Editing Streptomyces genome using target AID system fused with UGI‐degradation tag
Pamella Apriliana,
Prihardi Kahar,
Norimasa Kashiwagi
et al.
Abstract:The utilization of Streptomyces as a microbial chassis for developing innovative drugs and medicinal compounds showcases its capability to produce bioactive natural substances. Recent focus on the clustered regularly interspaced short palindromic repeat (CRISPR) technology highlights its potential in genome editing. However, applying CRISPR technology in certain microbial strains, particularly Streptomyces, encounters specific challenges. These challenges include achieving efficient gene expression and maintai… Show more
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