Ectopic ACTH Secretion Secondary to Metastatic Acinic Cell Carcinoma of the Parotid Gland: A Case Report and Review of Current Evidence for Systemic Therapy

Wade, Louise; Kitching, Paul; Winton, E. De

doi:10.1177/2324709620918080

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…After craniocerebral injury, the humoral changes mainly include increased release of antidiuretic hormone, activation of the sympathetic adrenal system, and altered secretion of hypothalamic hormone [25]. e destruction of the blood-CSF barrier can increase the secretion of pituitary hormone ACTH and promote the adrenal expression and release of COR through the hypothalamic-pituitary-adrenal regulatory axis, which can improve the body's antistress [26]. In this process, the body can protect itself.…”

Section: Discussionmentioning

confidence: 99%

Change of Levels of NGF, ACTH, and AVP in the Cerebrospinal Fluid after Decompressive Craniectomy of Craniocerebral Injury and Their Relationship with Communicating Hydrocephalus

Wang¹,

Fan²,

Zhao³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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In recent years, the incidence of craniocerebral trauma has increased, making it one of the important causes of death and disability in neurosurgery patients. The decompressive craniectomy (DC) after severe craniocerebral injury has become the preferred treatment for patients with severe craniocerebral injury, but the incidence of postoperative hydrocephalus has become a difficult problem in clinical treatment. This study observed the changes of nerve growth factor (NGF), adrenocorticotropic hormone (ACTH), and arginine vasopressin (AVP) levels in the CSF after DC in patients with craniocerebral injury and analyzed the relationship between the three indicators and communicating hydrocephalus. The results showed that the levels of NGF, ACTH, and AVP in patients with cranial injury after DC were significantly higher than those in healthy subjects, and subdural effusion, traumatic subarachnoid hemorrhage (tSAH), and the levels of NGF, ACTH, and AVP in the CSF were independent risk factors for communicating hydrocephalus. Monitoring the levels of NGF, ACTH, and AVP is of great significance for clinicians to judge the occurrence of traffic hydrocephalus, evaluate the prognosis of patients with craniocerebral injury after DC, and guide clinical treatment.

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Section: Discussionmentioning

confidence: 99%

Change of Levels of NGF, ACTH, and AVP in the Cerebrospinal Fluid after Decompressive Craniectomy of Craniocerebral Injury and Their Relationship with Communicating Hydrocephalus

Wang¹,

Fan²,

Zhao³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…There is only one case of a primary acinic cell carcinoma secreting ACTH (Castro Oliveira et al 2019). In cases where long-term follow-up has been performed, patients suffered from disease complications and died despite being treated with chemotherapy and/or radiation therapy (Shenoy et al 2011;Dacruz et al 2016;Castro Oliveira et al 2019;Wade et al 2020;Burch et al 2021).…”

Section: Discussionmentioning

confidence: 99%

ACTH-secreting parotid acinic cell carcinoma unusually reported as a paraneoplastic syndrome

Amoateng

Hasbani

Vera

et al. 2022

Endocrine Regulations

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Paraneoplastic syndromes, induced by an immunological cross-reaction or hormone/peptide secretion, are an atypical presentation of tumors. Some tumors, such as small cell lung cancer and bronchial carcinoid, can be adrenocorticotropic hormone (ACTH) secreting tumors. Less commonly, parotid acinic cell carcinoma can be ACTH-secreting tumor leading to Cushing’s syndrome. Few literature cases have described ACTH related paraneoplastic syndrome of parotid adenocarcinoma. Because of the rarity of the condition, little is known about the management and prognosis of this phenomenon. In this report, we highlighted the case of a 59-year-old male with a past medical history of parotid adenocarcinoma treated with surgery, chemotherapy, and radiation therapy presented with clinical and biochemical signs of hyperaldosteronism. Abdominal ultra-sound, computed tomography, and magnetic resonance imaging showed hepatic mass. Liver biopsy with immunohistochemistry confirmed the presence of parotid adenocarcinoma secreting ACTH. He is on paclitaxel and carboplatin medication with good clinical response.

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“…Metastasis tends to occur through hematogenous rather than lymphatic pathways, and commonly affects the lungs, bones, liver, and other visceral organs [1,[14][15][16]. Along with increasing the complexity of (or precluding) complete surgical management, metastatic ACC has rarely also been associated with paraneoplastic syndromes such as ectopic adrenocorticotropin hormone (ACTH) release [17,18] with significantly increased morbidity and mortality. Intracranial metastasis is thought to be exceedingly rare and only reported a few times in the medical literature (as presented in our Results section).…”

Section: Discussionmentioning

confidence: 99%

Parotid Acinic Cell Carcinoma with Intracranial Metastasis: A Case Report and Literature Review

F¹,

Bayard²,

Hilda³

et al. 2022

J Head Neck Surg

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Introduction: Acinic cell carcinoma is a rare salivary gland neoplasm frequently associated with local recurrence. While distal metastasis occurs in approximately 19% of cases, intracranial metastasis has been rarely reported in the literature and both preoperative patient characteristics and postoperative prognoses are not currently well-characterized. Methods:In this study, we conducted a systematic review of all relevant studies in the Pubmed database and presented a case series of salivary gland acinic cell carcinomas with intracranial metastasis found in the literature. All relevant studies were reviewed, and information related to the number of patient(s) described, their sex and age, presenting symptoms, location of metastasis, treatment, and time intervals from initial diagnosis and intracranial metastasis and from treatment for intracranial metastasis to last reported follow-up were recorded.Results: Seven studies matching the inclusion criteria were included for data collection and further analysis. The mean age of presentation was 48.9 ± 11.9 years, with intracranial metastasis occurring, on average, 8.7 ± 10.3 years following the initial diagnosis of acinic cell carcinoma. All patients with reported treatment modalities received either surgical resection and/or radiation therapy. The minimum postoperative follow-up for these patients occurred at 11 months, with no postoperative deaths reported in any cases previously published in the literature. Conclusion:Parotid acinic cell carcinoma is a frequently recurring salivary gland neoplasm with metastatic potential, often many years following initial diagnosis. Though intracranial metastasis has only rarely been reported in the literature and associated with increased management complexity, patients demonstrate a positive prognosis following treatment.

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Ectopic ACTH Secretion Secondary to Metastatic Acinic Cell Carcinoma of the Parotid Gland: A Case Report and Review of Current Evidence for Systemic Therapy

Cited by 5 publications

References 20 publications

Change of Levels of NGF, ACTH, and AVP in the Cerebrospinal Fluid after Decompressive Craniectomy of Craniocerebral Injury and Their Relationship with Communicating Hydrocephalus

Change of Levels of NGF, ACTH, and AVP in the Cerebrospinal Fluid after Decompressive Craniectomy of Craniocerebral Injury and Their Relationship with Communicating Hydrocephalus

ACTH-secreting parotid acinic cell carcinoma unusually reported as a paraneoplastic syndrome

Parotid Acinic Cell Carcinoma with Intracranial Metastasis: A Case Report and Literature Review

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