Ecological Risk Assessment of Endocrine Disruptors

Hutchinson, Thomas H.; Brown, Rick; Brugger, Kristin E.; Campbell, Pamela M.; Holt, Martin; Lange, Reinhard; McCahon, Peter; Tattersfield, Lisa J.; Egmond, Roger van

doi:10.2307/3434950

Cited by 19 publications

(22 citation statements)

References 34 publications

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“…Such compounds, defined as endocrine disrupting compounds (EDCs), are in fact able to mimic or antagonize the effects of 0956-5663/$ -see front matter © 2004 Elsevier B.V. All rights reserved. doi:10.1016/j.bios.2004.10.018 endogenous hormones such as estrogens and androgens (Daston et al, 2003;Hutchinson et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

A new recombinant cell-based bioluminescent assay for sensitive androgen-like compound detection☆

Michelini

Leskinen

Virta

et al. 2005

Biosensors and Bioelectronics

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Section: Introductionmentioning

confidence: 99%

A new recombinant cell-based bioluminescent assay for sensitive androgen-like compound detection☆

Michelini

Leskinen

Virta

et al. 2005

Biosensors and Bioelectronics

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“…Within Europe, attention has focussed more on evaluating the environmental risk, through activities of the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) which established the Environmental Estrogens Task Force [44]. This group has reviewed the EDSAC proposals [43], in particular with respect to the scientific rationale and ethical use of animals for ecotoxicity assessment [41].…”

Section: Discussionmentioning

confidence: 99%

In-vitro assays for determination of oestrogenic activity

Scrimshaw

Lester

2004

Analytical and Bioanalytical Chemistry

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At present, in-vitro bioassays are predominantly being seen as tools to identify, through screening programs, whether or not individual chemical compounds have an effect on the endocrine system. However, as the techniques mature, they are likely to find use in the future in monitoring of discharges to the environment for any biological effect and will compliment the range of chemical and biological techniques also available for monitoring environmental quality. Such an approach has already been utilised by a number of workers to fractionate mixtures (e.g. final effluents from STW), to isolate the oestrogenically active components and subsequently identify the compounds which are active. This paper reviews the present state of in-vitro techniques for determination of oestrogenic activity and discusses present approaches to their use in environmental monitoring in conjunction with chemical analyses in toxicity identification and evaluation.

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“…In order to gain a basic understanding of the ecological effects, many research groups are currently testing the environmental impact of toxic pollutants using aquatic invertebrates (Hutchinson et al, 2000;Hutchinson, 2002). Small zooplankton such as mysids, rotifers, cladocerans and copepods are of particular interest since they are ecologically important and their short life cycles allow to obtain information on life-cycle (Yan et al, 2000;Hutchinson, 2002;Hitchcock et al, 2003;Ghekiere et al, 2007).…”

Section: Cultivation Proceduresmentioning

confidence: 99%

A multi-generation Schmakeria poplesia culturing system for use in ecotoxicological study

Huang

Zhu

Qiu

et al. 2009

J. Ocean Univ. China

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Crustacean zooplankton form the keystone link between primary producers and fish stocks in marine and estuary ecosystems. We have established a multi-generation cultivation system for zooplankton with which future experiments on the biological effects of pollutants in marine and estuary environments can be better performed. A population of calanoid copepod, Schmakeria poplesia, was collected in December 2003 and maintained in a static system through all stages (eggs to adults). The population exhibited an average developmental time of 13.6 d in conditions corresponding to the natural environment (water temperature 20℃ , salinity 15). A series of experiments were performed to examine copepod egg production and hatching success as functions of food type and feeding concentration. Results in our study showed that Isochrysis galbana was more favored for the reproduction of copepods than Phaeodactylum tricornutum, and 10×10 4 cells mL -1 was the most practical algae concentration. We have demonstrated that the Schmakeria poplesia population can be maintained in the laboratory through multiple generations. In addition, methods to control egg production through changes in food concentration have been established, making it feasible to control the start date of exposure experiments or the timing of the collection of offspring to initiate a new generation.

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Ecological Risk Assessment of Endocrine Disruptors

Cited by 19 publications

References 34 publications

A new recombinant cell-based bioluminescent assay for sensitive androgen-like compound detection☆

A new recombinant cell-based bioluminescent assay for sensitive androgen-like compound detection☆

In-vitro assays for determination of oestrogenic activity

A multi-generation Schmakeria poplesia culturing system for use in ecotoxicological study

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