Effect of a single dose of Saccharomyces cerevisiae var. boulardii on the occurrence of porcine neonatal diarrhoea

Hancox, Laura R.; Bon, M Le; Richards, Philip J.; Guillou, Dounia Le; Dodd, C.E.R.; Mellits, Kenneth H.

doi:10.1017/s1751731114002687

Cited by 29 publications

(27 citation statements)

References 18 publications

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“…Table 3). In addition, Equations (4) and (5) confirmed the increased growth rates achieved by Sc b in comparison to Sc. Indeed, these equations estimated significant s 2 parameter values (p-value < 2 × 10 −16 ) for Sc b and Sc respectively, corresponding to different growth rates for both yeast species.…”

Section: Yeast Growth Analysis In Bioreactor Culturementioning

confidence: 58%

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Saccharomyces Cerevisiae Var. Boulardii: Valuable Probiotic Starter for Craft Beer Production

2019

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The use of probiotic starters remaining viable in unpasteurized and unfiltered beers could significantly increase health benefits. Here, the probiotic Saccharomyces cerevisiae var. boulardii (Sc b ) and a commercial Saccharomyces cerevisiae (Sc) strain, which is commonly employed in the brewing industry, are compared as single starters. The healthy value of the produced beers and growth performance in a laboratory bioreactor are analysed by determining antioxidant activity, phenolic content and profile, alcohol, biomass growth modelling by the logistic and Gompertz equations, biovolume estimation from 2D microscopy images, and yeast viability after fermentation. Thus, in this study, the craft beer produced with the probiotic yeast possessed higher antioxidant activity, lower alcohol content, similar sensory attributes, much higher yeast viability and more acidification, which is very desirable to reduce contamination risks at large-scale production. Furthermore, Sc b exhibited faster growth in the bioreactor culture and larger cell volumes than Sc, which increases the probiotic volume of the final craft beer. associated diarrhea [10,11] and may help to eradicate Helicobacter pylori [12]. In fact, the Sc b yeast is now commercially available in most countries globally.Sc b shows enhanced ability for pseudohyphal switching upon nitrogen limitation and increased resistance to acidic pH, which are not correlated with increased adherence to epithelial cells or transit through mouse gut [13]. However, a recent genetic comparative study of 5 Sc b against 145 Sc yeast strains has revealed the presence of two genes, HXT11 and HXT9, in Sc, which are not present in Sc b [14]. The absence of these genes has been related to greater resistance against several antifungals, such as cycloheximide, sulfometuron methyl and 4-nitroquinoline-N-oxide [15]. Other genetic particularities that have been reported for Sc b include the absence of ASP3 genes involved in asparagine degradation [16] and the abundant repetition of Flocculatıon (FLO) genes, which could explain the ability of Sc b to adhere to the intestinal epithelium [17,18].The optimal growth temperature of Sc b is 37 • C and thus it can reach very high gastrointestinal tract (GT) concentrations in a very short period [19]. In addition, it possesses the capacity to inhibit the growth, adherence and invasion of multiple pathogens such C. difficile [20], E. coli [21], and Candida albicans [22], both in in vitro and in vivo conditions to the epithelial layer of the GT.In recent years, there has been a worldwide increase in the consumer interest in craft beers, which are unpasteurized, unfiltered and without additional nitrogen or carbon dioxide pressure [23]. Even though there are many controversial studies about the beneficial effects of beer consumption on human health, epidemiological studies have shown that beer has positive effects on cardiovascular protection inhibiting atherosclerosis, decreasing the content of serum low-density lipoprotein cholesterol and triglycerides, b...

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Section: Yeast Growth Analysis In Bioreactor Culturementioning

confidence: 58%

“…Saccharomyces cerevisiae var. boulardii (Sc b ) is another popular yeast species that was isolated from fruit in Indochina and has been utilised as a remedy for diarrhea since 1950 [4,5]. Sc b has shown a capacity to prevent travellers' diarrhea usually caused by bacteria such as Escherichia coli and Salmonella sp.…”

Section: Introductionmentioning

confidence: 99%

Saccharomyces Cerevisiae Var. Boulardii: Valuable Probiotic Starter for Craft Beer Production

