Effect of Aluminum on Hematopoiesis after Intraperitoneal Exposure in Rats

Chmielnicka, Jadwiga; Nasiadek, Marzenna; E, Lewandowska-Zyndul; Pińkowski, Roman

doi:10.1006/eesa.1996.0026

Cited by 26 publications

(15 citation statements)

References 2 publications

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“…The Fe content in the healthy body is maintained in a tight balance, and the serum Fe levels can be used as a marker for whole body Fe levels. Statistically significant decreases in serum Fe levels in rats were observed by intraperitoneal injections of aqueous Al (OH) 3 (4 mg Al·kg -1 body weight) solution for 3 weeks [16]. By contrast, decreased serum Fe concentrations were not observed in foundry workers exposed to Al 2 O 3 dust (>1 mg Al/m 3 air) [17].…”

Section: Discussionmentioning

confidence: 96%

Effects of Subchronic Aluminum Exposure on Serum Concentrations of Iron and Iron-Associated Proteins in Rats

Zhang

et al. 2010

Biol Trace Elem Res

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The purpose of the study was to investigate the effect of subchronic aluminum (Al) exposure on iron (Fe) homeostasis in rats. One hundred Wistar rats were divided into two groups. Experimental rats were given drinking water containing aluminum chloride (AlCl(3), 430 mg Al(3+)·L(-1)), while control rats were given distilled water for up to 150 days. Ten rats were sacrificed in each group every 30 days. Mean corpuscular hemoglobin (MCH), and serum levels of Al, Fe, transferrin (TF), total iron binding capacity (TIBC), and soluble transferrin receptor (sTfR) were measured. Al-treated rats showed significantly decreased bodyweight and increased Al and Al/Fe levels during the experimental period. Fe levels and MCH were higher on day 150 in the experimental group than in the control group. TF content and TIBC were higher, whereas erythrocyte counts and sTfR content were lower in the experimental group than in the control group from days 90 and 60, respectively. Longer duration of Al administration increased the serum levels of Al, TF, Al/Fe, and TIBC and decreased sTfR. MCH and Fe levels decreased first, and then increased. The results indicate that chronic exposure to Al disturbed Fe homeostasis.

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Section: Discussionmentioning

confidence: 96%

Effects of Subchronic Aluminum Exposure on Serum Concentrations of Iron and Iron-Associated Proteins in Rats

Zhang

et al. 2010

Biol Trace Elem Res

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“…This also occurs, in cases of tin, lead, arsenic, and aluminum intoxication, probably because of the reduction of Fe> by these metals. Toxic metals and also aluminum interfere with the biosynthesis of heme at several enzymatic steps with the use of iron (Woods et al, 1979(Woods et al, , 1984Buchet et al, 1987;Maines, 1988;Fulton and Je!ery, 1994;Chmielnicka et al, 1994aChmielnicka et al, , 1996Hernandez-Zarala et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Analysis of Urinary Porphyrins in Rats Exposed to Aluminum and Iron

Nasiadek

Chmielnicka

Subdys

2001

Ecotoxicology and Environmental Safety

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“…The existing data concerning changes in Fe tissue concentrations induced by Al di!er and to a large extent depend not only on the type of Al compounds (Valdivia et al, 1978;Greger et al, 1986), but also on the route of administration Chmielnicka et al, 1996). In the present experiment no changes were detected in Fe liver concentration following the administration of aluminum chloride (Table 1), which may result from the fact that Al is accumulated in spleen rather than in liver Brown and Schwarz, 1992).…”

Section: Discussionmentioning

confidence: 99%

“…Aluminum a!ects various stages of heme biosynthesis by changing the activity of some enzymes (Meredith et al, 1977(Meredith et al, , 1979Bia et al, 1989;Rosenlof et al, 1990;Chmielnicka et al, 1994bChmielnicka et al, , 1996, globin synthesis (McGonigle and Parsons, 1985), and iron metabolism (DruK eke et al, 1986;DruK eke, 1993;Allain et al, 1988).…”

Section: Introductionmentioning

confidence: 99%