Effect of a Selenium-Deficient Diet on Blood Values of T3 and T4 in Cows

Contreras, P. A.; Matamoros, Roberto; Monroy, R.; Kruze, J.; Leyan, V.; Andaur, Marcela; ̈Hmwald, H. Bo; Wittwer, F

doi:10.1007/s005800200000

Cited by 9 publications

(4 citation statements)

References 15 publications

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“…It could be hypothesised that I could probably be the other necessary mineral (Van Ryssen et al., 1999). Thus, an I content in pasture of less than 0.1 mg/kg dry matter causes goitre in lambs (Mason, 1976) and an increase in T4 levels in the serum (Contreras et al., 2002). As with Se, I content in pasture can also present important variabilities and, frequently, Se and I were deficient in sheep fed on grass inland versus those reared in coastal areas (Sivertsen et al., 2014).…”

Section: Introductionmentioning

confidence: 99%

“…These factors affect the uptake of Se and I content in edible plants, which subsequently affects their nutritional availability for animals and humans (Reis et al., 2017). Besides, there are some iatrogenic plants containing thiocyanates, such as Panicum and Paspalum , or containing glucosynolates, such as Cichorium (Mufarrege, 2007), that could be responsible for I deficiency in grazing sheep, whereas Se deficiency causes a decrease in T3 levels and an increase in T4 in blood (Contreras et al., 2002). Simultaneously, a deficiency in I is also observed (Berger, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Se and I status in pregnant ewes from a pastoral system and the effect of supplementation with Se and I or only Se on wool quality of lambs

Guerra

Cabrera

Abella

et al. 2019

Heliyon

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Australian Merino ewes and lambs producing fine fibre wool for export are raised in the north-west of Uruguay in pasture-based systems. We studied the status of selenium and iodine in pregnant Merino ewes (10 per treatment) grazing in natural pasture, in natural pasture and supplemented with Se (0.1 mg Se/kg dry matter intake) and I (1 mg I/kg dry matter intake), or in natural pasture and supplemented with Se alone (0.1 mg Se/kg dry matter intake), during the last 30 days of gestation. Further, we evaluated the performance and wool quality of their offspring. Content of Se and I in natural pasture, in the sera of pregnant ewes, and in the wool of their offspring and levels of thyroidal hormones—TSH, T4, and free T3 (FT3)—in the sera of pregnant ewes were determined. The performance of lambs and the commercial parameters of fine fibre wool produced were measured. Results showed normal Se levels in serum (0.12–0.15 mg/l) in the ewes grazing in natural pasture (0.07–0.09 mg/kg DM) during late pregnancy. The observed increase in Se content in the pasture at lambing (0.11–0.16 mg/kg DM) improved serum Se levels (0.216 mg/l); however, the serum levels were not affected by the supplementation.I content in pasture showed adequate levels (0.50–0.60 mg/kg DM), which were reflected in the blood serum values 30 days prior to lambing (0.197–0.208 mg/l). However, at lambing, the I content in blood serum decreased (0.150 mg/l). Further, the supplementation did not modify the serum I levels (0.163–0.175 mg/l). An increase in FT3 levels in ewes at lambing could be associated with the increase in Se content in pasture and/or the adequate I content in pasture. No effect of supplementation was observed. Lambs showed good results regarding the quality of fine fibre wool and performance after supplementation with Se and I or Se alone and exhibited slightly improved Se and I content in wool. In conclusion, natural pasture provides adequate status in Se and I for the Merino ewes and their offspring without any additional beneficial effects of supplementation with Se and I or only Se.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Se and I status in pregnant ewes from a pastoral system and the effect of supplementation with Se and I or only Se on wool quality of lambs

Guerra

Cabrera

Abella

et al. 2019

Heliyon

View full text Add to dashboard Cite

show abstract

“…The metabolic balance of Se in cows was evaluated by the blood activity of glutathione peroxidase (GPx) using a commercial reagent (Ransel®, Randox), according to Contreras et al (2002). The activity of GPx was expressed in U/g of hemoglobin (Hb).…”

Section: Selenium Metabolic Balance Evaluationmentioning

confidence: 99%

“…All deiodinases contain a residue of selenocysteine in their active site (Stadtman, 2000), therefore an adequate metabolic balance of selenium (Se) is essential for synthesis, activation, metabolism, and secretion of thyroid hormones. An insufficient supply of Se in ruminants compromises the metabolism of thyroid hormones affecting the conversion of T4 to T3 (Contreras et al, 2002;Voudouri et al, 2003;Rowntree et al, 2004) and that calves born to mothers with negative metabolic balances of Se do not only have compromised their Se status but also the neonatal synthesis of thyroid hormones (Awadeh et al, 1998;Guyot et al, 2011). To correct or control clinical signs of deficiency, it is common to resort to inorganic Se sources (e.g.…”

Section: Introductionmentioning

confidence: 99%