Effect of Afghan Saffron (Crocus sativus L.) Aqueous Extract on Withdrawal Signs in Morphine-Dependent Rats

Akbari, Elham; Alami, Kawsar; Hossaini, Dawood; Nazari, Mohammad Latif; Salehi, Mohammad Hossein; Sajjadi, Meysam; Mousavi, Sayed Yousof

doi:10.5530/pj.2020.12.234

Cited by 6 publications

(14 citation statements)

References 36 publications

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“…Researchers all over the world are also focused on the effect of medicinal plants and their constituents on diabetes, because of their fewer side effects than synthetic drugs. [12][13][14] In traditional medicine, it is recommended to use herbs combinations, because there are some reports that multiple herbs combinations have more effects than individual herbs. [15] Many researchers consider the combination therapy as a new and effective therapeutic strategy for controlling hyperglycemia.…”

Section: Introductionmentioning

confidence: 99%

Effect of Rheum Ribes and Urtica Dioica on type 2 diabetic rats

Hussaini¹,

Askndari²,

Alami³

et al. 2021

Int j pharm phytopharm res

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The prevalence of type 2 diabetes is increasing and considered a major cause of mortality in the world. Medicinal plants are a part of complementary and alternative medicine, which have wide use in the treatment of diabetes. Besides, combination therapy as an effective therapeutic strategy is highly recommended for controlling hyperglycemia. The present study aimed to determine the hypoglycemic effect of Afghan Rheum Ribes L. and Urtica Dioica L. extracts either alone or in combination on blood glucose level in type 2 diabetic rats. Diabetes was induced by single-dose administration of Streptozotocin (50 mg/kg) in rats. Diabetic rats were received intraperitoneal administration of R. Ribes aqueous extract (40 and 60 mg/kg), U. Dioica aqueous-alcoholic extract (100 and 200 mg/kg), and their combination for 21 days. The fasting blood glucose and body weight of rats were determined on 0, 7 th , 14 th , and 21 st days. The results showed that R. Ribes extract (40 and 60 mg/kg), U. Dioica extract (200 mg/kg), and their combination could significantly decrease the blood glucose level on 0, 7 th , 14 th , and 21 st days (P<0.0001). Only 200 mg/kg of U. Dioica had a positive effect on the bodyweight loss of diabetic rats (P<0.01). It can be concluded that Afghan R. Ribes and U. Dioica extracts and their combination have a hypoglycemic effect. However, their combinations do not show any synergic or antagonistic effects.

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Section: Introductionmentioning

confidence: 99%

Effect of Rheum Ribes and Urtica Dioica on type 2 diabetic rats

Hussaini¹,

Askndari²,

Alami³

et al. 2021

Int j pharm phytopharm res

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“…However, adverse side effects and toxicity of these synthetic drugs increases the tendency of using natural remedies in treatment of many disorders. Many natural products such as p l a n t s , f r u i t s a n d n u t s h a v e p o t e n t i a l pharmacological activities (8)(9)(10)(11)(12)(13). Also, because of economic problems and the lack of some synthetic drugs in developing countries, the usage of medicinal plants in such countries is increasing (14).…”

Section: Introductionmentioning

confidence: 99%

Effect of Afghan Talkhak (Acroptilon Repens) Aqueous Extract on Blood Glucose Level in Diabetic Rats

Bayat¹,

Alami²,

Mousavi³

2021

IJAM

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The aim of this study is the evaluation of the effect of Afghan talkhak (Acroptilon Repens) root aqueous extract on blood glucose level of diabetic rats. Rats were randomly divided into 5 groups (1 Normal, 1 Diabetic and 3 extract groups). Experimental diabetes was induced by single-dose intraperitoneal (i.p.) injection of streptozotocin (55 mg/kg) in diabetic and extracts groups. 72 hour later, the induction of diabetes was approved and extract groups were received Acroptilon Repens aqueous extract (200, 300, 400 mg/kg) by i.p. administration for 15 days. The blood glucose level and body weight of all groups were measured on baseline, 0, 5, 10 and 15th days. The glucose tolerance test had performed on days 0 and 15. The results showed that aqueous extract of Afghan Acroptilon Repens in extract groups (200 and 300 mg/kg) could significantly decrease the blood glucose level, and improve the glucose tolerance, as compared with the diabetic group (P<0.0001). However, there was not a significant difference in the blood glucose level and glucose tolerance test among the group which received 400 mg/kg dose of Acroptilon Repens and the diabetic group (P>0.05). In conclusion, Acroptilon Repens root aqueous extract possessed antihyperglycemic activity.

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“…This plant is also known as kings of the world's medicines. Crocus sativus mainly contains crocin, picrocrocin and safranal [36,37]. It has many pharmacological effects such as anti-oxidant [35], memory-enhancing [38], anti-inflammatory and anti-nociceptive [39].…”

Section: Introductionmentioning

confidence: 99%

“…It has many pharmacological effects such as anti-oxidant [35], memory-enhancing [38], anti-inflammatory and anti-nociceptive [39]. In addition, this plant has beneficial effects on morphine dependency treatment and reduction of morphine withdrawal signs [37,40]. Previous studies have related the effects of this plant on morphine withdrawal to its main constituent, crocin, which can decrease the morphine withdrawal signs [40].…”

Section: Introductionmentioning

confidence: 99%

Effect of Afghan Ferula assa-foetida L. and Crocus Sativus L. Aqueous Extracts Combination on Withdrawal Signs in Morphine-Dependent Rats

Yousofi¹,

Alami²,

Mousavi³

2021

app

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The purpose of this study is to evaluate the effect of Afghan Ferula assa-foetida L. and Crocus Sativus L. aqueous extracts either alone or in combination on morphine withdrawal signs. For this purpose, rats were randomly divided into 13 groups (1 Normal, 1 Morphine, 4 Ferula assa-foetida-treated groups, 4 Crocus sativus-treated groups, and 3 combination groups). Morphine dependency was rendered by subcutaneous injection of morphine hydrochloride for 4 days (10, 20 and 40 mg/kg doses twice daily for 3 days and a single dose of 60 mg/kg on 4th day). Various doses of extracts were injected into extract groups simultaneously with morphine. After two hours of last morphine administration, withdrawal signs were induced by naloxone (3 mg/kg) and noted for 30 minutes. According to the results, different doses of Ferula assa-foetida and Crocus sativus extracts and their combination (in low dose) could significantly decrease the number of morphine withdrawal signs (P<0.05). However, the combination of Ferula assa-foetida and Crocus sativus extracts in high doses showed toxic effects. In conclusion, Ferula assa-foetida and Crocus sativus extract combination in low dose can decrease the morphine withdrawal signs, but without any synergic effects.

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Effect of Afghan Saffron (Crocus sativus L.) Aqueous Extract on Withdrawal Signs in Morphine-Dependent Rats

Cited by 6 publications

References 36 publications

Effect of Rheum Ribes and Urtica Dioica on type 2 diabetic rats

Effect of Rheum Ribes and Urtica Dioica on type 2 diabetic rats

Effect of Afghan Talkhak (Acroptilon Repens) Aqueous Extract on Blood Glucose Level in Diabetic Rats

Effect of Afghan Ferula assa-foetida L. and Crocus Sativus L. Aqueous Extracts Combination on Withdrawal Signs in Morphine-Dependent Rats

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