Effect of an Internet-based, personalized nutrition randomized trial on dietary changes associated with the Mediterranean diet: the Food4Me Study

Livingstone, Katherine M.; Celis-Morales, Carlos; Navas-Carretero, Santiago; San-Cristóbal, Rodrigo; Macready, Anna L.; Fallaize, Rosalind; Forster, Hannah; Woolhead, Clara; O'Donovan, C.B.; Marsaux, Cyril F. M.; Kolossa, Silvia; Tsirigoti, Lydia; Lambrinou, Christina P.; Moschonis, George; Godlewska, Magdalena; Surwiłło, Agnieszka; Drevon, Christian A.; Μanios, Yannis; Traczyk, Iwona; Gibney, Eileen R.; Brennan, Lorraine; Walsh, Marianne C.; Lovegrove, Julie A.; Saris, Wim H. M.; Daniel, Hannelore; Gibney, Mike; Martínéz, J. Alfredo; Mathers, John C.

doi:10.3945/ajcn.115.129049

Cited by 77 publications

(91 citation statements)

References 38 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, a reduced set of standard clinical parameters allowing the identification of distinct metabolic subgroups may be useful in practice, for example, for effective targeted strategies for disease prevention at the metabotype subgroup level. [ 1,7,16–19 ] In previous work in an Irish cross‐sectional study in adults ( n = 875), named Irish National Adult Nutrition Survey (NANS), O'Donovan et al. [ 20 ] identified three metabolically distinct subgroups of individuals using k ‐means cluster analysis based on the four clinical standard serum parameters triacylglycerol (TAG), total cholesterol (TC), HDL cholesterol, and glucose.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Metabotype Concept Identified in an Irish Population in the German KORA Cohort Study

Riedl

Hillesheim

Wawro

et al. 2020

Molecular Nutrition Food Res

Self Cite

View full text Add to dashboard Cite

Scope: Previous work identified three metabolically homogeneous subgroups of individuals ("metabotypes") using k-means cluster analysis based on fasting serum levels of triacylglycerol, total cholesterol, HDL cholesterol, and glucose. The aim is to reproduce these findings and describe metabotype groups by dietary habits and by incident disease occurrence. Methods and results: 1744 participants from the KORA F4 study and 2221 participants from the KORA FF4 study are assigned to the three metabotype clusters previously identified by minimizing the Euclidean distances. In both KORA studies, the assignment of participants results in three metabolically distinct clusters, with cluster 3 representing the group of participants with the most unfavorable metabolic characteristics. Individuals of cluster 3 are further characterized by the highest incident disease occurrence during follow-up; they also reveal the most unfavorable diet with significantly lowest intakes of vegetables, dairy products, and fibers, and highest intakes of total, red, and processed meat. Conclusion: The three metabotypes originally identified in an Irish population are successfully reproduced. In addition to this validation approach, the observed differences in disease incidence across metabotypes represent an important new finding that strongly supports the metabotyping approach as a tool for risk stratification.

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of the Metabotype Concept Identified in an Irish Population in the German KORA Cohort Study

Riedl

Hillesheim

Wawro

et al. 2020

Molecular Nutrition Food Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…For example, it was shown that gene-based personalized nutrition targeting the apolipoprotein E ( APOE ) gene was more effective in reducing saturated fat intake compared with standard dietary advice [34]. Also, greater Mediterranean diet scores were reported among participants who received gene-based personalized nutrition targeting specific variants in five nutrient-responsive genes compared with those who received dietary advice on the basis of current diet plus phenotype [35]. Furthermore, it was reported that disclosure of genetic information regarding angiotensin I converting enzyme ( ACE ) genotype for personalized nutrition resulted in greater changes in sodium intake compared to general population-based dietary advice [36].…”

Section: Genetic Background and Nutritional Prescriptionsmentioning

confidence: 99%

Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity

Ramos-López

Milagro

Allayee³

et al. 2017

Lifestyle Genomics

Self Cite

137

View full text Add to dashboard Cite

Chronic diseases, including obesity, are major causes of morbidity and mortality in most countries. The adverse impacts of obesity and associated comorbidities on health remain a major concern due to the lack of effective interventions for prevention and management. Precision nutrition is an emerging therapeutic approach that takes into account an individual's genetic and epigenetic information, as well as age, gender, or particular physiopathological status. Advances in genomic sciences are contributing to a better understanding of the role of genetic variants and epigenetic signatures as well as gene expression patterns in the development of diverse chronic conditions, and how they may modify therapeutic responses. This knowledge has led to the search for genetic and epigenetic biomarkers to predict the risk of developing chronic diseases and personalizing their prevention and treatment. Additionally, original nutritional interventions based on nutrients and bioactive dietary compounds that can modify epigenetic marks and gene expression have been implemented. Although caution must be exercised, these scientific insights are paving the way for the design of innovative strategies for the control of chronic diseases accompanying obesity. This document provides a number of examples of the huge potential of understanding nutrigenetic, nutrigenomic, and nutriepigenetic roles in precision nutrition.

