Effect of a 4% titanium tetrafluoride (TiF4) varnish on demineralisation and remineralisation of bovine enamel in vitro

Magalhães, Ana Carolina; Comar, Lívia Picchi; Ríos, Daniela; Delbem, Alberto Carlos Botazzo; Buzalaf, Marília Afonso Rabelo

doi:10.1016/j.jdent.2007.12.001

Cited by 75 publications

(104 citation statements)

References 23 publications

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“…1 Since then, numerous studies demonstrated that TiF 4 is able to reduce carious demineralisation in vitro 2,3 and to prevent the development of carious lesions in situ and in vivo. 4,5 The protective action of TiF 4 is mainly attributed to the formation of a glaze-like surface coating, which is assumed to be composed of titanium oxide 6,7 or of organometallic complexes.…”

Section: Introductionmentioning

confidence: 99%

TiF4 and NaF at pH 1.2 but not at pH 3.5 are able to reduce dentin erosion

Wiegand

Magalhães²,

Sener

et al. 2009

Archives of Oral Biology

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OBJECTIVE: This study aimed to analyse and compare the protective effect of buffered (pH 3.5) and native (pH 1.2) TiF(4) in comparison to NaF solutions of same pH on dentin erosion. DESIGN: Bovine samples were pretreated with 1.50% TiF(4) or 2.02% NaF (both 0.48M F) solutions, each with a pH of 1.2 and 3.5. The control group received no fluoride pretreatment. Ten samples in each group were eroded with HCl (pH 2.6) for 10x60s. Erosion was analysed by determination of calcium release into the acid. Additionally, the surface and the elemental surface composition were examined by scanning electron microscopy (two samples in each group) and X-ray energy-dispersive spectroscopy in fluoridated but not eroded samples (six samples in each group). Cumulative calcium release (nmol/mm(2)) was statistically analysed by repeated measures ANOVA and one-way ANOVA at t=10min. RESULTS: TiF(4) and NaF at pH 1.2 decreased calcium release significantly, while TiF(4) and NaF at pH 3.5 were not effective. Samples treated with TiF(4) at pH 1.2 showed a significant increase of Ti, while NaF pretreatment increased F concentration significantly. TiF(4) at pH 1.2 led to the formation of globular precipitates occluding dentinal tubules, which could not be observed on samples treated with TiF(4) at pH 3.5. NaF at pH 1.2 but not at pH 3.5 induced the formation of surface precipitates covering dentinal tubules. CONCLUSION: Dentin erosion can be significantly reduced by TiF(4) and NaF at pH 1.2, but not at pH 3.5.1 TiF 4 and NaF at pH 1.2 but not at pH 3.5 are able to reduce dentin erosion Objective: This study aimed to analyse and compare the protective effect of buffered (pH 3.5) and native (pH 1.2) TiF 4 in comparison to NaF solutions of same pH on dentin erosion.Design: Bovine samples were pretreated with 1.50% TiF 4 or 2.02% NaF (both 0.48 M F) solutions, each with a pH of 1.2 and 3.5. The control group received no fluoride pretreatment.Ten samples in each group were eroded with HCl (pH 2.6) for 10 x 60s. Erosion was analysed by determination of calcium release into the acid. Additionally, the surface and the elemental surface composition were examined by scanning electron microscopy (two samples in each group) and X-ray energy-dispersive spectroscopy in fluoridated but not eroded samples (six samples in each group). Cumulative calcium release (nmol/mm 2 ) was statistically analysed by repeated measures ANOVA and one-way ANOVA at t = 10 min.Results: TiF 4 and NaF at pH 1.2 decreased calcium release significantly, while TiF 4 and NaF at pH 3.5 were not effective. Samples treated with TiF 4 at pH 1.2 showed a significant increase of Ti, while NaF pretreatment increased F concentration significantly. TiF 4 at pH 1.2 led to the formation of globular precipitates occluding dentinal tubules, which could not be observed on samples treated with TiF 4 at pH 3.5. NaF at pH 1.2 but not at pH 3.5 induced the formation of surface precipitates covering dentinal tubules.Conclusion: Dentin erosion can be significantly reduced by TiF 4 and NaF at p...

