens supplemented with 0.01% M. citrifolia EE (p < 0.05). Conclusively, the M. citrifolia EE at 0.01% of the diet improved intestinal health and thus the performance indices of the broiler chickens and did not have a detrimental effect on any of the parameters evaluated, so it is postulated as a potential alternative to AGP in poultry.

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Section: Discussionsupporting

confidence: 92%

Modulation of Gut Microbiota, and Morphometry, Blood Profiles and performance of Broiler Chickens Supplemented with Piper aduncum, Morinda citrifolia, and Artocarpus altilis leaves Ethanolic Extracts

Paredes-López,

Robles-Huaynate,

Soto-Vásquez

et al. 2024

Front. Vet. Sci.

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“…Although the study by Ajiboye et al (2016) on T. africana fruit/ seed suggested its beneficial use in the management of diabetes mellitus, our study on processed T. africana seed gave contrary results, although the duration of our study was short. Furthermore, information on the effect of consumption of processed T. africana seed on the lipid profile of humans or animals is missing in literature.…”

Section: Introductioncontrasting

confidence: 66%

Effect of ethanol extract of boiled breadfruit (Treculia Africana) seed on the oral glucose tolerance, lipid profile, and body weight of normoglycemic albino rats

Eleazu

Maduabuchi

Eleazu

2018

Food Science & Nutrition

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The effect of ethanol extracts of boiled Treculia africana seed on the oral glucose tolerance (OGTT), lipid profile, and body weight of normoglycemic albino rats was determined. Fifteen male albino rats were used and were divided into three groups of five rats each. Groups 1 and 2 received 100 and 200 mg/kg of the extract, while group 3 (control group) received 1 ml/kg of normal saline. The experiment lasted for 28 days. The body weights of the rats were determined daily. OGTT was determined at week zero (before extract administration) and at weeks 2 and 4, respectively, following extract administration. Glycemic index (GI) of the extracts was calculated from the incremental area under the OGTT curve. The total cholesterol, high‐density lipoprotein (HDL) cholesterol, low‐density lipoprotein (LDL) cholesterol, and very‐low‐density lipoprotein (VLDL) cholesterol levels in the sera of the rats were determined using standard techniques. Atherogenic index (AI) and coronary risk index (CRI) of the rats were expressed as ratios of LDL cholesterol to HDL cholesterol and total cholesterol to HDL cholesterol, respectively. Following 2 weeks of the extract administration, the blood glucose for groups 1 and 2 rats declined to values ≤100 mg/dl after oral glucose loading. GI for the standard rat feeds and the extracts at 100 and 200 mg/kg by the second week of experimentation were 100, 114, and 96.09, respectively. GI for the extract at 100 mg/kg decreased to 103.63 at the 4th week, while that for the extract at 200 mg/kg increased to 98.07. The extract at 100 mg/kg increased the LDL cholesterol, AI, and CRI of the rats, suggesting that consumption of boiled African breadfruit may expose an individual to the risk of development of cardiovascular diseases. Finally, the study suggested that consumption of T. africana seed by a nondiabetic subject may have no effect on the glucose tolerance of the individual, while it will negatively impact on the glycemic status of a diabetic subject.

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“…Oboh et al (2015) reported the glycemic index (GI) of breadfruit seed to be about 64.5, which places it as an intermediate GI crop based on the classification of GI by Brand-Miller et al (2003). On the other hand, Ajiboye et al (2016) reported the hypoglycemic action of this plant in experimentally induced diabetic rats, and the findings of this study suggest that the processing of this plant by boiling (which is the form in which it is eaten in typical diets) affects its reported hypoglycemic action. This variation between our results and those of Ajiboye and colleagues could be attributed to the fact that, while Ajiboye and colleagues worked on raw seeds, we worked on cooked seeds, and cooking has been reported to affect the nutrient constituents and the digestibility of starches in foods, which could also affect their glycemic indices (Capriles et al, 2008;Eleazu et al, 2016;Eleazu et al, 2017).…”

Section: Discussionmentioning

confidence: 57%

“…Although the hypoglycemic actions of the roots and seeds of this plant have been reported (Ajiboye et al, 2016;Olatunji et al, 2014;Oyelola et al, 2007), the effect of processing the seed (the edible part) on its hypoglycemic action has not been reported. This is especially important as the seed is eaten after being processed, and different food processing techniques could affect the starch digestibility of foods, which in essence will affect the glycemic indices of these foods.…”

Section: Introductionmentioning

confidence: 99%

Dietary intake of boiled breadfruit (Treculia africana) seeds did not improve hyperglycemia in streptozotocin induced diabetic rats: Effect on the oral glucose tolerance of normoglycemic rats

Eleazu

Ezekwibe

Egbe

et al. 2017

Acta Sci Pol Technol Aliment

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Diabetes mellitus is a global health problem that is causing problems for humans around the world and becoming increasingly prevalent at an alarming rate (Aloulou et al., 2012), including amongst the rural Nigerian population. The inability of modern treatments to control all the pathophysiological aspects of diabetes, as well as the enormous cost it imposes on the economy of the developing nations of the world, ABSTRACTBackground. Although African breadfruit (Treculia africana) is said to be useful in the dietary management of diabetes, the effect of cooking on its glycemic index has not been reported. Hence this study has investigated the effect of a dietary intake of boiled breadfruit on the serum glucose, glucose tolerance, body weights and relative organ weights of streptozotocin (STZ) induced diabetic rats. Materials and methods. Twenty albino rats were used and were divided into four groups of five rats. Groups 1 (normal control) and 2 (diabetic control) received standard rat pellets while groups 3 (diabetic-test group) and 4 (non-diabetic) rats received breadfruit. Results. The blood glucose of the normoglycemic rats fed standard rat feeds peaked at 30 min (149.75 ±11.12 mg/dl) following oral glucose loading (3 g/kg) but reduced to 85.25 ±21.05 mg/dl after another 90 min, while the blood glucose of the normoglycemic rats fed breadfruit peaked at 30 min (146.25 ±15.22 mg/dl) following oral glucose loading, but elevated (130.75 ±36.69 mg/dl) after another 90 min. There was significant elevation (P < 0.05) of the serum glucose, relative liver weight (RLW) and relative kidney weight (RKW) but a significant decrease in the body weights of the diabetic control compared with the normal control; no significant difference (P > 0.05) in the serum glucose, body weights, RLW and RKW of the test group compared with the diabetic control, and no significant differences (P > 0.05) in the serum glucose, body weights, RLW and RKW of the normal rats fed the breadfruit diet compared to the normal control. Conclusion. The study showed that the traditional method of cooking African breadfruit negatively affects its hypoglycemic property.

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Effect of Artocarpus altilis fruit based-diet on liver and kidney function indices on alloxan-induced diabetic rats

Cited by 6 publications

References 25 publications

Modulation of Gut Microbiota, and Morphometry, Blood Profiles and performance of Broiler Chickens Supplemented with Piper aduncum, Morinda citrifolia, and Artocarpus altilis leaves Ethanolic Extracts

Modulation of Gut Microbiota, and Morphometry, Blood Profiles and performance of Broiler Chickens Supplemented with Piper aduncum, Morinda citrifolia, and Artocarpus altilis leaves Ethanolic Extracts

Effect of ethanol extract of boiled breadfruit (Treculia Africana) seed on the oral glucose tolerance, lipid profile, and body weight of normoglycemic albino rats

Dietary intake of boiled breadfruit (Treculia africana) seeds did not improve hyperglycemia in streptozotocin induced diabetic rats: Effect on the oral glucose tolerance of normoglycemic rats

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