Effect of acid secretion blockade on acute gastric mucosal lesions induced by Tityus serrulatus scorpion toxin in anaesthetized rats

Melo, J.R. Cunha; Araújo, Gnana Keith Marques de; Luz, Magda Maria Profeta da; Conceição, Sérgio Alexandre da; Lisboa, Felipe A.; Moraes-Santos, Tasso; Cunha-Melo, José Renan

doi:10.1016/j.toxicon.2006.07.003

Toxicon

2006

DOI: 10.1016/j.toxicon.2006.07.003

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Effect of acid secretion blockade on acute gastric mucosal lesions induced by Tityus serrulatus scorpion toxin in anaesthetized rats

J.R. Cunha Melo

Gnana Keith Marques de Araújo

Magda Maria Profeta da Luz

et al.

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Cited by 3 publications

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“…However, to date it is still controversial about relationship between the acid output and the genesis of acute gastric mucosal lesions (AGML). Our results support this correlation as anise suspension significantly reduced basal gastric secretion and prevented the occurrence of AGML in pylorus-ligated rats and thus, supporting the hypothesis of "no acid no ulcer" [39] . It has been postulated that histamine may be involved in the formation of pylorus-ligated ulcers and play a mediating role in the gastric secretion stimulated by gastrin, vagal stimulation, and cholinergic agents [40] .…”

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confidence: 87%

Aqueous suspension of anise “Pimpinella anisum” protects rats against chemically induced gastric ulcers

Mofleh

Alhaider²,

Mossa³

et al. 2007

WJG

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INTRODUCTIONPeptic ulcer is one of the most common gastrointestinal diseases. Nowadays proton pump inhibitors and H2-recptor antagonists are the most widely used drugs to treat peptic ulcer disease. However, the use of these antisecretory drugs may be associated with adverse events and ulcer relapse [1] . Thus, there is a need for more effective, less toxic and cost-effective anti-ulcer agents. In recent years, a widespread search has been launched to identify new anti-ulcer drugs from natural sources. Spices comprising the most important products used for flavouring foods and medicinal herbs are considered nowadays as potential bioactive agents that can interfere positively or negatively with different cellular processes. They are extensively used in medicine, pharmaceuticals, perfumery and cosmetics. Additionally they possess antioxidant, antispasmodic, carminative, anti-inflammatory and other properties [2] . A number of spices, namely large cardamom [3] , black pepper [4] , caraway [5] , cardamom [6] , clove [7] , coriander [8] , ginger [9] , peppermint [10] , saffron [11] , turmeric [12] among others have been shown to possess significant gastroprotective activities. The fruits of anise plant, pimpinella anisum L. are locally known as aniseed and yansoon. The powder and concoction of anise in hot water are used as carminatives, antiseptics, diuretics, digestives, aphrodisiacs, and as a remedy for insomnia and constipation [13] . Furthermore, anise is used to promote digestion, improve appetite, alleviate cramps and nausea, and relieve flatulence and colic. In Unani and Arabian traditional medicine, anise fruit and its oil have been used for the treatment of various conditions including dyspepsia, nausea, abdominal colic, RAPID COMMUNICATIONAqueous suspension of anise "Pimpinella anisum " protects rats against chemically induced gastric ulcers Ibrahim Abstract AIM:To substantiate the claims of Unani and Arabian traditional medicine practitioners on the gastroprotective potential effect of a popular spice anise, "Pimpinella anisum L." on experimentally-induced gastric ulceration and secretion in rats. METHODS:Acute gastric ulceration in rats was produced by various noxious chemicals including 80% ethanol, 0.2 mol/L NaOH, 25% NaCl and indomethacin. Anti-secretory studies were undertaken using pylorusligated Shay rat technique. Levels of gastric non-protein sulfhydryls (NP-SH) and wall mucus were estimated and gastric tissue was also examined histologically. Anise aqueous suspension was used in two doses (250 and 500 mg/kg body weight) in all experiments. RESULTS:Anise significantly inhibited gastric mucosal damage induced by necrotizing agents and indomethacin. The anti-ulcer effect was further confirmed histologically. In pylorus-ligated Shay rats, anise suspension significantly reduced the basal gastric acid secretion, acidity and completely inhibited the rumenal ulceration. On the other hand, the suspension significantly replenished ethanol-induced depleted levels of gastric mucosal NP-SH a...

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supporting

confidence: 87%

Aqueous suspension of anise “Pimpinella anisum” protects rats against chemically induced gastric ulcers

Mofleh

Alhaider²,

Mossa³

et al. 2007

WJG

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Immune cells recruitment and activation by Tityus serrulatus scorpion venom

Fialho

Maciel

Silva

et al. 2011

Toxicon

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Tityus serrulatus venom – A lethal cocktail

Pucca

Cerni

Pinheiro-Júnior

et al. 2015

Toxicon

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Effect of acid secretion blockade on acute gastric mucosal lesions induced by Tityus serrulatus scorpion toxin in anaesthetized rats

Cited by 3 publications

References 53 publications

Aqueous suspension of anise “Pimpinella anisum” protects rats against chemically induced gastric ulcers

Aqueous suspension of anise “Pimpinella anisum” protects rats against chemically induced gastric ulcers

Immune cells recruitment and activation by Tityus serrulatus scorpion venom

Tityus serrulatus venom – A lethal cocktail

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