Efecto analgésico de la asociación de diclofenaco y vitaminas B1, B6 y B12 en  cirugía de tercera molar.

Cerrate, Víctor Chumpitaz; Huamaní, Juan Sánchez; Chávez-Rimache, Lesly; Rodriguez, Yuri Castro; Flores, Arturo Rodríguez; Quino, César Franco

doi:10.20986/recom.2019.1010/2018

Cited by 1 publication

(5 citation statements)

References 20 publications

(35 reference statements)

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“…These results are similar to those reported by Paiva-Oliveira et al [27], who reported the maximum postoperative pain evaluated using the Visual Box Scale-11 (BS-11) at 6 hours (34 ± 19 mm). Nevertheless, they differ from the study by Chávez et al [8] and Chumpitaz Cerrate et al [13], who reported that the greatest intensity of pain occurred at 24 hours (58.11 ± 14.7 mm and 35.25 ± 22.39 mm respectively). This could be due to the different anti-inflammatory and analgesic rescue therapies employed.…”

Section: Discussioncontrasting

confidence: 94%

“…These results were similar to those reported by Chumpitaz Cerrate et al [13] who found that the combination of diclofenac plus B vitamins (B1, B6, and B12) had a significantly higher analgesic effect at 9 hours, 12 hours and 24 hours postoperatively compared to diclofenac-only therapy. In the same way, Chávez et al [8] reported a significantly higher analgesic effect in the group of dexamethasone plus B vitamins (B1, B6, and B12) compared to the dexamethasone group at 3 hours, 6 hours, 12 hours, 24 hours and 48 hours after mandibular third molar surgery.…”

Section: Discussionsupporting

confidence: 91%

“…In this study, treatment was started preoperatively with meloxicam administered intramuscularly since it is a longacting NSAID; and that it has been shown to be useful in impacted third molar surgery [20,21]. This was followed by a short half-life NSAID such as diclofenac, which has also been shown to be effective in impacted third molar surgery [13]. In addition, diclofenac has presentations alone and is also associated with B vitamins, which makes it easier for the patient to take single tablet every 8 hours.…”

Section: Discussionmentioning

confidence: 99%

“…Recent investigations have reported that vitamins B associated with NSAIDs or corticosteroids have decreased pain after mandibular third molar surgery. This is due to a supra-additive synergistic effect, so lower doses of NSAIDs or corticosteroids could be prescribed (minimizing the risk of adverse drug reactions) [8,13].…”

Section: Discussionmentioning

confidence: 99%

“…The B vitamins when associated with NSAIDs could produce a synergistic effect, enhancing their analgesic and anti-inflammatory effects, reducing adverse effects by requiring lower doses of NSAIDs. However, these beneficial effects have been little studied [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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Synergistic anti-inflammatory effect of NSAIDs plus B vitamins administered pre and postoperatively in third molar surgery: randomized clinical trial

Pérez-Jimenez,

Chumpitaz-Cerrate,

Chávez-Rimache

et al. 2022

Braz. Dent. Sci.

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Objective:The aim of the present study was to evaluate the synergistic anti-inflammatory effect of Non-steroidal anti-inflammatory drugs (NSAIDs) plus B vitamins administered pre and postoperatively in surgeries of impacted mandibular third molars. Material and Methods: Double-blind randomized clinical trial, sixty-six patients participated and were randomized into 2 groups. The control group was administered meloxicam 15 mg intramuscularly plus placebo orally and to the experimental group, meloxicam 15 mg intramuscularly plus vitamins B [B1, B6, and B12] orally; both treatments were administered preoperatively. The anti-inflammatory effect was evaluated by pain intensity, facial swelling (facial contour measurements), and mouth opening (distance between the upper and lower incisors) during the post-surgical phase. Student's t-test was performed for independent samples. Results: In all the evaluated times (1 hour, 6 hours, 12 hours, 24 hours, 2 days, and 3 days after the end of the surgery) the experimental group presented a significantly lower intensity of pain compared to the control group (p<0.05). The highest pain intensity was recorded at 6 hours (17.7 ± 9.1 mm in the experimental group and 34.5 ± 21.3 mm in the control group). Swelling and mouth opening were similar in both groups, at all times evaluated (p>0.05). Conclusion: In the present study, the administration of NSAIDs plus B vitamins (B1, B6, B12) produced lower intensity of pain compared to the administration of only NSAIDs. Nevertheless, swelling and mouth opening were similar in all evaluations for both study groups.

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Section: Discussioncontrasting

confidence: 94%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%