Effect of 900-, 1800-, and 2100-MHz radiofrequency radiation on DNA and oxidative stress in brain

Alkış, Mehmet Eşref; Bilgin, Hakkı Murat; Akpolat, Veysi; Daşdağ, Süleyman; Yeğin, Korkut; Yavaş, Mehmet Cihan; Akdağ, Mehmet

doi:10.1080/15368378.2019.1567526

Cited by 83 publications

(57 citation statements)

References 87 publications

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“…Radiofrequency electromagnetic radiation belongs to the non-ionizing part of the electromagnetic spectrum, as all UV light greater than 100 nm wavelength are too weak to ionize molecules. Permissible RF levels proposed by ICNIRP (1998, 2020) are based on thermal effects only, whereas, a large number of publications suggest non-thermal effects, mainly through free radicals and oxidative stress [61][62][63][64][65][66]. Our work is based on the assumption of cooperative (additive), synergistic, or possible protective mechanisms of successive exposure to RF and UV, since UV radiation is able to induce adverse biological effects, per se.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of Inflammation by Cytokine Production Following Combined Exposure to Ultraviolet and Radiofrequency Radiation of Mobile Phones on 3D Reconstructed Human Skin In Vitro

Szilágyi

Németh

Bakos

et al. 2020

IJERPH

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The absorption of exposure to radiofrequency (RF) emitted by wireless devices leads to a high specific absorption rate in the skin. Ultraviolet (UV) radiation can induce several damages to the skin. The aim of this study was to examine whether combined, consecutive exposure to solar UV radiation and 1950 MHz RF exposure of third generation (3G) mobile system have any effect on inflammation processes in the skin. Under in vitro experiments, the inflammation process was examined by cytokines (IL-1α, IL-6, and IL-8) and MMP-1 enzyme secretion on 3D full thickness human skin model. The RF exposure was applied before or after UV irradiation, in order to study either the possible cooperative or protective effects of exposure to RF and UV. We did not find changes in cytokines due to exposure to RF alone. The RF exposure did not enhance the effects of UV radiation. There was a statistically not-significant decrease in cytokines when the skin tissues were pre-exposed to RF before being exposed to 4 standard erythemal dose (SED) UV compared to UV exposure alone. We found that RF exposure reduced the previously UV-treated MMP-1 enzyme concentration. This study might support the evaluation of the effects on the skin exposed to microwave radiation of 5G mobile technology.

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Section: Discussionmentioning

confidence: 98%

Evaluation of Inflammation by Cytokine Production Following Combined Exposure to Ultraviolet and Radiofrequency Radiation of Mobile Phones on 3D Reconstructed Human Skin In Vitro

Szilágyi

Németh

Bakos

et al. 2020

IJERPH

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“…Owing to the existence of numerous negatively loaded phosphate groups in DNA, Fe and Cu transition metal ions are constantly bound to DNA, and Fe and Cu ions released from proteins in the cell owing to the effect of oxidative stress could also bind to DNA. The binding of Fe and Cu metals to the deoxyribose sugars of DNA transforms the DNA into a target for hydrogen peroxide (H 2 O 2 ), which in turn leads to Haber-Weiss and Fenton reactions generating hydroxyl radicals (OH ) with high reactivity, resulting in significant damage in the cell [14,46]. Also, it has been reported in various studies that electromagnetic fields (EMF) induce the Fenton reaction and free radical activity in the cell [47].…”

Section: Analysis Of Tas Tos Osi 8-ohdg and Mdamentioning

confidence: 99%

“…There are reports that being subjected to cellular phone radiation may lead to infertility and undesired impacts in the reproductive system [6,7] such as single and double strand DNA breaks [8], decrease in sperm concentration and serum testosterone levels [9,10], reduction in sperm vitality and motility [11], increased ROS (reactive oxygen species) [12], decrease in seminiferous tubule diameter and epithelium thickness [13]. It is known that excessive production of ROS and lack of antioxidants in the cells lead to imbalances resulting in molecular oxidative damage, cellular membrane peroxidation, DNA damage and amino acid modifications [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Single-strand DNA breaks and oxidative changes in rat testes exposed to radiofrequency radiation emitted from cellular phones

