Effect of a bonding agent on in vitro biochemical activities of remineralizing resin-based calcium phosphate cements

Dickens, Sabine H.; Flaim, Glenn M.

doi:10.1016/j.dental.2008.02.004

Cited by 33 publications

(44 citation statements)

References 12 publications

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“…In vitro [6,7] and in vivo [3,4] studies demonstrated that remineralisation may be achieved by increasing the mineral content and the mechanical properties (i.e. hardness and modules of elasticity) of dental hard tissues.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of novel resin bonding systems containing bioactive glasses on mineral-depleted areas within the bonded-dentine interface

Sauro

Osorio

Watson

et al. 2012

J Mater Sci: Mater Med

125

108

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This study aimed in evaluating the effects of two experimental resin bonding systems containing conventional Bioglass 45S5 (BAG) or Zinc-polycarboxylated bioactive glass (BAG-Zn) micro-fillers on the resin-bonded dentine interface after storage in a simulated body fluid solution (SBFS). Three resin bonding systems were formulated: Resin-A: (BAG containing); Resin-B; (BAG-Zn containing); Resin-C (no filler). The ability of the experimental resins to evoke apatite formation was evaluated using confocal Raman spectroscopy. Acid-etched dentine specimens were bonded, and prepared for AFM/nano-indentation analysis in a fully-hydrated status to evaluate the modulus of elasticity (Ei) and hardness (Hi) across the interface at different SBFS storage periods. Further resin-dentine specimens were tested for microtensile bond strength after 24 h or 3 months of SBFS storage. SEM examination was performed after de-bonding and confocal laser microscopy was used to evaluate the ultramorphology of the interfaces and micropermeability. The resin A and B showed a consistent presence of apatite (967 cm(-1)), reduced micropermeability within the resin-dentine interface and a significant increase of the Ei and Hi along the bonded-dentine interface after prolonged SBFS storage. Bond strength values were affected by the resin system (P < 0.0001) and by storage time (P < 0.0001) both after 24 h and 3 months of SBFS storage. In conclusion, resin bonding systems containing bioactive fillers may a have therapeutic effect on the nano-mechanical properties and sealing ability of mineral-depleted resin-dentine interface.

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Section: Introductionmentioning

confidence: 99%

Therapeutic effects of novel resin bonding systems containing bioactive glasses on mineral-depleted areas within the bonded-dentine interface

Sauro

Osorio

Watson

et al. 2012

J Mater Sci: Mater Med

125

108

View full text Add to dashboard Cite

show abstract

“…Thus, the purpose of the present study was to determine if biomimetic analogs may be incorporated in MTA, a clinically-acceptable, radiopaque Portland cement-based material for remineralization of artificial caries-like dentin. Specifically, as dentin remineralization with calcium phosphate resin cements is adversely affected by dentin adhesive application [30], the effects of dentin remineralization with biomimetic analogs-incorporated MTA in the presence or absence of dentin bonding were evaluated. The null hypothesis tested was that the dentin remineralization efficacy of MTA in simulated body fluid is not affected by the incorporation of biomimetic analogs or adhesive application.…”

Section: Introductionmentioning

confidence: 99%

Remineralization of artificial dentinal caries lesions by biomimetically modified mineral trioxide aggregate

Niu

et al. 2012

Acta Biomaterialia

102

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Fluoride-releasing restorative materials are available for remineralization of enamel and root caries. However, dentin remineralization is more difficult than enamel remineralization due to the paucity of apatite seed crystallites along the lesion surface for heterogeneous crystal growth. Extracellular matrix proteins play critical roles in controlling apatite nucleation/growth in collagenous tissues. This study examined the remineralization efficacy of mineral trioxide aggregate (MTA) in phosphate-containing simulated body fluid (SBF) by incorporating polyacrylic acid and sodium tripolyphosphate as biomimetic analogs of matrix proteins for remineralizing caries-like dentin. Artificial caries-like dentin lesions incubated in SBF were remineralized over a 6-week period using MTA or MTA containing biomimetic analogs in the absence or presence of dentin adhesive application. Lesion depths and integrated mineral loss were monitored with micro-computed tomography. Ultrastructure of baseline and remineralized lesions were examined by transmission electron microscopy. Dentin remineralization was best achieved using MTA containing biomimetic analogs regardless of whether an adhesive was applied; dentinal tubules within the remineralized dentin were occluded by apatite. It is concluded that the MTA version employed in the study may be doped with biomimetic analogs for remineralization of unbonded and bonded artificial caries-like lesions in the presence of SBF.

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“…Remineralization of residual affected dentin can be promoted by the use of bioactive, ionreleasing base materials, e.g., glassionomer or resinbased calciumphosphate cements (RCPC) (Mukai et al, 1998;Dickens et al, 2003Dickens et al, , 2004Exterkate et al, 2005;Ngo et al, 2006). In vitro remineralization experiments with RCPC resulted in significantly increased mineral content, documenting the capacity of RCPC to remineralize and promote healing of mineraldeficient dentin (Dickens et al, 2003;Dickens and Flaim, 2008). A subsequent in vivo proofofprinciple study (Peters et al, 2010) reported increased hardness, evaluated clinically, and increased mineral content, which was determined by elemental analysis of RCPCtreated caries affected dentin.…”

Section: Introductionmentioning

confidence: 99%

In vivo Dentin Microhardness beneath a Calcium-Phosphate Cement

et al. 2010

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A minimally invasive caries-removal technique preserves potentially repairable, caries-affected dentin. Mineral-releasing cements may promote remineralization of soft residual dentin. This study evaluated the in vivo remineralization capacity of resin-based calcium-phosphate cement (Ca-PO4) used for indirect pulp-capping. Permanent carious and sound teeth indicated for extraction were excavated and restored either with or without the Ca-PO4 base (control), followed by adhesive restoration. Study teeth were extracted after 3 months, followed by sectioning and in vitro microhardness analysis of the cavity floor to 115-µm depth. Caries-affected dentin that received acid conditioning prior to Ca-PO4 basing showed significantly increased Knoop hardness near the cavity floor. The non-etched group presented results similar to those of the non-treated group. Acid etching prior to cement application increased microhardness of residual dentin near the interface after 3 months in situ.

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Effect of a bonding agent on in vitro biochemical activities of remineralizing resin-based calcium phosphate cements

Abstract: Compared to the control all treatments resulted in mineral increase. The remineralization was negatively affected by the presence of the bonding agent.

Cited by 33 publications

References 12 publications

Therapeutic effects of novel resin bonding systems containing bioactive glasses on mineral-depleted areas within the bonded-dentine interface

Therapeutic effects of novel resin bonding systems containing bioactive glasses on mineral-depleted areas within the bonded-dentine interface

Remineralization of artificial dentinal caries lesions by biomimetically modified mineral trioxide aggregate

In vivo Dentin Microhardness beneath a Calcium-Phosphate Cement

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