Effect of a Guaiazulene-Containing Ointment on Nipple and Areola Area Health of Women

Abstract

Guaiazulene-containing ointments are routinely used for breast care during breastfeeding. It has also been proposed that nipple and areola area of non-breastfeeding women might benefit from use of this azulene. In a study with 51 women, it was investigated whether the use of a guaiazulene-containing ointment (Garmastan ® ) would improve look, elasticity and sensitivity of nipple and areola area within 4 month daily application. About one third of study participants reported improvement in sensitivity, elasticity and look of the investigated area of the breast. Assessment of doctors revealed a clear improvement in elasticity and sensitivity of the nipple and areola area over study period. Nearly all women wished to continue the use of the ointment after end of the study. In conclusion, the use of Garmastan ® ointment is able to improve sensitivity and elasticity of the nipple and areola area of the breasts of non-breastfeeding women.

Effects of Guaiazulene on Lipid Peroxidation and Antioxidant Defense System in <i>Drosophila melanogaster</i>

“…Gua, which is a cosmetic colorant approved by the FDA (Food and Drug Administration) in the USA, is used in skin -body care products, toothpaste, hair dyes, eye solutions, in the treatment of nipple irritation in nursing mothers and also to relieve itching caused by dry skin. In addition, photodynamic activation of Gua has been determined to suppress inflammation in peripheral blood mononuclear cells [4][5][6]. Azulene (AZ), a polycyclic aromatic hydrocarbon, and its derivatives, especially Gua, attract attention due to their various biological activities [7,8].…”