Alkış

Akdağ

Daşdağ

et al. 2019

Biotechnology & Biotechnological Equipment

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The testes are a sensitive organ to electromagnetic pollution and people are concerned about the harmful effects of the radiofrequency radiation (RFR) emitted from cellular phones. Therefore, the purpose of this study was to investigate the effects of long-term exposure to different RFR frequencies on single-strand DNA breaks and oxidative changes in rat testicular tissue. Twenty-eight male Sprague-Dawley rats were divided randomly into four groups. Three groups were exposed to radiation emitted from 900, 1800 and 2100 MHz RF generators, 2 h/day for 6 months. The sham-control group was kept under the same experimental conditions but the RFR generator was turned off. Immediately after the last exposure, testes were removed and DNA damage, 8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were analyzed. The results of this study indicated that RFR increased TOS, OSI, MDA and 8-OHdG (p < 0.05). TAS levels in the exposed group were lower than in the sham group (p < 0.05). In terms of DNA damage, the tail intensities in the comet assay were higher in the exposure groups (p < 0.05). This study demonstrated that long-term exposure to RFR emitted by cellular phones may cause oxidative stress and oxidative DNA damage in rat testicular tissue and may generate DNA single-strand breaks at high frequencies (1800 and 2100 MHz). Our results showed that some RFR emitted from cellular phones has potential to lead to cell damage in the testes.

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“…No significant change in power spectral densities was observed. The frequency range of the beta wave was in the normal range (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). In our study, eyes were closed 15.33 Hz, eyes were open 19.11 Hz, GSM-EMF group 18.13 Hz, control group (no phone) 20.72 Hz.…”

Section: Resultsmentioning

confidence: 99%

“…In an experimental study on rats, cell phone exposure at different frequencies (900, 1800 and 2100 MHz) was created, and as a result of the study, an increase in oxidative DNA damage in rat brain tissues after the radiation emitted by the cell phones was reported [20]. Fourteen published studies on the effect of GSM mobile phone exposure on brain electrical activity and sleep change have been compiled.…”

Section: Discussionmentioning

confidence: 99%

The effect of short-term electromagnetic fields caused by mobile phones on the electrical activity of alpha and beta brain waves

2020

Ann Clin Anal Med

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Aim: The widespread use of mobile phones by people is increasing in society. The effect of these areas on neurophysiological and EEG is intriguing. In this study, we aimed to investigate the effect of short-term cell phone-induced electromagnetic field on the electrical activity of the EEG alpha and beta bands in the human brain. Materials and Methods: The study was carried on twenty males divided into four groups such as Group 1: eyes closed (10 sec), Group 2: eyes open (10 sec), Group 3: phone exposure (3 min) and Group 4: control group (no phone, 3 min). Results: In our study, no significant change was observed in the EEG electrical activity of the alpha waves between mobile phone use and non-use (p>0.05). As a result of the analysis made for the beta waves, in the comparison between the group exposed to the mobile phone and the non-exposed group, there was a significant difference between the FFT max F and PSD max power parameters (p<0.05), and an insignificant difference between the FFT max value and PSD max F parameters was found (p>0.05). Discussion: The use of mobile phones can lead to some changes in the electrical activity of some bands of the brain.

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Effect of 900-, 1800-, and 2100-MHz radiofrequency radiation on DNA and oxidative stress in brain

Cited by 83 publications

References 87 publications

Evaluation of Inflammation by Cytokine Production Following Combined Exposure to Ultraviolet and Radiofrequency Radiation of Mobile Phones on 3D Reconstructed Human Skin In Vitro

Evaluation of Inflammation by Cytokine Production Following Combined Exposure to Ultraviolet and Radiofrequency Radiation of Mobile Phones on 3D Reconstructed Human Skin In Vitro

Single-strand DNA breaks and oxidative changes in rat testes exposed to radiofrequency radiation emitted from cellular phones

The effect of short-term electromagnetic fields caused by mobile phones on the electrical activity of alpha and beta brain waves

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