Effect of Anthocyanin-Rich Tart Cherry Extract on Inflammatory Mediators and Adipokines Involved in Type 2 Diabetes in a High Fat Diet Induced Obesity Mouse Model

Nemes, Andrea; Homoki, Judit; Kiss, Rita; Hegedűs, Csaba; Kovács, Dóra; Peitl, Barna; Gál, Ferenc; Stündl, László; Szilvássy, Zoltán; Remenyik, Judit

doi:10.3390/nu11091966

Cited by 50 publications

(47 citation statements)

References 77 publications

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“…The purified cyanidin 3-glucoside used in the diet of the rats has found to stimulate adipocytokine (leptin and adiponectin) secretion in the adipose tissue (Nemes et al, 2019). But, there are also the findings in which the different correlation between leptin and adiponectin was found.…”

Section: Leptin Activitymentioning

confidence: 99%

Obesity-associated Pathways of Anthocyanins

et al. 2021

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Anthocyanins have a great potential for human health, as a subgroup of phenolic compounds. Interactions of anthocyanin involved in digestion and thus in obesity consist of inhibition of pancreatic lipase, regulation of lipolysis and lipogenesis, activation of an activated protein kinase enzyme, controlling of digestion hormones (leptin, insulin, ghrelin, cholecystokinin, GIP, GLP-1). Anthocyanins are the compounds that can control metabolic syndrome and obesity by ameliorating lipid metabolism, increasing energy expenditure, suppressing food intake and inhibiting lipid absorption. In addition, the interactions with other compounds during the processing and/or in the intestinal canal can change their absorption capability and bioavailability. Activation of mitogen-activated protein kinase and cyclooxygenase (COX) enzymes, inflammatory cytokines signaling, free-radical scavenging activity are among the primary functions of anthocyanins playing role in the basic metabolic pathways. Anthocyanins also interact with gut microbiota that plays a role in many metabolic pathways. In the review, the effects of anthocyanins on the obesity-associated mechanisms in the metabolism are considered and summarized under the light of recent researches.

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Section: Leptin Activitymentioning

confidence: 99%

Obesity-associated Pathways of Anthocyanins

et al. 2021

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“…Nemes et al [ 72 ] found that the intervention of anthocyanin-rich tart cherry extract effectively improved the antioxidant capacity of high-fat-diet-fed (45% energy from fat in diet and 5% sucrose in water) mice, but failed to retain body mass and glucose tolerance. Levels of IL-6 and leptin were reduced in the treatment group compared to control.…”

Section: Anthocyanins and Obesitymentioning

confidence: 99%

The Influence of Supplementation of Anthocyanins on Obesity-Associated Comorbidities: A Concise Review

Sivamaruthi

Kesika

Chaiyasut

2020

Foods

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Anthocyanins are water-soluble plant pigments, and based on their chemical structure (nature, position, and the number of sugar moieties attached; the number of hydroxyl groups; acylation of sugars with acids) about 635 different anthocyanins have been identified and reported from plants. Cyanidin, peonidin, pelargonidin, petunidin, and malvidin are the commonly found anthocyanidins (aglycon forms of anthocyanins) in edible plants out of almost 25 anthocyanidins that are identified (based on the position of methoxyl and hydroxyl groups in the rings) in nature. Anthocyanins are known for numerous health benefits including anti-diabetes, anti-obesity, anti-inflammatory bowel disease, anti-cancer, etc. Obesity can be defined as excessive or abnormal adipose tissue and body mass, which increases the risk of developing chronic diseases such as diabetes, cardiovascular diseases, cancers, etc. The manuscript summarizes the recent updates in the effects of anthocyanins supplementation on the health status of obese subjects, and briefly the results of in vitro and in vivo studies. Several studies confirmed that the consumption of anthocyanins-rich food improved obesity-associated dysbiosis in gut microbiota and inflammation in adipose tissue. Anthocyanin consumption prevents obesity in healthy subjects, and aids in maintaining or reducing the body weight of obese subjects, also improving the metabolism and energy balance. Though preclinical studies proved the beneficial effects of anthocyanins such as the fact that daily intake of anthocyanin rich fruits and vegetables might aid weight maintenance in every healthy individual, Juҫara pulp might control the inflammatory status of obesity, Queen garnet plum juice reduced the blood pressure and risk factors associated with metabolic disorders, and highbush organic blueberries improved the metabolism of obese individuals, we don’t have an established treatment procedure to prevent or manage the over-weight condition and its comorbidities. Thus, further studies on the optimum dose, duration, and mode of supplementation of anthocyanins are required to develop an anthocyanins-based clinical procedure.

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“…Flame Ionization Detector (FID) was used for identification of oligosaccharides. Anthocyanins supplement (TS6) was determined as Nemes et al [163] Anthocyanins were extracted from Hungarian sour cherry. Cherries were deseeded and homogenised, then methanol:water:acetic acid solution in 25:24:1 ratio was utilized to extract anthocyanins.…”

Section: Determination Of Natural Feed Additivesmentioning

confidence: 99%

Nutraceuticals Induced Structural Changes in Broiler Gastrointestinal Tract Microbiota

Tolnai¹,

Fauszt²,

Fidler³

et al. 2020

Preprint

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Background The effects of nutraceuticals on the modulation of the intestinal microbiota are receiving increased attention however there are scarce number of studies investigating their effects in broiler meat production. The aim of this study was to implement feeding strategies and carry out a comprehensive trial on the interplay between carotenoids, anthocyanins, fructo-oligosaccharides, probiotics and gastrointestinal tract microbiota. Our feeding program was applied on an intensive production system with 1080 broiler Ross 308 flock.Results We observed that nutraceuticals and synbiotics did not affect growth performance remarkably nevertheless, positive correlation was found between body weight and the beneficious Bacteroidales, Corynebacteriales and Pseudomonadales. Nutraceuticals were shown to boost broiler intestinal diversity and differentially enriched Lactobacillus, Enterococcus, Streptococcus and Escherichia-Shigella in core microbiome during the different stages of broiler rearing. Furthermore, diet supplemented with different nutraceuticals was shown to increase the number of unique beneficial bacteria (Faecalibacterium, Akkermansia).Conclusion We concluded that nutraceutical-based feeding strategies can offer a promising, green approach for intensive poultry rearing by improving the health and production of livestock. We believe that the conversion of food industrial waste would result more sustainable bioactive component rich forages which invention could be implemented by other commercial antibiotic-free animal production system providing safe and quality meat.

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Effect of Anthocyanin-Rich Tart Cherry Extract on Inflammatory Mediators and Adipokines Involved in Type 2 Diabetes in a High Fat Diet Induced Obesity Mouse Model

Cited by 50 publications

References 77 publications

Obesity-associated Pathways of Anthocyanins

Obesity-associated Pathways of Anthocyanins

The Influence of Supplementation of Anthocyanins on Obesity-Associated Comorbidities: A Concise Review

Nutraceuticals Induced Structural Changes in Broiler Gastrointestinal Tract Microbiota

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