Effect of Age and Anatomical Site on Density of Sensory Innervation in Human Epidermis

Besné, Isabelle; Descombes, Caroline; Breton, Lionel

doi:10.1001/archderm.138.11.1445

Cited by 126 publications

(88 citation statements)

References 38 publications

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“…In contrast, mice between 12 and 20 months of age show only mild age-related changes (fiber reduction, myelin loops, membrane irregularity). In the peripheral target, measures in human of intraepidermal nerve fiber density showed no significant change in epidermal fiber density with age, except when comparison of aged samples was made to the highest values in the youngest subjects [25,27] (though see [7,14]). In 18-month old mice, innervation to the epidermis showed only a moderate loss (10-15%) in nerve fiber density [37].…”

Section: Introductionmentioning

confidence: 94%

Reduced thermal sensitivity and Nav1.8 and TRPV1 channel expression in sensory neurons of aged mice

Wang

Davis

Zwick³

et al. 2006

Neurobiology of Aging

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Sensory neurons in aging mammals undergo changes in anatomy, physiology and gene expression that correlate with reduced sensory perception. In this study we compared young and aged mice to identify proteins that might contribute to this loss of sensation. We first show using behavioral testing that thermal sensitivity in aged male and female mice is reduced. Expression of sodium channel (Nav1.8 and Nav1.9) and transient receptor potential vanilloid (TRPV) channels in DRG and peripheral nerves of young and old male mice was then examined. Immunoblotting and RT-PCR assays showed reduced Nav1.8 levels in aged mice. No change was measured in TRPV1 mRNA levels in DRG though TRPV1 protein appeared reduced in the DRG and peripheral nerves. The GFRα3 receptor, which binds the growth factor artemin and is expressed by TRPV1-positive neurons, was also decreased in the DRG of aged animals. These findings indicate that loss of thermal sensitivity in aging animals may result from a decreased level of TRPV1 and Nav1.8 and decreased trophic support that inhibits efficient transport of channel proteins to peripheral afferents.

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Section: Introductionmentioning

confidence: 94%

Reduced thermal sensitivity and Nav1.8 and TRPV1 channel expression in sensory neurons of aged mice

Wang

Davis

Zwick³

et al. 2006

Neurobiology of Aging

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“…The first occurs immediately after the skin wound, with the conduction of electrical impulses from the injury site, in dromic direction, by the "current of injury" generation. The second component consists of neuropeptides release through nerve endings in the skin, in dromic direction [30,31].…”

Section: Discussionmentioning

confidence: 99%

Reaction time and replenishment time of SP and CGRP after incision in rat skin

et al. 2014

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Background. The skin neurogenic inflammation is mainly related to Substance P (SP) and Calcitonin Gene-related Peptide (CGRP). There is no data on their availability in the dynamics of skin nerve endings, concerning their release and replenishment after a nociceptive stimulus, so this was investigated. Materials and methods. 25 rats were randomly distributed in 5 groups. The animals of the control group (CG) determined the baseline levels of neuropeptides in the skin. The groups S0 and S30 did not receive any cutaneous stimulus at 30 and 60 minutes, respectively. In the group S1, an “incision stimulus” was made at 30 minutes. In the group S31, a nociceptive stimulus was performed by subdermal scratching at 30 minutes and, at 60 minutes, the “incision stimulus” was carried out in the same location (“nociceptive hyperstimulation”). The skin samples of the other animals were harvested from the back 1 minute after their death. SP, pro-CGRP and CGRP were quantified by Western Blotting. Results. The “incision stimulus” released SP, S1 compared to S0 (p <0.05) detected in the first minute, and the replenishment time was more than 30 minutes. Also, it cleaved pro-CGRP, S1 compared to S31 (p <0.05) in the first minute, and its replenishment time less than 30 minutes. Release of CGRP was not detected. Conclusion. The incision released SP already detected in the first minute; its replenishment time is more than 30 minutes. The incision decreased pro-CGRP, also detected in the first minute; and its replenishment time is less than 30 minutes.

