Editorial: The Role of Calcium Handling in Heart Failure and Heart Failure Associated Arrhythmias

Johnson, Dan; Mugelli, Alessandro; Cerbai, Elisabetta

doi:10.3389/fphys.2019.00001

Cited by 103 publications

(161 citation statements)

References 7 publications

Supporting

Mentioning

156

Contrasting

Order By: Relevance

“…Relatively few dynamic brain PET/MRI studies have investigated the effects of MRAC methods on accuracy and precision using kinetic analysis for quantification of outcome parameters [ 36 , 39 , 43 , 45 , 46 ]. Schramm et al [ 36 ] evaluated ZTE-MRAC and Atlas-MRAC compared to CT-based AC in eight healthy volunteers using a SIGNA PET/MRI scanner and [ 18 F]PE2I.…”

Section: Discussionmentioning

confidence: 99%

“…Like CT-AC, most of the reported MRAC methods disregarded possible heterogeneity in tissue by using AC maps with fixed values assigned to a limited number of tissue types. More detailed attenuation maps may be developed by optimizing the simultaneous acquired information from MRI and PET combined with templates/atlas and machine learning [ 39 , 40 , 42 , 45 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Accuracy and precision of zero-echo-time, single- and multi-atlas attenuation correction for dynamic [11C]PE2I PET-MR brain imaging

et al. 2020

View full text Add to dashboard Cite

Background A valid photon attenuation correction (AC) method is instrumental for obtaining quantitatively correct PET images. Integrated PET/MR systems provide no direct information on attenuation, and novel methods for MR-based AC (MRAC) are still under investigation. Evaluations of various AC methods have mainly focused on static brain PET acquisitions. In this study, we determined the validity of three MRAC methods in a dynamic PET/MR study of the brain. Methods Nine participants underwent dynamic brain PET/MR scanning using the dopamine transporter radioligand [11C]PE2I. Three MRAC methods were evaluated: single-atlas (Atlas), multi-atlas (MaxProb) and zero-echo-time (ZTE). The 68Ge-transmission data from a previous stand-alone PET scan was used as reference method. Parametric relative delivery (R1) images and binding potential (BPND) maps were generated using cerebellar grey matter as reference region. Evaluation was based on bias in MRAC maps, accuracy and precision of [11C]PE2I BPND and R1 estimates, and [11C]PE2I time-activity curves. BPND was examined for striatal regions and R1 in clusters of regions across the brain. Results For BPND, ZTE-MRAC showed the highest accuracy (bias < 2%) in striatal regions. Atlas-MRAC exhibited a significant bias in caudate nucleus (− 12%) while MaxProb-MRAC revealed a substantial, non-significant bias in the putamen (9%). R1 estimates had a marginal bias for all MRAC methods (− 1.0–3.2%). MaxProb-MRAC showed the largest intersubject variability for both R1 and BPND. Standardized uptake values (SUV) of striatal regions displayed the strongest average bias for ZTE-MRAC (~ 10%), although constant over time and with the smallest intersubject variability. Atlas-MRAC had highest variation in bias over time (+10 to − 10%), followed by MaxProb-MRAC (+5 to − 5%), but MaxProb showed the lowest mean bias. For the cerebellum, MaxProb-MRAC showed the highest variability while bias was constant over time for Atlas- and ZTE-MRAC. Conclusions Both Maxprob- and ZTE-MRAC performed better than Atlas-MRAC when using a 68Ge transmission scan as reference method. Overall, ZTE-MRAC showed the highest precision and accuracy in outcome parameters of dynamic [11C]PE2I PET analysis with use of kinetic modelling.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Accuracy and precision of zero-echo-time, single- and multi-atlas attenuation correction for dynamic [11C]PE2I PET-MR brain imaging

et al. 2020

View full text Add to dashboard Cite

show abstract

“…This enzyme, which removes α-(1–6) linkages, detaches from glycogen units of glucose and is important for continued glycogen breakdown during insect flight [ 45 ]. Alpha-glucosidase catalyzes the hydrolysis of α-glucosidic bonds, releasing free glucose; this enzyme is present as a soluble form in the midgut lumen or bound to cell membranes and is important for the digestion of sucrose [ 46 , 47 ]. Trehalase is the enzyme that hydrolyses trehalose, a circulating disaccharide containing two D-glucose units in an α,α-(1-1) linkage, which plays a crucial role as a metabolic source of energy [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Essential (Mg, Fe, Zn and Cu) and Non-Essential (Cd and Pb) Elements in Predatory Insects (Vespa crabro and Vespa velutina): A Molecular Perspective

