2008
DOI: 10.1128/aac.00140-07
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Abstract: The production of interleukin-8 induced by the activation of protease-activated receptor 2 and its synergism with interleukin-1␤ were modulated by 14-membered-ring macrolides, namely, roxithromycin, erythromycin, and clarithromycin, in cultured normal human epidermal keratinocytes. Those macrolides may attenuate the protease-activated receptor 2-interleukin-8 axis and thereby modulate proinflammatory responses in the skin.

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Cited by 8 publications
(7 citation statements)
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“…We have recently shown that 14-membered-ring macrolides, such as ERY and RXM, suppress the IL-1␤-induced production of IL-8 synergized by the activation of PAR2 (32). Interestingly, however, these macrolides do not affect TNF-␣-induced synergism, as shown in this study (Fig.…”
Section: Discussionsupporting
confidence: 66%
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“…We have recently shown that 14-membered-ring macrolides, such as ERY and RXM, suppress the IL-1␤-induced production of IL-8 synergized by the activation of PAR2 (32). Interestingly, however, these macrolides do not affect TNF-␣-induced synergism, as shown in this study (Fig.…”
Section: Discussionsupporting
confidence: 66%
“…The proinflammatory cytokine IL-1 strongly induces the production of IL-8 by NHEK, and the effect of IL-1 is synergized by the stimulation of PAR2 (9,10,32). We show evidence that the activation of PAR2 markedly enhances the production of IL-8 induced by TNF-␣ as well as that induced by IL-1 in NHEK, whereas the stimulation of PAR2 does not potentiate the effect of IFN-␥ (Fig.…”
Section: Discussionmentioning
confidence: 51%
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“…Tetracyclines (most notably doxycycline) have also been documented to have modulatory effects on PAR2 . Macrolides may have a similar modulatory effect . Topical medications commonly used in AD such as glucocorticoids and calcineurin inhibitors have been observed to normalize PAR2 expression…”
Section: Discussion and Clinical Correlationsmentioning
confidence: 99%