2008
DOI: 10.1590/s0102-09352008000300018
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Abstract: RESUMOForam utilizados 25 ratos (Rattus novergicus) submetidos a trauma experimental da medula espinhal, empregando-se aparelho estereotáxico com um peso de 50,5g comprimindo a duramáter durante cinco minutos. Após o trauma, os animais foram divididos em cinco grupos de cinco. O grupo A (controle) recebeu placebo oito horas após o trauma; os grupos B, C, D e E receberam prednisona oito, 24, 48 e 120 horas após o trauma, respectivamente. A prednisona foi administrada na dose inicial de 2mg/kg, durante cinco dia… Show more

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Cited by 5 publications
(9 citation statements)
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References 14 publications
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“…A difference (p=0.0008) was detected among groups for the locomotion capacity. The animals maintained at rest showed less locomotion capacity (10.23±2.12) Attal et al 1990) 0 Absent (distal region of limb -paw -the operated paw is pressed normally on the floor) 1 Discrete (distal region of limb -paw -the paw rests lightly on the floor and the toes are in a ventroflexed position) 2 Discrete to moderate (only the internal edge of the paw is pressed on the floor) 3 Moderate (only the talocalcaneal region -heel -of the paw is pressed on floor; hind paw is in an inverted position) 4 Moderate to intense (the whole distal region -paw -is elevated) 5 Intense (the animal licks the operated paws) Locomotion capacity (according to Silva 2008) 0 Absence of hindlimb movement; non-weight-bearing 1 Subtle movement, disconnected from the hindlimb; non-weight--bearing 2 Visible movement of hindlimb; non-weight-bearing 3 Supports load in hindlimb, but walks with accentuated deficit 4 Walk with moderate difficulty 5 Walk with a discrete deficit, and cannot walk on 7.7 cm wide bar 6 Normal walk or discrete deficit, and can walk on 7.7 cm wide bar 7 Can walk on 6.7 cm wide bar 8 Can walk on 5.7 cm wide bar 9 Can walk on 4.7 cm wide bar 10 Can walk on 3.7 cm wide bar 11 Can walk on 2.7 cm wide bar 12 Can walk on 1.7 cm wide bar than those of the other groups, with mean values and standard deviations of 10.73±1.22 (L), 11.25±0.99 (LE) and 11.37±0.92 (E). In the physical evaluation performed on day 21, only one animal from each group was able to move on the 1.7cm bar.…”
Section: Resultsmentioning
confidence: 99%
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“…A difference (p=0.0008) was detected among groups for the locomotion capacity. The animals maintained at rest showed less locomotion capacity (10.23±2.12) Attal et al 1990) 0 Absent (distal region of limb -paw -the operated paw is pressed normally on the floor) 1 Discrete (distal region of limb -paw -the paw rests lightly on the floor and the toes are in a ventroflexed position) 2 Discrete to moderate (only the internal edge of the paw is pressed on the floor) 3 Moderate (only the talocalcaneal region -heel -of the paw is pressed on floor; hind paw is in an inverted position) 4 Moderate to intense (the whole distal region -paw -is elevated) 5 Intense (the animal licks the operated paws) Locomotion capacity (according to Silva 2008) 0 Absence of hindlimb movement; non-weight-bearing 1 Subtle movement, disconnected from the hindlimb; non-weight--bearing 2 Visible movement of hindlimb; non-weight-bearing 3 Supports load in hindlimb, but walks with accentuated deficit 4 Walk with moderate difficulty 5 Walk with a discrete deficit, and cannot walk on 7.7 cm wide bar 6 Normal walk or discrete deficit, and can walk on 7.7 cm wide bar 7 Can walk on 6.7 cm wide bar 8 Can walk on 5.7 cm wide bar 9 Can walk on 4.7 cm wide bar 10 Can walk on 3.7 cm wide bar 11 Can walk on 2.7 cm wide bar 12 Can walk on 1.7 cm wide bar than those of the other groups, with mean values and standard deviations of 10.73±1.22 (L), 11.25±0.99 (LE) and 11.37±0.92 (E). In the physical evaluation performed on day 21, only one animal from each group was able to move on the 1.7cm bar.…”
Section: Resultsmentioning
confidence: 99%
“…According to Silva (2008), the scale allows for identifying minimum changes that are often imperceptible during deambulation assessment in the open field. The authors used the scale to evaluate the motor capacity of Wistar rats subjected to an experimental spinal cord injury by using 50.5g stereotaxic equipment to apply pressure on the duramater for five minutes.…”
Section: Discussionmentioning
confidence: 99%
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“…Após a realização da tricotomia e em plano anestésico, os ratos foram posicionados em decúbito ventral e feita antissepsia da pele com álcool-iodo-álcool.O acesso à medula espinhal foi realizado pela técnica de laminectomia dorsal em L3, conforme técnica descrita por SILVA et al (2008). Em seguida, nos ratos dos grupos GCS, GCM e GCP, foi realizada a síntese da musculatura epaxial, com padrão de sutura simples contínuo e da pele com Wolff, ambos com fi o de mononailon 4-0.…”
Section: Methodsunclassified
“…Os testes comportamentais foram realizados para avaliar a função neurológica dos animais, e basearam-se no método de escala descritiva adaptada (MEDA) já descrito anteriormente (Silva et al 2008, Torres et al 2010b) e consistiu na observação da capacidade motora (CM) e dos posicionamentos proprioceptivo (PP) e tátil (PT), bem como da permanência em estação no plano inclinado (PI), e da avaliação da sensibilidade dolorosa (SD …”
Section: Quadro 1 Grupos Experimentaisunclassified