Andreani

Ferlizza

Cabbri

et al. 2020

IJMS

View full text Add to dashboard Cite

The recent introduction of the Asian yellow-legged hornet, Vespa velutina, into Europe has raised concern regarding the threat to honeybees and the competition with the European hornet, Vespa crabro. The aim of this study was to investigated essential (Mg, Fe, Zn, Cu) and non-essential (Cd and Pb) elements in these two species. Element concentrations were determined in the whole body and separately in the head, thorax and abdomen using atomic absorption spectrometry (AAS). The changes in essential element concentration and speciation during metamorphosis were also studied using size exclusion chromatography followed by AAS and proteomic analysis. In both species, the essential elements were more concentrated in the abdomen due to the presence of fat bodies. Magnesium, Fe and Zn concentrations were significantly higher in V. crabro than in V. velutina and could have been related to the higher aerobic energy demand of the former species required to sustain foraging flight. Low concentrations of Cd and Pb were indicative of low environmental exposure. The concentration and speciation of essential elements, particularly Fe, varied among the developmental stages, indicating a modification of ligand preferences during metamorphosis. Overall, the results in the present study provide a better understanding of the hornet metal metabolism and a foundation for additional studies.

show abstract

“…The authors, at first, demonstrated that there were no differences in running economy between a control and stiff shoe; however, once they split up their runners into responders and non-responders, the responders showed an average improvement in running economy of 2.9% when running in the stiff shoe condition. A 2.9% improvement in running economy would correspond to a performance improvement of 1.93% 40 or 2.26% 41 , which on a 2-h. marathon would correspond to a decrease in running time of ~ 139 or ~ 163 s. Stefanyshyn and Fusco 10 showed group improvements in sprinting performance (i.e., in absolute time) of ~ 0.47% when the stiffness of sprinting spikes was increased by inserting straight carbon fibre plates with a stiffness of 47 N·mm −1 in athletes’ own footwear. More importantly, however, the athletes had their individual best performance in different stiffness conditions.…”

Section: Discussionmentioning

confidence: 99%

Increasing the midsole bending stiffness of shoes alters gastrocnemius medialis muscle function during running

Čigoja

Fletcher

Esposito

et al. 2021

Sci Rep

View full text Add to dashboard Cite

In recent years, increasing the midsole bending stiffness (MBS) of running shoes by embedding carbon fibre plates in the midsole resulted in many world records set during long-distance running competitions. Although several theories were introduced to unravel the mechanisms behind these performance benefits, no definitive explanation was provided so far. This study aimed to investigate how the function of the gastrocnemius medialis (GM) muscle and Achilles tendon is altered when running in shoes with increased MBS. Here, we provide the first direct evidence that the amount and velocity of GM muscle fascicle shortening is reduced when running with increased MBS. Compared to control, running in the stiffest condition at 90% of speed at lactate threshold resulted in less muscle fascicle shortening (p = 0.006, d = 0.87), slower average shortening velocity (p = 0.002, d = 0.93) and greater estimated Achilles tendon energy return (p ≤ 0.001, d = 0.96), without a significant change in GM fascicle work (p = 0.335, d = 0.40) or GM energy cost (p = 0.569, d = 0.30). The findings of this study suggest that running in stiff shoes allows the ankle plantarflexor muscle–tendon unit to continue to operate on a more favourable position of the muscle’s force–length–velocity relationship by lowering muscle shortening velocity and increasing tendon energy return.

show abstract

Editorial: The Role of Calcium Handling in Heart Failure and Heart Failure Associated Arrhythmias

Cited by 103 publications

References 7 publications

Accuracy and precision of zero-echo-time, single- and multi-atlas attenuation correction for dynamic [11C]PE2I PET-MR brain imaging

Accuracy and precision of zero-echo-time, single- and multi-atlas attenuation correction for dynamic [11C]PE2I PET-MR brain imaging

Essential (Mg, Fe, Zn and Cu) and Non-Essential (Cd and Pb) Elements in Predatory Insects (Vespa crabro and Vespa velutina): A Molecular Perspective

Increasing the midsole bending stiffness of shoes alters gastrocnemius medialis muscle function during running

Contact Info

Product

Resources

About