Effect of Allopurinol on Blood Pressure of Adolescents With Newly Diagnosed Essential Hypertension

The nitrite reductase activity of xanthine oxidoreductase sustains cardiovascular health as mice age

“…We suggest that this complexity arises from a lack of consideration of the full spectrum of XOR activity. Our data demonstrates that a single allele deletion of Xdh results in an elevation of BP, contrasting with suggestions that pharmacological XOR inhibition results in a small but significant lowering of BP in certain patient cohorts [ 54 , 55 ]. A potential explanation for these conflicting data is that inhibition of XOR will result in a lowering of UA and ROS production but also a loss of XOR-mediated nitrite reduction.…”

The nitrite reductase activity of xanthine oxidoreductase sustains cardiovascular health

“…We suggest that this complexity arises from a lack of consideration of the full spectrum of XOR activity. Our data demonstrates that a single allele deletion of Xdh results in an elevation of BP, contrasting with suggestions that pharmacological XOR inhibition results in a small but significant lowering of BP in certain patient cohorts 52,53 . A potential explanation for these conflicting data is that inhibition of XOR will result in a lowering of UA and ROS production but also a loss of XOR mediated nitrite reduction.…”

A Study of Lipid Profile and the Correlation of Serum Uric Acid Levels in Patients With Hypertension

“…The average age of our study participants was higher than the average age reported in the studies by Eisen et al and Grayson et al [ 23 , 24 ]. The gender ratio (male/female) in our study was 1.12:1, which was lower than the ratio of 1.5:1 reported by Feig et al [ 25 ]. The mean SBP and DBP in our patients were 137.11±25.09 and 89.41±12.76, respectively.…”