2019

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“…Moreover, aerobic and facultative anaerobic bacteria contribute to the consumption of oxygen in the intestine, which can promote the colonization of strict anaerobes [21,22]. Saccharomyces boulardii (S. boulardii) is an aerobic yeast [23], and early intervention with S. boulardii can alleviate porcine neonatal diarrhea [24,25]. Clostridium butyricum (C. butyricum) is a probiotic and has been used for the clinical treatment of premature infants with diarrhea by promoting the maturation of the immune function [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Early-Life Intervention Using Fecal Microbiota Combined with Probiotics Promotes Gut Microbiota Maturation, Regulates Immune System Development, and Alleviates Weaning Stress in Piglets

Xiang

Pan

et al. 2020

IJMS

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Previous studies have suggested that immune system development and weaning stress are closely related to the maturation of gut microbiota. The early-life period is a "window of opportunity" for microbial colonization, which potentially has a critical impact on the development of the immune system. Fecal microbiota transplantation (FMT) and probiotics are often used to regulate gut microbial colonization. This study aims to test whether early intervention with FMT using fecal microbiota from gestation sows combined with Clostridium butyricum and Saccharomyces boulardii (FMT-CS) administration could promote the maturation of gut microbiota and development of immune system in piglets. Piglets were assigned to control (n = 84) and FMT-CS treatment (n = 106), which were treated with placebo and bacterial suspension during the first three days after birth, respectively. By 16S rRNA gene sequencing, we found that FMT-CS increased the α-diversity and reduced the unweighted UniFrac distances of the OTU community. Besides, FMT-CS increased the relative abundance of beneficial bacteria, while decreasing that of opportunistic pathogens. FMT-CS also enhanced the relative abundance of genes related to cofactors and vitamin, energy, and amino acid metabolisms during the early-life period. ELISA analysis revealed that FMT-CS gave rise to the plasma concentrations of IL-23, IL-17, and IL-22, as well as the plasma levels of anti-M.hyo and anti-PCV2 antibodies. Furthermore, the FMT-CS-treated piglets showed decreases in inflammation levels and oxidative stress injury, and improvement of intestinal barrier function after weaning as well. Taken together, our results suggest that early-life intervention with FMT-CS could promote the development of innate and adaptive immune system and vaccine efficacy, and subsequently alleviate weaning stress through promoting the maturation of gut microbiota in piglets.

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“…Host genetics plays a major role in shaping the intestinal microbiota of mice and humans (Büsing and Zeyner, 2015; Dąbrowska and Witkiewicz, 2016; Hancox et al, 2015). Chen et al (2018), Kubasova et al (2018) and Lu et al (2018) reported the impact of host genetics on development of gut microbiota in pigs.…”

Section: Resultsmentioning

confidence: 99%

Microbiability of meat quality and carcass composition traits in swine

Khanal

Maltecca

Schwab³

et al. 2019

Preprint

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The impact of gut microbiome composition was investigated at different stages of production (Wean, Mid-test, and Off-test) on meat quality and carcass composition traits of 1,123 three-way-crossbred pigs. Data were analyzed using linear mixed models which included the fixed effects of dam line, contemporary group and gender as well as the random effects of pen, animal and microbiome information at different stages. The contribution of the microbiome to all traits was prominent although it varied over time, increasing from weaning to Off-test for most traits. Microbiability estimates of carcass composition traits were greater compared to meat quality traits. Adding microbiome information did not affect the estimates of genomic heritability of meat quality traits but affected the estimates of carcass composition traits. High microbial correlations were found among different traits, particularly with traits related to fat deposition with decrease in genomic correlation up to 20% for loin weight and belly weight. Decrease in genomic heritabilities and genomic correlations with the inclusion of microbiome information suggested that genomic correlation was partially contributed by genetic similarity of microbiome composition.

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Effect of a single dose of Saccharomyces cerevisiae var. boulardii on the occurrence of porcine neonatal diarrhoea

Cited by 29 publications

References 18 publications

Saccharomyces Cerevisiae Var. Boulardii: Valuable Probiotic Starter for Craft Beer Production

Saccharomyces Cerevisiae Var. Boulardii: Valuable Probiotic Starter for Craft Beer Production

Early-Life Intervention Using Fecal Microbiota Combined with Probiotics Promotes Gut Microbiota Maturation, Regulates Immune System Development, and Alleviates Weaning Stress in Piglets

Microbiability of meat quality and carcass composition traits in swine

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