Editorial: missed opportunities to detect colorectal cancer in inflammatory bowel disease—getting to the root. Authors’ reply

Chee, Desmond; Kennedy, Nicholas A.; Goodhand, James; Ahmad, Tariq

doi:10.1111/apt.16215

Aliment Pharmacol Ther

2020

DOI: 10.1111/apt.16215

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Editorial: missed opportunities to detect colorectal cancer in inflammatory bowel disease—getting to the root. Authors’ reply

Desmond Chee

Nicholas A. Kennedy

James Goodhand

et al.

Abstract: LINKED CONTENT This article is linked to Gordon et al and Mahmoud & Itzkowitz papers. To view these articles, visit https://doi.org/10.1111/apt.16155 and https://doi.org/10.1111/apt.16175

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Bifidobacterium infantis Promotes Foxp3 Expression in Colon Cells via PD-L1-Mediated Inhibition of the PI3K-Akt-mTOR Signaling Pathway

Zhou

Xie²,

Li³

2022

Front. Immunol.

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AimOur objective was to investigate whether Bifidobacterium infantis inhibits PI3K-Akt-mTOR signaling and upregulates Foxp3 expression through PD-L1 and to explore the possible mechanism of action of B. infantis in cellular immunosuppression. MethodThe effects of B. infantis supernatant on PD-L1, PD-1, Foxp3, and the PI3K-Akt-mTOR signaling pathway were observed by culturing HCT-116 cells. Simultaneously, the effects of blocking PD-L1 on PD-1, on Foxp3 protein and mRNA, and on the PI3K-Akt-mTOR signaling pathway protein were observed.ResultsB. infantis supernatant was able to upregulate the protein and mRNA expression of PD-L1 and Foxp3 and downregulate the phosphorylated protein expression of PI3K, Akt, and mTOR (P < 0.05); however, for PI3K, Akt, and mTOR, there was no change in the total protein expression. After the blocking of PD-L1, the stimulatory effect of B. infantis supernatant on Foxp3 and the inhibitory effect on the phosphorylated protein expression of PI3K, Akt, and mTOR were weakened.ConclusionB. infantis may inhibit the PI3K-Akt-mTOR signaling pathway and promote the expression of Foxp3 through PD-L1, which may be a target via which B. infantis exerts its immunosuppressive effect.

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Bifidobacterium infantis Promotes Foxp3 Expression in Colon Cells via PD-L1-Mediated Inhibition of the PI3K-Akt-mTOR Signaling Pathway

Zhou

Xie²,

Li³

2022

Front. Immunol.

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Editorial: missed opportunities to detect colorectal cancer in inflammatory bowel disease—getting to the root. Authors’ reply

Abstract: LINKED CONTENT This article is linked to Gordon et al and Mahmoud & Itzkowitz papers. To view these articles, visit https://doi.org/10.1111/apt.16155 and https://doi.org/10.1111/apt.16175

Cited by 1 publication

References 6 publications

Bifidobacterium infantis Promotes Foxp3 Expression in Colon Cells via PD-L1-Mediated Inhibition of the PI3K-Akt-mTOR Signaling Pathway

Bifidobacterium infantis Promotes Foxp3 Expression in Colon Cells via PD-L1-Mediated Inhibition of the PI3K-Akt-mTOR Signaling Pathway

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