Effect of aging on hemodynamic response to metaboreflex activation

Milia, Raffaele; Roberto, Silvana; Mulliri, Gabriele; Loi, Andrea; Marcelli, Maura; Sainas, Gianmarco; Milia, Nicola; Marongiu, Elisabetta; Crisafulli, Antonio

doi:10.1007/s00421-015-3153-5

Cited by 36 publications

(61 citation statements)

References 42 publications

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“…From recent and early findings, it appears that the capacity to centralize blood volume and to increase venous return plays a pivotal role during the metaboreflex, and altered hemodynamic responses have been described where this capacity is impaired (4,13,33,53). In the present investigation, VFR was used to investigate venous return.…”

Section: Discussionmentioning

confidence: 92%

“…These substances can trigger cardiovascular reflexes (i.e., the so called "metaboreflex"), thereby activating the sympathetic nervous system, which in turn increases blood pressure to guarantee sufficient metabolite wash-out from the contracting muscle (19,39). In normal individuals, this task is accomplished with a complex hemodynamic response that encompasses complex interplay between myocardial performance, cardiac preload, afterload, and HR (3,6,9,13,14,24,33,40,51,56). Recent evidence suggests that, at least in healthy subjects, when the metaboreflex is activated by PEMI, a central role in the described metaboreflex-induced blood pressure response is played by the possibility to keep constant or to increase SV, thereby maintaining or increasing CO, since HR is not usually involved in the phenomenon (3, 9 -11, 25, 38).…”

Section: Discussionmentioning

confidence: 99%

“…The possibility to modulate SV has been defined crucial in the metaboreflex activation by means of PEMI, since in this setting HR does not normally have an evident response because of the elevated vagal tone, which counteracts the sympathetic activation (25,38). Thus, to increase/or to maintain stable CO values, cardiovascular regulatory mechanisms can only rely on the SV reserve, which can be recruited by enhancing cardiac performance and/or cardiac preload (11,13,29,33). In the present study, the OMS group showed a tendency to decrease SV response during the metaboreflex, whereas normal subjects increased this parameter.…”

Section: Discussionmentioning

confidence: 99%

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Differences in hemodynamic response to metaboreflex activation between obese patients with metabolic syndrome and healthy subjects with obese phenotype

Milia

Velluzzi

Roberto

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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Patients suffering from obesity and metabolic syndrome (OMS) manifest a dysregulation in hemodynamic response during exercise, with an exaggerated systemic vascular increase. However, it is not clear whether this is the consequence of metabolic syndrome per se or whether it is due to concomitant obesity. The aim of the present investigation was to discover whether OMS and noncomplicated obesity resulted in different hemodynamic responses during the metaboreflex. Twelve metabolically healthy but obese subjects (MHO; 7 women), 13 OMS patients (5 women), and 12 normal age-matched controls (CTL; 6 women) took part in this study. All participants underwent a postexercise muscle ischemia protocol to evaluate the metaboreflex activity. Central hemodynamics were evaluated by impedance cardiography. The main result shows an exaggerated increase in systemic vascular resistance from baseline during the metaboreflex in the OMS patients as compared with the other groups (481.6 ± 180.3, -0.52 ± 177.6, and -60.5 ± 58.6 dynes·s(-1)·cm(-5) for the OMS, the MHO, and the CTL groups, respectively; P < 0.05). Moreover, the MHO subjects and the CTL group showed an increase in cardiac output during the metaboreflex (288.7 ± 325.8 and 703.8 ± 276.2 ml/m increase with respect to baseline), whereas this parameter tended to decrease in the OMS group (-350 ± 236.5 ml/m). However, the blood pressure response, which tended to be higher in the OMS patients, was not statistically different between groups. The results of the present investigation suggest that OMS patients have an exaggerated vasoconstriction in response to metaboreflex activation and that this fact is not due to obesity per se

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Differences in hemodynamic response to metaboreflex activation between obese patients with metabolic syndrome and healthy subjects with obese phenotype

Milia

Velluzzi

Roberto

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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“…This protocol has been shown to trap the muscle metabolites in the exercising limb and to maintain stimulation of the metaboreceptors (Crisafulli et al, 2007, 2011; Marongiu et al, 2013). This protocol has been demonstrated to induce substantial cardiovascular activation in terms of enhancement in stroke volume (SV), SVR, cardiac contractility, and cardiac pre-load (Crisafulli et al, 2007, 2008, 2011; Roberto et al, 2012; Milia et al, 2015a). …”

Section: Methodsmentioning

confidence: 99%

“…To assess metaboreflex activity, the following procedure was employed: for each parameter, the difference between the PEMI and the CER test was calculated. This procedure allowed us to assess metaboreflex response, i.e., the response due to the metaboreflex activity (Milia et al, 2015a,b; Crisafulli et al, 2013). Differences between groups in mean ± SD of measured variables due to metaboreflex response were assessed by means of two way ANOVA for repeated measures (factors: group and time) followed by Tukey post-hoc when appropriate.…”

Section: Methodsmentioning

confidence: 99%

Effects of Six Months Training on Physical Capacity and Metaboreflex Activity in Patients with Multiple Sclerosis

et al. 2016

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Patients with multiple sclerosis (MS) have an increased systemic vascular resistance (SVR) response during the metaboreflex. It has been hypothesized that this is the consequence of a sedentary lifestyle secondary to MS. The purpose of this study was to discover whether a 6-month training program could reverse this hemodynamic dysregulation. Patients were randomly assigned to one of the following two groups: the intervention group (MSIT, n = 11), who followed an adapted training program; and the control group (MSCTL, n = 10), who continued with their sedentary lifestyle. Cardiovascular response during the metaboreflex was evaluated using the post-exercise muscle ischemia (PEMI) method and during a control exercise recovery (CER) test. The difference in hemodynamic variables such as stroke volume (SV), cardiac output (CO), and SVR between the PEMI and the CER tests was calculated to assess the metaboreflex response. Moreover, physical capacity was measured during a cardiopulmonary test till exhaustion. All tests were repeated after 3 and 6 months (T3 and T6, respectively) from the beginning of the study. The main result was that the MSIT group substantially improved parameters related to physical capacity (+5.31 ± 5.12 ml·min−1/kg in maximal oxygen uptake at T6) in comparison with the MSCTL group (−0.97 ± 4.89 ml·min−1/kg at T6; group effect: p = 0.0004). However, none of the hemodynamic variables changed in response to the metaboreflex activation. It was concluded that a 6-month period of adapted physical training was unable to reverse the hemodynamic dys-regulation in response to metaboreflex activation in these patients.

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Metaboreflex activity in multiple sclerosis patients

et al. 2015

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Effect of aging on hemodynamic response to metaboreflex activation

Abstract: This study demonstrates that diastolic function is important for normal hemodynamic adjustment during the metaboreflex and to avoid excessive vasoconstriction.

Cited by 36 publications

References 42 publications

Differences in hemodynamic response to metaboreflex activation between obese patients with metabolic syndrome and healthy subjects with obese phenotype

Differences in hemodynamic response to metaboreflex activation between obese patients with metabolic syndrome and healthy subjects with obese phenotype

Effects of Six Months Training on Physical Capacity and Metaboreflex Activity in Patients with Multiple Sclerosis

Metaboreflex activity in multiple sclerosis patients

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