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Section: Introductionmentioning

confidence: 99%

TiF4 and NaF at pH 1.2 but not at pH 3.5 are able to reduce dentin erosion

Wiegand

Magalhães²,

Sener

et al. 2009

Archives of Oral Biology

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“…According to previous studies, the low pH of TiF4 (around 1.2), is in favor of the linkage between titanium ions and oxygen of the phosphate group, and results in formation of a titanium dioxide glaze-like layer on the surface. 12,13 In this experiment, laser treatment did not show important effect on reducing demineralization, and groups which were treated with both titanium and laser did not have significant difference with each other. Even in some cases laser reduced the inhibitory effect of TiF4 solution.…”

Section: Discussionmentioning

confidence: 67%

“…14 Magalhães et al demonstrated the effect of TiF4 varnish on decreasing the demineralization and increasing the remineralization of previously sound and carious enamel. 13 In our study, the tetrafluoride solutions were applied approximately at their natural pH (1.2), as it was previously shown that TiF4 is less effective in preventing enamel and dentin erosion when the pH is buffered to a higher value (pH 3.5).…”

Section: Discussionmentioning

confidence: 99%

“…These combinations seem to show the synergistic effect on enhancing enamel resistance. [11][12][13][14] In recent years, the erosion-inhibiting effect of materials containing fluoride compounds has attracted more attention because they were found to be more effective in reducing erosions. The preventive potential of TiF4 against dental demineralization is related to the formation of an acid-resistant surface coating, the increased fluoride uptake and also the titanium incorporation in the hydroxyapatite lattice.…”

Section: 5mentioning

confidence: 99%

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Prevention of Enamel Adjacent to Bracket Demineralization Following Carbon Dioxide Laser Radiation and Titanium Tetra Fluoride Solution Treatment: An In Vitro Study

et al. 2016

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“…No entanto, existem poucos conceitos conclusivos a respeito da prevenção desta alteração dentária (IMFELD, 1996;MAGALHÃES, 2008a;MAGALHÃES, 2008b;RIOS et al, 2008;MAGALHÃES, 2009;WANG et al, 2011).…”

Section: Introductionunclassified

Penetração de materiais resinosos em lesões de erosão, com e sem condicionamento prévio do esmalte: estudo in vitro

Ionta¹

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, agradeço por toda paciência, apoio e atenção não somente durante o mestrado, mas também, durante todo o curso de especialização. Os conhecimentos teóricos e práticos adquiridos foram fundamentais para meu crescimento profissional. Muito obrigada.Ao Prof. Dr. Heitor Marques Honório, pela prontidão na realização da análise estatística e dos fluxogramas desse estudo mesmo em horários imprevistos e também, pela paciência na explicação dos resultados. Marcelo e Gabi, muito obrigada pela grande ajuda durante a fase experimental do estudo. Cat, Pri, Maísa, Gabi, Fer e Paola, nossa convivência foi muito prazerosa e proveitosa, agradeço pelo companheirismo de vocês e por toda contribuição durante meu mestrado. Agradeço a Cat, Gabi e Maísa pela leitura dessa dissertação, apontamentos e sugestões. Ao colega de pós-graduação emÀs colegas de especialização, Cristina, Liliane, Fernanda, Talya e Tatyane, cada uma de vocês trouxe um pouco de seu cotidiano para acrescentar no meu aprendizado. Obrigada pelos momentos gostosos de confraternização e por entenderem minha ausência em alguns momentos devido ao mestrado.À minha dupla, Fernanda, por me ensinar a cada dia uma coisa nova, relacionada à Odontologia ou não, e também pela companhia, ombro amigo e diversos momentos de descontração. Aos funcionários do departamento de Odontopediatria FOB-USP, Lilian,Estela, Dona Lia, Cléo, Lourisvalda, Evandro e Alexandre, obrigada pelo apoio moral, disponibilidade e prontidão em ajudar. A ajuda e o carinho de vocês foram fundamentais nesse processo. Ao departamento de Ciências Biológicas, disciplina de Bioquímica da FOB-USP, através da Prof.ª Dr.ª Marília Affonso Rabello Buzalaf, por permitir a utilização dos equipamentos necessários do laboratório para a realização desse estudo. Aos funcionários do laboratório de Bioquímica da FOB-USP, em especial àLarissa, pela disponibilidade e prontidão em ajudar. À funcionária Márcia do Centro Integrado de Pesquisas da FOB-USP, peladisponibilidade em realizar as leituras dos espécimes no microscópio confocal.Aos funcionários da biblioteca, especialmente ao José Roberto, pelo auxílio e atenção principalmente referente à normativa desse trabalho. Aos funcionários da pós-graduação da FOB-USP, em especial à

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Effect of a 4% titanium tetrafluoride (TiF4) varnish on demineralisation and remineralisation of bovine enamel in vitro

Cited by 75 publications

References 23 publications

TiF4 and NaF at pH 1.2 but not at pH 3.5 are able to reduce dentin erosion

TiF4 and NaF at pH 1.2 but not at pH 3.5 are able to reduce dentin erosion

Prevention of Enamel Adjacent to Bracket Demineralization Following Carbon Dioxide Laser Radiation and Titanium Tetra Fluoride Solution Treatment: An In Vitro Study

Penetração de materiais resinosos em lesões de erosão, com e sem condicionamento prévio do esmalte: estudo in vitro

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