show abstract

“…Increased understanding of gene-nutrient interactions may facilitate health and disease prevention (Casas et al, 2016; Corella et al., 2016;Celis-Morales et al, 2016). A growing market offers genetic tests "direct-toconsumer" as well as via healthcare professionals.…”

Section: Introductionmentioning

confidence: 99%

“…A growing market offers genetic tests "direct-toconsumer" as well as via healthcare professionals. The Food4me project has illustrated how personalized nutrition can be delivered online to the public (Celis-Morales et al, 2016). Tests can deliver information linking diet to health, lifestyle, weight or improved fitness (Covolo et al, 2015; Bloss et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Perceptions and experiences of early-adopting registered dietitians in integrating nutrigenomics into practice

Abrahams

Frewer

Bryant

et al. 2018

BFJ

View full text Add to dashboard Cite

Design/Method/Approach -Registered Dietitians (RD´s) (N=14) were recruited from the UK, Canada, South-Africa, Australia, Mexico and Israel. Six qualitative interviews and two focus groups were conducted online using a conference calling platform. Data were recorded, transcribed and thematically analysed.Findings -Early adopters of Nutrigenomics (NGx) were experienced, self-efficacious RD's who actively sought knowledge of NGx through communication with one another and the broader scientific community. They considered NGx an extension of current practice and believed RD's had the skills to deliver it. Perceived barriers to widening the application of NGx were linked to skepticism among the wider dietetics community.Proliferation of unregulated websites offering tests and diets was considered 'pseudoscience' and detrimental to dietetics fully embracing NGx. Lack of a sustainable public health model for the delivery of NGx was also perceived to hinder progress.Results are discussed with reference to 'diffusion of innovation theory'.Originality/Value -The views of RD's who practice NGx have not been previously studied. These data highlight requirements for future dietetic training provision and more inclusive service delivery models. Regulation of NGx services and formal recognition by professional bodies is needed to address the research/practice translation gap. Further research is required to enquire as to the views of the wider dietetics profession. Paper Type Research article. IntroductionNutritional genomics (NGx) is an emerging field focused on interactions between food, nutrition and genes (Ferguson et al., 2016). Increased understanding of gene-nutrient interactions may facilitate health and disease prevention (Casas et al., 2016; Corella et al., 2016;Celis-Morales et al., 2016). A growing market offers genetic tests "direct-toconsumer" as well as via healthcare professionals. The Food4me project has illustrated how personalized nutrition can be delivered online to the public (Celis-Morales et al., 2016). Tests can deliver information linking diet to health, lifestyle, weight or improved fitness (Covolo et al., 2015; Bloss et al., 2011). Omics technologies (metabolomics, lipidomics and transcriptomics) enable highly personalized and targeted approaches to dietary health promotion (Sun and Hu, 2016) which have already been shown effective for outcomes related to cardiovascular disease (Fitó et al., 2016). Consumer interest is high and demand for trained practitioners expected to increase (Berezowska et al., 2015). Registered Dietitians (RD´s) will be key professionals for translating the science of nutrigenomics into practice (Berezowska et al., 2015; Abrahams et al., 2017;Stewart-Knox et al., 2016; Fallaize et al., 2015;Stewart-Knox et al., 2013). TheAcademy of Nutrition and Dietetics (A.N.D), however, do not consider the field ready for routine practice (Camp and Trujillo, 2014), so that application of nutritional genomics has tended to be low amongst the dietetics profession (Collins et al., 2013; W...

show abstract

Effect of an Internet-based, personalized nutrition randomized trial on dietary changes associated with the Mediterranean diet: the Food4Me Study

Cited by 77 publications

References 38 publications

Evaluation of the Metabotype Concept Identified in an Irish Population in the German KORA Cohort Study

Evaluation of the Metabotype Concept Identified in an Irish Population in the German KORA Cohort Study

Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity

Perceptions and experiences of early-adopting registered dietitians in integrating nutrigenomics into practice

Contact Info

Product

Resources

About