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“…Along with epidermal nerve fibers, melanocytes can function as the "cutaneous nervous system" [13][14][15] . This system acts mainly in the skin, controlling inflammation, immunity, functional regulation of cutaneous structures, thermoregulation, homeostasis modulation, and wound healing 11,16 . Thus, the aggressive exposure of melanocytes to sun radiation, which affects the cutaneous nervous system, might cause pathological skin disorders, also impairing wound healing 15,17 .…”

Section: Discussionmentioning

confidence: 99%

“…In individuals of African descent, approxi mately 85% of the visible light spectrum is transformed into heat, whereas in Caucasians this percentage is 55% 11,15 . Therefore, natural or acquired variations in the constitutive pigmentation might vary the physiology of the skin and consequently, the healing process 15,16 . However, these data are not applicable to individuals of intermediate skin tones, thus justifying the necessity for new criteria to study the effect of sun exposure on the skin of all people in this group.…”

Section: Discussionmentioning

confidence: 99%

Distribuição de queloide e cicatriz hipertrófica segundo fototipos de pele de Fitzpatrick

Hochman¹,

Farkas²,

Isoldi³

et al. 2012

Rev. Bras. Cir. Plást.

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Background: Keloid and hypertrophic scars have a common physiopathogenic origin and are defined as fibroproliferative scars. Fibroproliferative scars are frequent in indivi duals with darker skin. However, mixing of "races" renders it difficult to group patients with different skin tones according to morphological and static classifications (white for Caucasians; brown for individuals of Spanish descent (Hispanic/Latino); yellow for indi viduals of East Asian descent; and black for individuals of African descent) according to their response to sun exposure. It is known that when individuals whose ethnic origin is in colder countries move to tropical countries, they show a higher incidence of these types of scars, which mainly affect parts of the body that are more exposed to the sun. A correlation between fibroproliferative scars and Fitzpatrick phototype, a dynamic classification based on the skin's response to sun exposure, would contribute to an understanding of the patho physiology of these scars. The aim of this study is to investigate the distribution of fibro proliferative scars according to Fitzpatrick phototypes. Methods: We classified patients' fibroproliferative scars according to the Muir classification as Long-Term Evolution (keloid scars), Short-Term Evolution (hypertrophic scars), and Intermediate Group (mixed scars), while their skin types were grouped according to the Fitzpatrick classification. Results: Fitzpatrick phototype III and mixed scars were predominant among the patients analyzed (p = 0.001). A correlation (p = 0.025) was observed between fibroproliferative scars and Fitzpatrick phototypes; the higher the phototype, the higher the tendency to develop keloid and mixed scar tissue. Conclusions: Fitzpatrick skin phototypes proved to be an efficient method to study keloid and hypertrophic scars.Keywords: Keloid. Cicatrix, hypertrophic. Skin pigmentation. Melanocytes. Ultraviolet rays. RESUMO Introdução:Queloide e cicatriz hipertrófica são cicatrizes patológicas com natureza fi siopatogênica comum, denominadas, em conjunto, cicatrizes fibroproliferativas. São mais frequentes em indivíduos de pele mais escura. Contudo, a atual miscigenação dificulta o enquadramento dos pacientes com variadas tonalidades de pele em classificações morfo lógicas e estáticas (branco ou caucasoide, mulato, pardo, hispânico ou latino, amarelo ou oriental ou mongoloide e negro ou negroide), e diferentes quanto à exposição solar. Sabe -se que pessoas oriundas de países de clima temperado ou frio quando residem em países

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Effect of Age and Anatomical Site on Density of Sensory Innervation in Human Epidermis

Cited by 126 publications

References 38 publications

Reduced thermal sensitivity and Nav1.8 and TRPV1 channel expression in sensory neurons of aged mice

Reduced thermal sensitivity and Nav1.8 and TRPV1 channel expression in sensory neurons of aged mice

Reaction time and replenishment time of SP and CGRP after incision in rat skin

Distribuição de queloide e cicatriz hipertrófica segundo fototipos de pele de Fitzpatrick

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