Editorial for the Special Issue on Micro/Nanofluidic Devices for Single Cell Analysis, Volume II

Santra, Tuhin Subhra; Tseng, Fan‐Gang

doi:10.3390/mi12080875

Micromachines

2021

DOI: 10.3390/mi12080875

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Editorial for the Special Issue on Micro/Nanofluidic Devices for Single Cell Analysis, Volume II

Tuhin Subhra Santra

Fan‐Gang Tseng

Abstract: The functional, genetic, or compositional heterogeneity of healthy and diseased tissues promotes significant challenges to drug discovery and development [...]

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2022

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Cited by 2 publications

References 32 publications

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Microfluidic mechanoporation for cellular delivery and analysis

Chakrabarty

Gupta

Illath

et al. 2022

Materials Today Bio

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Highly efficient intracellular delivery strategies are essential for developing therapeutic, diagnostic, biological, and various biomedical applications. The recent advancement of micro/nanotechnology has focused numerous researches towards developing microfluidic device-based strategies due to the associated high throughput delivery, cost-effectiveness, robustness, and biocompatible nature. The delivery strategies can be carrier-mediated or membrane disruption-based, where membrane disruption methods find popularity due to reduced toxicity, enhanced delivery efficiency, and cell viability. Among all of the membrane disruption techniques, the mechanoporation strategies are advantageous because of no external energy source required for membrane deformation, thereby achieving high delivery efficiencies and increased cell viability into different cell types with negligible toxicity. The past two decades have consequently seen a tremendous boost in mechanoporation-based research for intracellular delivery and cellular analysis. This article provides a brief review of the most recent developments on microfluidic-based mechanoporation strategies such as microinjection, nanoneedle arrays, cell-squeezing, and hydroporation techniques with their working principle, device fabrication, cellular delivery, and analysis. Moreover, a brief discussion of the different mechanoporation strategies integrated with other delivery methods has also been provided. Finally, the advantages, limitations, and future prospects of this technique are discussed compared to other intracellular delivery techniques.

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Microfluidic mechanoporation for cellular delivery and analysis

Chakrabarty

Gupta

Illath

et al. 2022

Materials Today Bio

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Single-Cell Analysis 2.0

Santra

Tseng

2022

Cells

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Editorial for the Special Issue on Micro/Nanofluidic Devices for Single Cell Analysis, Volume II

Abstract: The functional, genetic, or compositional heterogeneity of healthy and diseased tissues promotes significant challenges to drug discovery and development [...]

Cited by 2 publications

References 32 publications

Microfluidic mechanoporation for cellular delivery and analysis

Microfluidic mechanoporation for cellular delivery and analysis

Single-Cell Analysis 2.0

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