Editorial Comment from Dr Shiota to Magnetic resonance imaging/transrectal ultrasonography fusion targeted prostate biopsy finds more significant prostate cancer in biopsy‐naïve Japanese men compared with the standard biopsy

Shiota, Masaki

doi:10.1111/iju.14156

Cited by 1 publication

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 Recently, there is increasing evidence for MRI-TBx's usefulness as a diagnostic tool for PC in biopsy-naive men. 6,7 The PRECISION trial compared MRI-TBx alone versus SBx and found a 3% of csPC missed by performing MRI-TBx without SBx. 8 However, in other studies, this rate was twice as higher.…”

Section: Introductionmentioning

confidence: 99%

Fusion‐targeted biopsy significantly improves prostate cancer detection in biopsy‐naïve men

et al. 2023

Self Cite

View full text Add to dashboard Cite

Objective The precise diagnosis of prostate cancer (PC) is crucial to avoid underdiagnosis, overdiagnosis, and overtreatment. We aimed to compare clinically significant PC (csPC) detection between MRI/ultrasound fusion‐targeted prostate (TBx) compared to systematic biopsy (SBx) in biopsy‐naïve Japanese men. Methods We included patients with suspect PC due to elevated PSA level or abnormal digital rectal examination, or both. csPC was defined as International Society Urological Pathology (ISUP) grade group ≥2 (csPC‐A) and ISUP grade group ≥3 (csPC‐B). Results This study included 143 patients. Overall PC detection was 66.4% for SBx and 67.8% for MRI‐TBx. MRI‐TBx presented a significantly higher rate of csPC detection (csPC‐A 67.1% vs. 58.7%, p = 0.04, and csPC‐B 49.6% vs. 39.9%, p < 0.001) and significantly lower detection of non‐csPC‐A (0.6% vs. 6.7%). Importantly, MRI‐TBx missed 4.9% (7/143) of csPC‐A and only 0.7% (1/143) of csPC‐B. On the other hand, SBx alone missed 13.3% (19/143) of csPC‐A and 4.2% (6/143) of csPC‐B. Conclusion MRI‐TBx significantly outperformed 12‐cores SBx for csPC detection and decreased non‐csPC detection in biopsy‐naive men. Performing MRI‐TBx without SBx would have missed some csPC, supporting that MRI‐TBx synergizes with SBx to increase csPC detection.

show abstract

Section: Introductionmentioning

confidence: 99%