Effect of 1-Desamino-8-D-Arginine Vasopressin on Prepulse Inhibition of Startle Supports a Central Etiology of Primary Monosymptomatic Enuresis

Schulz-Juergensen, Sebastian; Rieger, Mareike; Schaefer, Judith; Neusuess, Andrea; Eggert, Paul

doi:10.1016/j.jpeds.2007.05.024

Cited by 27 publications

(22 citation statements)

References 15 publications

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“…SchulzJuergensen et al [13] previously showed that dDAVP strengthens reduced PPI. Our study indicates that children with nmE and reduced PPI probably benefit from dDAVP, not because of a reduction in the volume of urine produced, but rather by improved central reflex control.…”

Section: Discussionmentioning

confidence: 96%

Prepulse inhibition of the startle reflex for differentiation of enuresis in children

Meir

Eggert

2011

Pediatr Nephrol

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Children with enuresis can be classified into those who wet their beds only at night (monosymptomatic enuresis, mE), and those who additionally suffer from daytime symptoms, such as urgency or incontinence (non-monosymptomatic enuresis, nmE). Evidence is growing that enuresis may have a central origin: bedwetting children have lower brainstem reflex control (impaired prepulse inhibition) than normal controls. However, findings on this subject are inconsistent. To date, there has been no study in pediatric patients according to the type of enuresis. With the aim of determining whether mE and nmE children differ in terms of central reflex control, we divided 30 enuretic children into two groups (mE and nmE) based on data recorded in a bladder diary and clinical history (19 with history of diurnal urge, 11 without; age 5-14 years). Prepulse inhibition (PPI) of the startle reflex of the children was measured and compared between groups. A significant difference in PPI was observed between the groups, with the nmE group having a lower median PPI level than the mE group (10 vs. 73%, respectively; p = 0.0002). These findings lead to the assumption that a loss of central control plays a role only in the etiology of nmE. Moreover, they may throw a new light on the classification of enuresis.

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Section: Discussionmentioning

confidence: 96%

Prepulse inhibition of the startle reflex for differentiation of enuresis in children

Meir

Eggert

2011

Pediatr Nephrol

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“…On the contrary, desmopressin may have effects on arousal and central nervous functions as well as the well known antidiuretic properties [35 ]. Maybe its antienuretic properties do not only reside in the reduction of urine output.…”

Section: Sleep-directed and Central Nervous System-directed Treatmentmentioning

confidence: 99%

Diagnosis and management of nocturnal enuresis

Nevéus¹

2009

Current Opinion in Pediatrics

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“…The described association of the number of AVPR1A promoter repeats and PPI [11] and the effect of dDAVP on PPI in nocturnal enuresis [14] therefore strongly suggested genetic variations of the AVPR1a receptor as pathogenetic factors in nocturnal enuresis.…”

Section: Discussionmentioning

confidence: 96%

“…In this context, patients with nocturnal enuresis (NE) represent an interesting group with a specific phenotype: a large proportion has been repeatedly shown to have reduced PPI [12] [13], and show both clinical improvement as well as improvement of PPI through desamino arginine vasopressin (dDAVP) [14], suggesting an effect of dDAVP on central reflex control via the central AVP-receptor AVPR1a.…”

Section: Introductionmentioning

confidence: 99%

No Correlation between <i>AVPR</i>1A Promoter Polymorphisms and Prepulse Inhibition in Patients with Nocturnal Enuresis

Schulz-Juergensen¹,

Bismarck²,

Santer³

et al. 2014

OJNeph

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Effect of 1-Desamino-8-D-Arginine Vasopressin on Prepulse Inhibition of Startle Supports a Central Etiology of Primary Monosymptomatic Enuresis

Cited by 27 publications

References 15 publications

Prepulse inhibition of the startle reflex for differentiation of enuresis in children

Prepulse inhibition of the startle reflex for differentiation of enuresis in children

Diagnosis and management of nocturnal enuresis

No Correlation between <i>AVPR</i>1A Promoter Polymorphisms and Prepulse Inhibition in Patients with Nocturnal Enuresis

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Effect of 1-Desamino-8-D-Arginine Vasopressin on Prepulse Inhibition of Startle Supports a Central Etiology of Primary Monosymptomatic Enuresis

Cited by 27 publications

References 15 publications

Prepulse inhibition of the startle reflex for differentiation of enuresis in children

Prepulse inhibition of the startle reflex for differentiation of enuresis in children

Diagnosis and management of nocturnal enuresis

No Correlation between &lt;i&gt;AVPR&lt;/i&gt;1A Promoter Polymorphisms and Prepulse Inhibition in Patients with Nocturnal Enuresis

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No Correlation between <i>AVPR</i>1A Promoter Polymorphisms and Prepulse Inhibition in Patients with Nocturnal Enuresis