Abstract:Background. Among the drugs that have a pleiotropic effect on bone, attention is drawn to alfacalcidol – the precursor of the active form of D-hormone. There are studies that have revealed distinctive features of the effect of alfacalcidol on bone regeneration in osteoporosis and in young animals. The purpose was to study bone regeneration after treatment with alfacalcidol in senile animals. Materials and methods. A transcortical defect from the lateral to the medial femur was modeled in rats aged 24 months in… Show more
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