EEG and ERP responses to naloxone and ethanol in monkeys

Are some of the effects of ethanol mediated through NPY?

“…Administration of ethanol alone produced significant dose-related effects on ERP components, as reported previously (Ehlers 1988(Ehlers , 1989Ehlers et al 1991a) and also as seen in Figs 2 and 3. The 0.75 g/kg dose ethanol produced a trend toward an increase in the latency of the N1 (F=3.13; df=1,38; P<0.08) and a significant decrease 138 shown previously to be sensitive to the effects of NPY and ethanol namely the N1 and P3 components.…”

Are some of the effects of ethanol mediated through NPY?

“…Administration of ethanol alone produced significant dose-related effects on ERP components, as reported previously (Ehlers 1988(Ehlers , 1989Ehlers et al 1991a) and also as seen in Figs 2 and 3. The 0.75 g/kg dose ethanol produced a trend toward an increase in the latency of the N1 (F=3.13; df=1,38; P<0.08) and a significant decrease 138 shown previously to be sensitive to the effects of NPY and ethanol namely the N1 and P3 components.…”

Long latency event related potentials in rats: The effects of changes in stimulus parameters and neurochemical lesions

“…Recordings from skull screws placed over frontal cortex contained an early positive wave (P1) as well as a two-peaked negative wave, designated the N1 a and N1 b. These negative waves were found to be in the same latency range as N1 potentials previously recorded from squirrel monkeys and rats using similar passive paradigms (Ehlers, 1988(Ehlers, , 1989Ehlers etal., 1991, a, b, c). These negativities in the 50-100msec range were also found to be sensitive to modifications in the stimulus characteristics used to elicit them.…”

“…These studies have mostly utilized cats (Buchwald and Squires, 1982;Harrison and Buchwald, 1985) and monkeys as subjects (Arthur and Starr, 1984;Neville and Foote, 1984;Glover et al, 1986;Pineda etal., 1987;Ehlers, 1988Ehlers, , 1989. In other studies it has been reported that a P3 could be generated in anaesthetized (O'Brien, 1982) and unanaesthetized rats (Hurlbut et al, 1987;Ehlers et al, 1991, a, b, c).…”

CRF/NPY interactions: A potential role in sleep dysregulation in depression and anxiety

“…The P3 component has been suggested to reflect stimulus evaluation and memory function (see Donchin and Coles, 1988;Verleger, 1988). We have demonstrated that long latency ERPs can be recorded from monkeys (Ehlers, 1988(Ehlers, , 1989 and rats (Ehlers et al, 1991(Ehlers et al, , 1994Ehlers and Chaplin, 1992) when presented auditory stimuli in a similar fashion to those used to elicit ERPs in humans. In rats, this paradigm has been found to produce early negativities (N1s), as well as late positivities in the 250-400 ms range in parietal cortical areas, dorsal hippocampus, and amygdala that are sensitive to stimuli characteristics (Ehlers and Chaplin, 1992) and task (Ehlers et al, 1994).…”

Are some of the effects of ethanol mediated through NPY?

“…Administration of ethanol alone produced significant dose-related effects on ERP components, as reported previously (Ehlers 1988(Ehlers , 1989Ehlers et al 1991a) and also as seen in Figs 2 and 3. The 0.75 g/kg dose ethanol produced a trend toward an increase in the latency of the N1 (F=3.13; df=1,38; P<0.08) and a significant decrease 138 shown previously to be sensitive to the effects of NPY and ethanol namely the N1 and P3 components.…”

Long latency event related potentials in rats: The effects of changes in stimulus parameters and neurochemical lesions

“…Recordings from skull screws placed over frontal cortex contained an early positive wave (P1) as well as a two-peaked negative wave, designated the N1 a and N1 b. These negative waves were found to be in the same latency range as N1 potentials previously recorded from squirrel monkeys and rats using similar passive paradigms (Ehlers, 1988(Ehlers, , 1989Ehlers etal., 1991, a, b, c). These negativities in the 50-100msec range were also found to be sensitive to modifications in the stimulus characteristics used to elicit them.…”

