Ecologic principles and antibiotic therapy in chronic dermatoses

Leyden, James J.

doi:10.1001/archderm.107.2.208

Cited by 7 publications

(2 citation statements)

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“…The latter should not be relegated to a secondary position on this account. There are more and more examples of ecological disruptions in which a temporary benefit from an antibiotic was followed by relapse owing to overgrowth of resistant species (7,8 It hardly needs to be said that models are merely surrogates. In the last analysis, efficacy must be checked in circumstances that conform more exactly to reality.…”

Section: Discussionmentioning

confidence: 99%

Methods for Evaluating Topical Antibacterial Agents on Human Skin

Marples

Kligman

1974

Antimicrob Agents Chemother

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Three procedures were presented for appraising the ability of antibacterial chemicals and formulations to suppress the growth of microorganisms on human skin. In each of these, the microflora was quantified after the skin had been occlusively covered for a day or more, a circumstance which, in the absence of a deterrent, led to an explosive overgrowth by resident organisms. The data obtained related to (i) the capacity to prevent expansion of the normal microflora, (ii) the suppression of an already expanded flora, and (iii) the persistence of antibacterial effect 3 days after the last application.

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Section: Discussionmentioning

confidence: 99%

Methods for Evaluating Topical Antibacterial Agents on Human Skin

Marples

Kligman

1974

Antimicrob Agents Chemother

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“…A more profitable approach has been to investigate the normal functioning of the system in uivo, and to observe the consequences of natural or experimentally induced perturbations to the system, including the effects of puberty (Leyden et al, 1975), the introduction of natural antibiotic-producing bacteria (Aly et al, 1974) and the application of selective antibiotics (Leyden & Marples, 1973). Again, however, there is a limit to the type of probe used to investigate the functional relationships of the component species, and to the type of perturbation that can be used in oiuo.…”

Section: Introductionmentioning

confidence: 99%