2020 DOI: 10.20944/preprints202008.0389.v1 View full text Preprint
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Amna Khan, Sidra Khalid, Adnan Khan, Bushra Shal, Eunwoo Kang, Hwaryeong Lee, Eun Kyoung Seo, Salman Khan

Abstract: 7β-(3-ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone (ECN), a sesquiterpenoid obtained from a natural origin (Tussilago farfara)has proved to be effective in minimizing various side effects associated with opioids and nonsteroidal anti-inflammatory drugs. The current study focused on investigating the effects of ECN on neuropathic pain induced by partial sciatic nerve ligation (PSNL) by mainly focusing on oxidative stress, inflammatory and apoptotic proteins e…

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