“…These studies have mostly utilized cats (Buchwald and Squires, 1982;Harrison and Buchwald, 1985) and monkeys as subjects (Arthur and Starr, 1984;Neville and Foote, 1984;Glover et al, 1986;Pineda etal., 1987;Ehlers, 1988Ehlers, , 1989. In other studies it has been reported that a P3 could be generated in anaesthetized (O'Brien, 1982) and unanaesthetized rats (Hurlbut et al, 1987;Ehlers et al, 1991, a, b, c).…”

CRF/NPY interactions: A potential role in sleep dysregulation in depression and anxiety

“…The P3 component has been suggested to reflect stimulus evaluation and memory function (see Donchin and Coles, 1988;Verleger, 1988). We have demonstrated that long latency ERPs can be recorded from monkeys (Ehlers, 1988(Ehlers, , 1989 and rats (Ehlers et al, 1991(Ehlers et al, , 1994Ehlers and Chaplin, 1992) when presented auditory stimuli in a similar fashion to those used to elicit ERPs in humans. In rats, this paradigm has been found to produce early negativities (N1s), as well as late positivities in the 250-400 ms range in parietal cortical areas, dorsal hippocampus, and amygdala that are sensitive to stimuli characteristics (Ehlers and Chaplin, 1992) and task (Ehlers et al, 1994).…”

Are some of the effects of ethanol mediated through NPY?

“…Administration of ethanol alone produced significant dose-related effects on ERP components, as reported previously (Ehlers 1988(Ehlers , 1989Ehlers et al 1991a) and also as seen in Figs 2 and 3. The 0.75 g/kg dose ethanol produced a trend toward an increase in the latency of the N1 (F=3.13; df=1,38; P<0.08) and a significant decrease 138 shown previously to be sensitive to the effects of NPY and ethanol namely the N1 and P3 components.…”

Long latency event related potentials in rats: The effects of changes in stimulus parameters and neurochemical lesions

“…Recordings from skull screws placed over frontal cortex contained an early positive wave (P1) as well as a two-peaked negative wave, designated the N1 a and N1 b. These negative waves were found to be in the same latency range as N1 potentials previously recorded from squirrel monkeys and rats using similar passive paradigms (Ehlers, 1988(Ehlers, , 1989Ehlers etal., 1991, a, b, c). These negativities in the 50-100msec range were also found to be sensitive to modifications in the stimulus characteristics used to elicit them.…”

“…These studies have mostly utilized cats (Buchwald and Squires, 1982;Harrison and Buchwald, 1985) and monkeys as subjects (Arthur and Starr, 1984;Neville and Foote, 1984;Glover et al, 1986;Pineda etal., 1987;Ehlers, 1988Ehlers, , 1989. In other studies it has been reported that a P3 could be generated in anaesthetized (O'Brien, 1982) and unanaesthetized rats (Hurlbut et al, 1987;Ehlers et al, 1991, a, b, c).…”

CRF/NPY interactions: A potential role in sleep dysregulation in depression and anxiety

“…The P3 component has been suggested to reflect stimulus evaluation and memory function (see Donchin and Coles, 1988;Verleger, 1988). We have demonstrated that long latency ERPs can be recorded from monkeys (Ehlers, 1988(Ehlers, , 1989 and rats (Ehlers et al, 1991(Ehlers et al, , 1994Ehlers and Chaplin, 1992) when presented auditory stimuli in a similar fashion to those used to elicit ERPs in humans. In rats, this paradigm has been found to produce early negativities (N1s), as well as late positivities in the 250-400 ms range in parietal cortical areas, dorsal hippocampus, and amygdala that are sensitive to stimuli characteristics (Ehlers and Chaplin, 1992) and task (Ehlers et al, 1994).…”