Effect of  -Aminocaproic Acid on Postvitrectomy Hemorrhage

Effect of tranexamic acid on postvitrectomy haemorrhage in diabetic patients

“…Schachat et al [3] reported vitreous haemorrhage in 75% of eyes immediately after surgery, and 29% had recurrent haemorrhage after the initial postoperative period. Recently epsilon-aminocaproic acid has been reported to reduce postvitrectomy haemorrhage in the early postoperative period [1]. We performed a prospective controlled study of the effect of another synthetic antifibrinolytic agent, tranexamic acid, on postoperative vitreous haemorrhage after vitrectomy for diabetic retinopathy.…”

“…In a prospective study de Bustros and coworkers [1] found a significant decrease in the amount of postoperative vitreous haemorrhage in the ira- mediate postoperative period in patients treated with epsilon-aminocaproic acid, but there was no difference in the amount of over-all haemorrhages between the treated and untreated groups. In the present study we used tranexamic acid, another synthetic amino acid which, like epsilon-aminocaproic acid, should inhibit lysis of the clot by preventing the conversion of plasminogen to plasrain, but it is 10 times more potent per gram than epsilon-aminocaproic acid.…”

Effect of tranexamic acid on postvitrectomy haemorrhage in diabetic patients

“…Schachat et al [3] reported vitreous haemorrhage in 75% of eyes immediately after surgery, and 29% had recurrent haemorrhage after the initial postoperative period. Recently epsilon-aminocaproic acid has been reported to reduce postvitrectomy haemorrhage in the early postoperative period [1]. We performed a prospective controlled study of the effect of another synthetic antifibrinolytic agent, tranexamic acid, on postoperative vitreous haemorrhage after vitrectomy for diabetic retinopathy.…”

“…In a prospective study de Bustros and coworkers [1] found a significant decrease in the amount of postoperative vitreous haemorrhage in the ira- mediate postoperative period in patients treated with epsilon-aminocaproic acid, but there was no difference in the amount of over-all haemorrhages between the treated and untreated groups. In the present study we used tranexamic acid, another synthetic amino acid which, like epsilon-aminocaproic acid, should inhibit lysis of the clot by preventing the conversion of plasminogen to plasrain, but it is 10 times more potent per gram than epsilon-aminocaproic acid.…”

Intravitreal injection of bevacizumab and triamcinolone acetonide at the end of vitrectomy for diabetic vitreous hemorrhage: a comparative study

“…Late vitreous hemorrhage may be caused by anterior hyaloidal fibrovascular proliferation or neovascularization originating from the sclerotomy sites [4]. Systemic administration of antifibrinolytic medications and intravitreal infusion of short-acting gas are used to reduce the incidence, but the results are unsatisfactory [5,6].…”

A disposable system for rapid purification of autologous plasmin as an adjunct to vitrectomy — performance and safety profile

“…Intravitreal applications of ε-aminocaproic acid have not been reported, but systemic and topical application have been investigated for control of postoperative intravitreal hemorrhage. While no success was reached in that matter, there was also no mention of ocular toxicity [47][48][49][50].…”

Effect of tranexamic acid on postvitrectomy haemorrhage in diabetic patients

“…Schachat et al [3] reported vitreous haemorrhage in 75% of eyes immediately after surgery, and 29% had recurrent haemorrhage after the initial postoperative period. Recently epsilon-aminocaproic acid has been reported to reduce postvitrectomy haemorrhage in the early postoperative period [1]. We performed a prospective controlled study of the effect of another synthetic antifibrinolytic agent, tranexamic acid, on postoperative vitreous haemorrhage after vitrectomy for diabetic retinopathy.…”

“…In a prospective study de Bustros and coworkers [1] found a significant decrease in the amount of postoperative vitreous haemorrhage in the ira- mediate postoperative period in patients treated with epsilon-aminocaproic acid, but there was no difference in the amount of over-all haemorrhages between the treated and untreated groups. In the present study we used tranexamic acid, another synthetic amino acid which, like epsilon-aminocaproic acid, should inhibit lysis of the clot by preventing the conversion of plasminogen to plasrain, but it is 10 times more potent per gram than epsilon-aminocaproic acid.…”

Intravitreal injection of bevacizumab and triamcinolone acetonide at the end of vitrectomy for diabetic vitreous hemorrhage: a comparative study

“…Late vitreous hemorrhage may be caused by anterior hyaloidal fibrovascular proliferation or neovascularization originating from the sclerotomy sites [4]. Systemic administration of antifibrinolytic medications and intravitreal infusion of short-acting gas are used to reduce the incidence, but the results are unsatisfactory [5,6].…”

A disposable system for rapid purification of autologous plasmin as an adjunct to vitrectomy — performance and safety profile

“…Intravitreal applications of ε-aminocaproic acid have not been reported, but systemic and topical application have been investigated for control of postoperative intravitreal hemorrhage. While no success was reached in that matter, there was also no mention of ocular toxicity [47][48][49][50].…”

Effect of tranexamic acid on postvitrectomy haemorrhage in diabetic patients

“…Schachat et al [3] reported vitreous haemorrhage in 75% of eyes immediately after surgery, and 29% had recurrent haemorrhage after the initial postoperative period. Recently epsilon-aminocaproic acid has been reported to reduce postvitrectomy haemorrhage in the early postoperative period [1]. We performed a prospective controlled study of the effect of another synthetic antifibrinolytic agent, tranexamic acid, on postoperative vitreous haemorrhage after vitrectomy for diabetic retinopathy.…”

“…In a prospective study de Bustros and coworkers [1] found a significant decrease in the amount of postoperative vitreous haemorrhage in the ira- mediate postoperative period in patients treated with epsilon-aminocaproic acid, but there was no difference in the amount of over-all haemorrhages between the treated and untreated groups. In the present study we used tranexamic acid, another synthetic amino acid which, like epsilon-aminocaproic acid, should inhibit lysis of the clot by preventing the conversion of plasminogen to plasrain, but it is 10 times more potent per gram than epsilon-aminocaproic acid.…”

Intravitreal injection of bevacizumab and triamcinolone acetonide at the end of vitrectomy for diabetic vitreous hemorrhage: a comparative study

“…Late vitreous hemorrhage may be caused by anterior hyaloidal fibrovascular proliferation or neovascularization originating from the sclerotomy sites [4]. Systemic administration of antifibrinolytic medications and intravitreal infusion of short-acting gas are used to reduce the incidence, but the results are unsatisfactory [5,6].…”

A disposable system for rapid purification of autologous plasmin as an adjunct to vitrectomy — performance and safety profile

“…Intravitreal applications of ε-aminocaproic acid have not been reported, but systemic and topical application have been investigated for control of postoperative intravitreal hemorrhage. While no success was reached in that matter, there was also no mention of ocular toxicity [47][48][49][50].…”