Effect of Aloe vera on the Expression of Nerve Factors, p75 and TrkA Receptors in the Hippocampus of Diabetic Rats

Mahabady, Mahmood Khaksary; Tapebur, Mohammad Bahrami; Mazaheri, Yazdan; Tabandeh, Mohammad Reza; Tabatabaei, Seyed Reza Fatemi

doi:10.4067/s0717-95022021000200577

Cited by 3 publications

(1 citation statement)

References 31 publications

(34 reference statements)

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“…Administration of A. vera gel in diabetic rats could reduce hyperglycemia and modulating nerve growth factor expression and P75 and TrkA receptors (Mahabady et al 2021 ). In addition, it inhibited hippocampal and cortical cell degeneration in diabetic mice (Parihar et al 2004 ).…”

Section: Aloe Vera and Stz-induced Diabetesmentioning

confidence: 99%

Aloe vera and Streptozotocin-Induced Diabetes Mellitus

Haghani

Arabnezhad

Mohammadi

et al. 2022

Rev. Bras. Farmacogn.

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Diabetes mellitus is defined as prolonged hyperglycemia, which can harm the eyes, kidneys, and cardiovascular and neurological systems. Herbal agents and their derived supplements have been used for treatment of diabetes mellitus as a part of integrated complementary medicine for centuries. Numerous studies have considered Aloe vera (L.) Burm.f, Xanthorrhoeaceae, as an alternative medicine due to its abundant bioactive chemicals, such as alkaloids, anthraquinones, and enthrones, with therapeutical properties including antioxidant, anti-inflammatory, neuro-protective, and anti-diabetic effects. Aloe vera has received considerable attention in traditional medicine for the treatment of several diseases including diabetes mellitus. Numerous studies have investigated the effects of herbal agents on diabetes mellitus using a streptozotocin-induced diabetic model. Thereby, this article reviews the effects of Aloe vera prescription on streptozotocin-induced diabetes mellitus to provide a clear insight into the role of this medicinal plant in several biological functions, such as antioxidant, wound healing, anti-inflammatory, anti-hyperglycemic, and anti-hyperlipidemic in diabetic models.

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Section: Aloe Vera and Stz-induced Diabetesmentioning

confidence: 99%

Aloe vera and Streptozotocin-Induced Diabetes Mellitus

Haghani

Arabnezhad

Mohammadi

et al. 2022

Rev. Bras. Farmacogn.

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Beneficial effects of dietary omega 3 polyunsaturated fatty acids on offspring brain development in gestational diabetes mellitus

Kemse,

Chhetri,

Joshi

2024

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Unveiling the Latest Breakthroughs: A Comprehensive Review of the Therapeutic Activity and Safety Profile of Aloe vera

Saifi,

Sharma,

Chaudhary

et al. 2024

CDS

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The use of herbal drugs as alternative and complementary medicine has increased in popularity, raising concerns about their safety profile. Aloe vera, a plant with diverse therapeutic properties, has been extensively used for centuries. This review aims to assess the therapeutic activity and safety profile of Aloe vera. A comprehensive literature search was conducted to gather relevant information from various biomedical databases. The chemical composition, mechanism of action, and therapeutic activities of Aloe vera were analyzed. Aloe vera contains numerous active components such as vitamins, enzymes, minerals, sugars, lignin, saponins, and anthraquinones. Its mechanisms of action involve collagen synthesis, anti-inflammatory effects, immune modulation, laxative properties, and antiviral activity. Aloe vera has demonstrated potential therapeutic benefits in wound healing, diabetes management, liver and kidney protection, and glycemic control. However, it is essential to consider potential side effects, such as skin irritation and allergic reactions. This review provides evidence-based information to improve patient safety and promote informed decisions regarding the use of Aloe vera as a therapeutic agent.

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Effect of Aloe vera on the Expression of Nerve Factors, p75 and TrkA Receptors in the Hippocampus of Diabetic Rats

Cited by 3 publications

References 31 publications

Aloe vera and Streptozotocin-Induced Diabetes Mellitus

Aloe vera and Streptozotocin-Induced Diabetes Mellitus

Beneficial effects of dietary omega 3 polyunsaturated fatty acids on offspring brain development in gestational diabetes mellitus

Unveiling the Latest Breakthroughs: A Comprehensive Review of the Therapeutic Activity and Safety Profile of Aloe vera

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