Effect of angiotensin II pathway inhibitors on post-surgical adhesion band formation: a potential repurposing of old drugs

Nazari, Seyedeh Elnaz; Naimi, Hamideh; Sayyed-Hosseinian, Sayyed-Hadi; Vahedi, Ehsan; Daghiani, Maryam; Asgharzadeh, Fereshteh; Askarnia-Faal, Mohammad-Mostafa; Avan, Amir; Khazaei, Majid; Hassanian, Seyed Mahdi

doi:10.1016/j.injury.2022.08.046

Cited by 4 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, as Ang II inhibitors, telmisartan and enalapril were regarded as effective candidates for reversing oxidative stress markers including malonyl dialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and thiol. Significant alterations of collagen deposition, biomechanical properties and adhesion formation were observed through inhibiting Ang II pathway [72] . Furthermore, vitamin is an indispensable nutrient for maintaining health and also serves as natural antioxidant.…”

Section: Therapeutic Intervention Of Pamentioning

confidence: 99%

Peritendinous adhesion: Therapeutic targets and progress of drug therapy

Wang,

Sha,

Zhao

et al. 2024

Computational and Structural Biotechnology Journal

View full text Add to dashboard Cite

Section: Therapeutic Intervention Of Pamentioning

confidence: 99%

Peritendinous adhesion: Therapeutic targets and progress of drug therapy

Wang,

Sha,

Zhao

et al. 2024

Computational and Structural Biotechnology Journal

View full text Add to dashboard Cite

“…In addition to the above applications, there are also papers regarding the use of ARBs in the treatment of cancer, 14 stroke, 15 migraines and Marfan's syndrome, 16,17 the healing of diabetic foot ulcers, 82 as well as supporting regeneration after tendon injury. 83 Most of these diseases are related to malfunction of the renin-angiotensin system; the introduction of ARBs allows regulation of this system and reduction of symptoms of the disease. Typically, the proposed treatment of the above diseases is based on a combination therapy, of which ARBs are an important component (Figure 4).…”

Section: Arbs In Alzheimer's Diseasementioning

confidence: 99%

New Perspectives for Antihypertensive Sartans as Components of Co-crystals and Co-amorphous Solids with Improved Properties and Multipurpose Activity

Turek,

Różycka-Sokołowska,

Owsianik

et al. 2023

Mol. Pharmaceutics

View full text Add to dashboard Cite

“…For the H&E sections, renal cortical vacuolization, proximal tubule simplification, renal cortical vacuolization, and peritubular/proximal tubule leukocyte infiltration were evaluated and scored as follows: normal = 0, <25% injury = 1, >25-50% injury = 2, and 50-75% injury = 3, >100% injury = 4. The injury scoring in H&E stain was evaluated by an experienced pathologist blindly; Masson's trichrome staining was used to measure the inflammatorycell accumulation and collagen deposition in the kidney-tissue sections [47].…”

Section: Tissue-injury Scorementioning

confidence: 99%

ω-3 Polyunsaturated Fatty Acids Improve the Blood–Brain-Barrier Integrity in Contrast-Induced Blood–Brain-Barrier Injury in Uremic Mice

Shin

Park

Choi

et al. 2023

IJMS

View full text Add to dashboard Cite

In patients with chronic kidney disease, the need for examinations using contrast media (CM) increases because of underlying diseases. Although contrast agents can affect brain cells, the blood–brain barrier (BBB) protects against brain-cell damage in vivo. However, uremia can disrupt the BBB, increasing the possibility of contrast-agent-induced brain-cell damage in patients with chronic kidney disease (CKD). ω-3 polyunsaturated fatty acids (PUFAs) have shown protective effects on various neurological disorders, including uremic brain injury. This study examined whether ω-3 PUFAs attenuate damage to the BBB caused by uremia and contrast agents in a uremic mouse model and evaluated its associated mechanisms. C57BL/6 mice (eight weeks old, male) and fat-1 mice (b6 background/eight weeks old, male) were divided into groups according to uremic induction, CM, and ω-3 PUFA administration. Uremia was induced via 24 h ischemia–reperfusion (IR) renal injury. One day after CM treatment, the brain tissue, kidney tissue, and blood were collected. The expression levels of glial fibrillary acidic protein (GFAP), claudin 5, CD31, laminin α4, and laminin α5 increased in ω-3 PUFA + CM-treated uremic mice and the brain of fat-1 + CM-treated uremic mice compared with those in the brains of CM-treated uremic mice. The pro-apoptotic protein expression decreased, whereas the anti-apoptotic proteins increased in ω-3 PUFA + CM-treated uremic mice and fat-1 + CM-treated uremic mice compared with CM-treated uremic mice. In addition, the brain-expression levels of p-JNK, p-P53, and p-P38 decreased in the ω-3 PUFA + CM-treated uremic mice and fat-1 + CM-treated uremic mice compared with those in wild-type uremic mice. Our results confirm that uremic toxin and CM damage the BBB and cause brain-cell death. ω-3 PUFAs play a role in BBB protection caused by CM in uremic mice.

show abstract

Effect of angiotensin II pathway inhibitors on post-surgical adhesion band formation: a potential repurposing of old drugs

Cited by 4 publications

References 39 publications

Peritendinous adhesion: Therapeutic targets and progress of drug therapy

Peritendinous adhesion: Therapeutic targets and progress of drug therapy

New Perspectives for Antihypertensive Sartans as Components of Co-crystals and Co-amorphous Solids with Improved Properties and Multipurpose Activity

ω-3 Polyunsaturated Fatty Acids Improve the Blood–Brain-Barrier Integrity in Contrast-Induced Blood–Brain-Barrier Injury in Uremic Mice

Contact Info

Product

Resources

About