2019
DOI: 10.1001/jama.2019.0071
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Abstract: IMPORTANCE Abnormal peripheral perfusion after septic shock resuscitation has been associated with organ dysfunction and mortality. The potential role of the clinical assessment of peripheral perfusion as a target during resuscitation in early septic shock has not been established. OBJECTIVE To determine if a peripheral perfusion-targeted resuscitation during early septic shock in adults is more effective than a lactate level-targeted resuscitation for reducing mortality. DESIGN, SETTING, AND PARTICIPANTS Mult… Show more

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Cited by 489 publications
(399 citation statements)
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References 36 publications
(116 reference statements)
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“…DSI was calculated as the quotient between HR and DAP registered just before the start of vasopressor therapy (Pre-VPs/DSI) in the preliminary cohort and at the randomization point in the ANDROMEDA-SHOCK population (< 4 h of septic shock diagnosis according to inclusion criteria), i.e., VPs/DSI [21]. Then, DSI was subsequently calculated 2, 4, and 8 h after the introduction of vasopressor support in both populations.…”
Section: Methodsmentioning
confidence: 99%
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“…DSI was calculated as the quotient between HR and DAP registered just before the start of vasopressor therapy (Pre-VPs/DSI) in the preliminary cohort and at the randomization point in the ANDROMEDA-SHOCK population (< 4 h of septic shock diagnosis according to inclusion criteria), i.e., VPs/DSI [21]. Then, DSI was subsequently calculated 2, 4, and 8 h after the introduction of vasopressor support in both populations.…”
Section: Methodsmentioning
confidence: 99%
“…A total of 761 patients were analyzed: a preliminary cohort of 337 patients with sepsis requiring vasopressor support (January 2015 to February 2017) from one mixed-ICU in a university hospital in Colombia (Fundación Valle del Lili, Cali, Colombia) and 424 patients with septic shock included in a recent randomized controlled study (March 2017 to April 2018) conducted in 28 hospitals in 5 countries (Argentina, Chile, Colombia, Ecuador, Uruguay), the ANDROMEDA-SHOCK trial [21]. The respective ethical and research committee involving human beings approved the use of the data obtained in both the initial cohort (Protocol number 1238, IRB/EC approval number 099-2018, Fundación Valle del Lili, Cali, Colombia) and the randomized controlled trial [21].…”
Section: Study Populationmentioning
confidence: 99%
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“…For example, considerable online discussion followed the publication of the MERINO trial in JAMA, leading investigators to respond in a series of tweets (from a Twitter handle they created for the trial) . Another recent example was that within hours of the publication of the ANDROMEDA‐SHOCK trial, researchers re‐analyzed the results of the trial using a different statistical method and arrived at totally different conclusions …”
Section: Developing a Social Media Strategymentioning
confidence: 99%
“…38,39 Another recent example was that within hours of the publication of the ANDROMEDA-SHOCK trial, researchers re-analyzed the results of the trial using a different statistical method and arrived at totally different conclusions. 40,41 When it comes to determining which individuals to follow on Personality is often a matter of personal preference, as some users may prefer to follow individuals who are clever or witty in their commentary, or those who share a mixture of personal and professional content. Others may wish to only follow those individuals whose focus is on clinical practice or research.…”
Section: Using Social Media For Learning and Professional Developmentmentioning
confidence: 99%