Efeitos da dexmedetomidina sobre a coagulação sangüínea avaliada através do método da tromboelastografia

Martins, César; Tardelli, Maria Ângela; Amaral, José Luiz Gomes do

doi:10.1590/s0034-70942003000600002

Cited by 9 publications

(2 citation statements)

References 20 publications

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“…Dexmedetomidine directly stimulates the α2-adrenoceptor on the surface of the platelet and activates the platelet [ 24 ] ; however, dexmedetomidine also reduces tonic levels of sympathetic outflow and decreases catecholamine release, which indirectly inhibit platelet function. Martins et al [ 25 ] showed that the pro- and antiplatelet effects from the direct and indirect mechanisms resulted in mild hypocoagulation, as shown by TEG analysis with increased R time and decreased coagulation index, which supported our hypothesis that dexmedetomidine could attenuate postoperative hypercoagulability via its sympatholytic effect.…”

Section: Discussionsupporting

confidence: 86%

Effect of dexmedetomidine on blood coagulation in patients undergoing radical gastrectomy under general anesthesia

Chen¹,

Shao²,

Mao³

et al. 2018

Medicine

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Background:Dexmedetomidine can inhibit the perioperative stress response, which plays an important role in postoperative hypercoagulability. This study aimed to investigate whether dexmedetomidine could attenuate the activation of postoperative coagulation.Methods:Patients undergoing open radical gastrectomy under total intravenous anesthesia were randomly allocated to the control group (group Con) and the dexmedetomidine group (group Dex). Dexmedetomidine was intravenously infused at 0.5 μg/kg over 10 minutes before anesthesia induction and then infused at a rate of 0.5 μg/kg/h until peritoneal closure in group Dex, whereas saline was administered in group Con. Blood samples were collected for thrombelastograph (TEG) analysis [reaction time (R time), clot formation time (K time), and clot formation rate (α angle)] and laboratory coagulation testing before dexmedetomidine administration and at the end of surgery.Results:Coagulation was activated after radical gastrectomy, as indicated by TEG analysis and the increased concentrations of plasma fibrin (fibrinogen) degradation product (FDP) and thrombin-antithrombin complex (TAT). The R and K times were significantly prolonged and α angle was significantly decreased in group Dex compared with that in group Con at the end of surgery (P < .05). The concentrations of plasma TAT and FDP in group Dex were significantly lower than those in group Con at the end of surgery (P < .05 or .01).Conclusion:Adjunctive dexmedetomidine with general anesthesia attenuates the activation of coagulation following radical gastrectomy.

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Section: Discussionsupporting

confidence: 86%

Effect of dexmedetomidine on blood coagulation in patients undergoing radical gastrectomy under general anesthesia

Chen¹,

Shao²,

Mao³

et al. 2018

Medicine

View full text Add to dashboard Cite

show abstract

“…Although there are no studies investigating the direct effect of DEX on endothelial injury after SAH, some studies have shown that DEX could exert endothelial protection by activating the endothelial nitric oxide synthase/nitric oxide pathway. 73,74 DEX has also been shown to influence coagulation and fibrinolysis, 75,76 potentially related to the sympatholytic effect that DEX exerts with inhibition of catecholamine release and decrease of sympathetic outflow. That effect plays important roles not only in hypercoagulable states but also in secondary neuronal injury.…”

Section: Dex and Microthrombosismentioning

confidence: 99%

Role of Dexmedetomidine in Aneurysmal Subarachnoid Hemorrhage: A Comprehensive Scoping Review

Liu

Busl

Doré

2020

Journal of Neurosurgical Anesthesiology

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Dexmedetomidine (DEX), an α2-adrenergic agonist, has been widely used for anesthesia, pain control, and intensive care unit sedation. Besides sleep-like sedation, DEX has many other beneficial effects, such as anti-inflammation, antioxidation, and anticell death. Subarachnoid hemorrhage (SAH), a severe and potentially fatal form of stroke, is a complex disease that is divided into 2 phases: early brain injury and delayed cerebral ischemia. In each phase, several pathologic changes are involved, including disturbed intracranial homeostasis, metabolic failure, blood-brain barrier damage, vasospasm, microthrombosis, and cortical spreading depolarization. DEX has been shown to have an effect on these SAH-related pathologic processes. Research shows that DEX could serve as a protective therapy for patients with SAH due to its ability to maintain stable intracerebral homeostasis, balance coagulation-fibrinolysis, repair a damaged blood-brain barrier as well as prevent vasospasm and suppress cortical spreading depolarization by anti-inflammatory, antioxidative, antiapoptotic, and vasoconstriction-dilation effects. In this scoping review, we critically assess the existing data on the potential protective effect of DEX after SAH. So far, only 1 retrospective clinical trial assessing the effect of DEX on clinical outcomes after SAH has been performed. Hence, more trials are still needed as well as translational research bringing results from bench to bedside.

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Effects of dexmedetomidine on blood coagulation: an in vitro study using rotational thromboelastometry

Shin

Boo

2021

J Anesth

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Efeitos da dexmedetomidina sobre a coagulação sangüínea avaliada através do método da tromboelastografia

Cited by 9 publications

References 20 publications

Effect of dexmedetomidine on blood coagulation in patients undergoing radical gastrectomy under general anesthesia

Effect of dexmedetomidine on blood coagulation in patients undergoing radical gastrectomy under general anesthesia

Role of Dexmedetomidine in Aneurysmal Subarachnoid Hemorrhage: A Comprehensive Scoping Review

Effects of dexmedetomidine on blood coagulation: an in vitro study using rotational thromboelastometry

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