Eczematous and Pigmentary Lichenoid Dermatitis

Wilson, Donald

doi:10.1001/archderm.1946.01510390002001

Cited by 29 publications

(5 citation statements)

References 3 publications

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“…associated with a hyperplastic granular layer leads most probably to a diagnosis of ILP. Contrary to many other types of drug eruptions, it has to be noted that eosinophils are seen infrequently in LDE ( [10][11][12] and our study), whilst they are absent in ILP.…”

Section: Discussioncontrasting

confidence: 64%

Histopathological Discriminant Criteria between Lichenoid Drug Eruption and Idiopathic Lichen planus: Retrospective Study on Selected Samples

Haute¹,

Antoine²,

Lachapelle³

1989

Dermatology

122

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The lesions observed in 15 idiopathic lichen planus (ILP) skin biopsies were compared with those occurring in 15 clinically relevant lichenoid drug eruptions (LDE). Various histopathological features were taken into account. Statistical analysis of results showed that none of these can be considered as a significant criterium allowing a pathognomonic differential diagnosis between ILP and LDE. Nevertheless, a strong suggestion of drug etiology can be inferred when the following histopathological signs (‘LDE-related criteria’) are present: focal parakeratosis, focal interruption of the granular layer, cytoid bodies in the cornified and granular layers, present in more than 50% of LDE and never in ILP

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Section: Discussioncontrasting

confidence: 64%

Histopathological Discriminant Criteria between Lichenoid Drug Eruption and Idiopathic Lichen planus: Retrospective Study on Selected Samples

Haute¹,

Antoine²,

Lachapelle³

1989

Dermatology

122

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“…The association of the skin condition with cerebral symptoms has not previously been described, and the nail dystrophy, which was such a pronounced feature, has not received much attention. Pigmentation (Lutterloh and Shallenberger, 1946) and loss of nails (Wilson, 1946) have been mentioned as occurring, while it is known by fluorescence under Wood's light that mepacrine is excreted in the nails (Kierland et al, 1946). In the present case the Beau line of the nail corresponds in date with the first acute appearance of the eruption three months before.…”

Section: Case Reportsupporting

confidence: 47%

A Case of Mepacrine Dermatitis

Clarke¹

1949

BMJ

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“…Gold may produce generalized eczema or exfoliative dermatitis after many months of therapy for rheumatoid arthritis, necessitating withdrawal of the drug. Antimalarial prophylaxis was recognized during World War II as being capable of inducing eczema and lichen planus in many soldiers (Wilson 1946). Our first case developed eczematous changes initially but these gradually merged into a more obvious lichen planus-like eruption.…”

Section: Discussionmentioning

confidence: 99%