Effect of Apple (Malus domestica) Stem Cells on UVB-Induced Damage Skin with Anti-Inflammatory Properties: An In Vivo Study

Khayatan, Danial; Nilforoushzadeh, Mohammad Ali; Ashtiani, Hamid Reza Ahmadi; Hashemian, Farshad

doi:10.1155/2022/2417766

Cited by 6 publications

(7 citation statements)

References 40 publications

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“…The dressings that create moist wound healing environments include films, hydrocolloids, foams, and hydrogels. Hydrogels are not only soft, malleable, and biocompatible, but they also have other unique features (Gupta et al., 2019 , Khayatan et al., 2022 ). Recent literature studies have investigated the use of hydrogel as a wound healing scaffold.…”

Section: Introductionmentioning

confidence: 99%

The wound healing effect of collagen/adipose‐derived stem cells (ADSCs) hydrogel: In vivo study

Abbasi¹,

Tavakolizadeh²,

Hadi³

et al. 2022

Veterinary Medicine & Sci

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Background The complex wound healing process involves activating and synchronizing intracellular, intercellular, and extracellular components. Adipose tissue is attracting attention to promote wound healing. Within subcutaneous adipose tissue, stromal vascular cells and their subsets release growth factors and cytokines critical for neovascularization and wound repair. Objectives This study evaluated human placental collagen/adipose‐derived stem cells (ADSCs) hydrogel for wound healing in rats. Methods In this study, ADSCs were harvested, cultured, and mixed with placental collagen. Twelve rats were used, and their backs were excised three times each. Group one received collagen/ADSCs, group two collagen, and group three non‐filled (control) excisions. The healing processes were assessed by histological analysis, taking photographs, and calculating the percentage of wound contraction in mentioned times. Results Histopathological analysis revealed that the content of fibroblasts, follicles of the hair, and angiogenesis in group one was significantly more than in other groups. Group one had a significant result compared with the collagen and control groups. In group one, significant wound healing and wound contraction were observed with 52% and 80% wound contraction at 7 and 14 days, respectively. Conclusion Collagen/ADSCs can be considered a suitable candidate hydrogel in wound healing with a high potential for enhancing wound repairing.

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Section: Introductionmentioning

confidence: 99%

The wound healing effect of collagen/adipose‐derived stem cells (ADSCs) hydrogel: In vivo study

Abbasi¹,

Tavakolizadeh²,

Hadi³

et al. 2022

Veterinary Medicine & Sci

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“…is makes them an excellent focus for research pertaining to the prevention and treatment of infectious diseases [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesize and Characterization of Copper Nanoparticles Using Iranian Propolis Extracts

Hajizadeh

Harzandi

Babapour

et al. 2022

Advances in Materials Science and Engineering

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The propolis produced by bees is used by them to protect their hives. The cavity inside the hive’s walls is filled in during cold days to reduce entry points and mummify any intruders to ensure their survival. A current focus in nanotechnology and nanoscience is the green biosynthesis of nanoparticles (NPs) using biomaterials. Research on green methods for making metal oxide NPs is gaining momentum to safeguard the environment from the potential dangers associated with toxic chemicals. This study aimed to synthesize copper NPs (CuNPs) via propolis extraction, a novel application of nanoscience. The study was conducted under a range of pH, time conditions, and concentration ratios, and its properties were characterized by UV-Vis absorption spectra, XRD, and FTIR. An FTIR analysis revealed that compounds found in propolis extract could have an effect on the surface modification of the synthesized NPs. The propolis (Khalkhal) extract spectrum exhibited a sharp peak at 3422 cm−1, caused by free hydroxyl groups and their intra/intermolecular hydrogen bonds. There were sharp peaks at 2925, 1637, and 1515 to 1076 cm−1 associated with the C = O and C = C aromatic stretching frequencies. According to UV-Vis spectrophotometry investigation, CuO NPs exhibit a characteristic peak at 385 nm, showing significant surface plasmon resonance (SPR) with propolis (Khalkhal) extract. Furthermore, specific wavelengths of CuO NPs demonstrate peaks at 243, 292, and 350 nm for propolis (Gilan) extract. The green synthesis of CuNPs from Gilan and Khalkhal propolis can be an appropriate candidate for clinical applications such as drug delivery systems, drug formulation, and biomedical applications.

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“…The search for herbal cures or plants has become increasingly important as the number of natural therapies increases [ 12 ]. Natural components have a role in medicine development [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Development of Nanoemulsions for Wound Dressings Containing Cassia alata L. Leaf Extraction

Sangkaew

Wanmasae

Bunluepeuch

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Natural polymer-based hydrogel films possess considerable potential for use in biomedical applications and are excellent for wound healing. The purpose of this research was to use ionic crosslinking to improve the mechanical characteristics, absorption of fluid in the wound, and drug release behavior of Cassia alata L. (CA) extract loaded niosomes (CANs) that were incorporated in an alginate-pectin film (A/P). Then, chemically crosslinked A/P hydrogels were obtained by immersing them in different concentrations of calcium chloride (CaCl2) (0.5–1% w/v) for 15–120 s. The degree of crosslinking was controlled by both contact time and CaCl2 concentration. The optimal crosslinking conditions were 1% CaCl2 for 15 seconds. In this study, the following features of the hydrogel films were investigated: physical properties, morphological characteristics, drug loading, in vitro drug release, antibacterial activity, wound healing activity, cytocompatibility profiles, and hemocompatibility. The crosslinked hydrogel films maintained their physical integrity during use, with the 1% film attaining the best results in the shortest period (15 sec). Then, in vitro drug release from the films was examined. Crosslinking was observed to prolong the release of the CA extract from the hydrogel film. Finally, a cell viability experiment was conducted to evaluate the cytotoxicity profile. The A/P composite film exhibited excellent wound dressing qualities and good mechanical properties in preformulation testing. The in vitro drug release profile indicated that the A/P created a regulated drug release profile, and the cell viability experiment revealed that the film was nontoxic and hemocompatible. A/P composite films can be produced using CAN extract as a possible wound dressing. However, further studies in animals and humans are required to determine both safety and effectiveness.

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Effect of Apple (Malus domestica) Stem Cells on UVB-Induced Damage Skin with Anti-Inflammatory Properties: An In Vivo Study

Cited by 6 publications

References 40 publications

The wound healing effect of collagen/adipose‐derived stem cells (ADSCs) hydrogel: In vivo study

The wound healing effect of collagen/adipose‐derived stem cells (ADSCs) hydrogel: In vivo study

Green Synthesize and Characterization of Copper Nanoparticles Using Iranian Propolis Extracts

Development of Nanoemulsions for Wound Dressings Containing Cassia alata L. Leaf Extraction

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