EEG activities in the orbitofrontal cortex and dorsolateral prefrontal cortex during the development of morphine dependence, tolerance and withdrawal in rhesus monkeys

Liu, Ning; Liu, Yancheng; Yang, Fan; Yu, Hualin; Wilson, Fraser A.W.; Ma, Yuanye; Hu, Xintian

doi:10.1016/j.brainres.2005.06.037

Cited by 21 publications

(21 citation statements)

References 28 publications

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“…We chose to escalate the morphine doses according to a previous study in our laboratory (Liu et al 2005) and other references (Listos et al 2008). Our previous study showed that morphine injection with increasing doses (0.5, 1.6, 5.0 and 8.0 mg/kg, for 10 days) changed the electroencephalogram recorded in the orbitofrontal cortex and dorsolateral prefrontal cortex (DLPFC) in rhesus monkeys (Liu et al 2005). In the current experiment, we used lower Morphine on monkey memory 543 doses of morphine (1.5, 3.0 and 4.5 mg/kg) in order to prevent the monkeys from long-lasting physiological effects.…”

Section: Discussionmentioning

confidence: 99%

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Effect of morphine on conditioned place preference in rhesus monkeys

Wang

et al. 2011

Addiction Biology

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ABSTRACTa db_289 539..546In rodents, a conditioned place preference (CPP) can be induced by morphine. In the current study, we designed a biased place conditioning paradigm to test the rewarding effects of morphine in freely moving rhesus monkeys. Five monkeys were first placed in three serial rooms with the doors open between them for three days. After this habituation period, during which baseline preference for each of the two end rooms was measured, CPP conditioning occurred when the monkeys were injected intramuscularly with morphine at an increasing dose (1.5, 3, 4.5 mg/kg) before they entered the non-preferred room and on alternate days, with saline before they entered the preferred room. Morphine and saline treatment lasted for six days, respectively. CPP was tested 24 hours after the end of CPP training. The result showed that in all five monkeys, CPP was induced by the morphine treatment. The preference lasted for at least 15.3 Ϯ 1.7 months.

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Section: Discussionmentioning

confidence: 99%

“…with 1.5 mg/kg morphine (Liu et al 2005). The dose was then increased to 3 and 4.5 mg/kg on the following alternate days (D3, D5, D7, D9, D11).…”

Section: Cpp Conditioningmentioning

confidence: 99%

Effect of morphine on conditioned place preference in rhesus monkeys

Wang

et al. 2011

Addiction Biology

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“…OFC neurons have been shown to flexibly encode representations of stimulus-outcome and action-outcome associations (Schoenbaum et al, 1998;Tremblay and Schultz, 1999;Wallis and Miller, 2003;Padoa-Schioppa and Assad, 2006;van Duuren et al, 2008van Duuren et al, , 2009. Although gamma oscillatory activity has been reported previously for human, monkey, and rat OFC (Nishida et al, 2004;Liu et al, 2005;Sun et al, 2006), the question arises whether gamma oscillations exert similar functions in emotional decision-making and valuation as suggested by studies on sensory processing.…”

Section: Introductionmentioning

confidence: 97%

Learning-Associated Gamma-Band Phase-Locking of Action–Outcome Selective Neurons in Orbitofrontal Cortex

Wingerden¹,

Vinck²,

Lankelma³

et al. 2010

J. Neurosci.

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Gamma oscillations (30 -100 Hz) correlate to a variety of neural functions, including sensory processing, attention, and action selection. However, they have barely been studied in relation to emotional processing and valuation of sensory signals and actions. We conducted multineuron and local field potential recordings in the orbitofrontal cortex (OFC) of rats performing a task in which they made go or no-go decisions based on two olfactory stimuli predicting appetitive or aversive outcomes.Gamma power was strongest during the late phase of odor sampling, just before go/no-go movement, and increased with behavioral learning. Learning speed was correlated to the slope of the gamma power increment. Spikes of OFC neurons were consistently timed to the gamma rhythm during odor sampling, regardless of the associated outcome. However, only a specific subgroup of cells showed consistent phase timing. These cells showed action-outcome selective activity, not during stimulus sampling but during subsequent movement responses. During sampling, this subgroup displayed a suppression in firing rate but a concurrent increment in the consistency of spike timing relative to gamma oscillations.In addition to gamma rhythm, OFC field potentials were characterized by theta oscillations during odor sampling. Neurons phaselocked to either theta or gamma rhythms but not to both, suggesting that they become associated with separate rhythmic networks involving OFC. Altogether, these results suggest that OFC gamma-band synchronization reflects inhibitory control over a subpopulation of neurons that express information about the emotional valence of actions after a motor decision, which suggests a novel mechanism for response inhibition.

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“…Using custom built equipment [6,18,19], EEG recordings were collected in a sound-attenuating chamber (40 cm× 25 cm), which was illuminated by a 12 V bulb. All electrodes on the rat were connected by a cable to an amplifier and then to a computer.…”

Section: Eeg Recordingsmentioning

confidence: 99%

“…In addition, because of pronounced interindividual differences, the normalized power was adopted and calculated as (P 1 −P 0 )/P 0 ×100%, where P 0 denotes the power for baseline recordings and P 1 denotes the power for post-drug recordings. We have previously shown that normalized power is a reliable parameter, even when the baseline EEG is not stable [6,18,19].…”

Section: Data Analyses and Statisticsmentioning

confidence: 99%

Differential effects of aging on EEG after baclofen administration

Cui

2011

Sci. China Life Sci.

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Baclofen is a selective gamma-aminobutyric acid (GABA) type B agonist that may have important medicinal uses, such as in analgesics and drug addiction treatment. In addition, evidence is accumulating that suggests GABAergic-mediated neurotransmission is altered during aging. This study investigated whether baclofen administration (5 mg kg −1 ) induces differential effects on cortical electrical activity with age. Electroencephalograms (EEGs) were recorded from young (3-4 months) and aged (15-17 months) rats, and both the absolute and relative powers in five frequency bands (delta: 2-4 Hz; theta: 4-8 Hz; alpha: 8-12 Hz; beta: 12-20 Hz; gamma: 20-100 Hz) were analyzed. Before administration of baclofen, we found that the EEG relative power in the beta band was higher in the aged than that in the young rats. After administration of baclofen, there was a slower increase in the relative power in the delta band in the aged than that in the young rats. Moreover, there was no significant difference between the two age groups in absolute power in any frequency band. These findings indicate that baclofen treatment appears to differentially modify cortical EEG activity as a function of age. Our data further elucidate the relationship between GABA B receptor-mediated neurotransmission and aging.aging, baclofen, EEG, spectra power, rat Citation:

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EEG activities in the orbitofrontal cortex and dorsolateral prefrontal cortex during the development of morphine dependence, tolerance and withdrawal in rhesus monkeys

Cited by 21 publications

References 28 publications

Effect of morphine on conditioned place preference in rhesus monkeys

Effect of morphine on conditioned place preference in rhesus monkeys

Learning-Associated Gamma-Band Phase-Locking of Action–Outcome Selective Neurons in Orbitofrontal Cortex

Differential effects of aging on EEG after baclofen administration

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