“…It is conceivable that decreases in the water or fat content of the tissue would cause such a rise. Calculations based on reported values of fat and water contents of the skin and the whole animal (Lowrey, 1913;Winter, 1934;Adams, 1937;Hatai, 1917;Chanutin, 1931) show that, although such changes would contribute to the observed rise in histamine content, they cannot account for the full extent of the change or the time when it occurs.…”