ECM remodeling in hypertensive heart disease

Berk, Bradford C.; Fujiwara, Keigi; Lehoux, Stéphanie

doi:10.1172/jci31044

Cited by 772 publications

(619 citation statements)

References 81 publications

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“…In fact, beyond a significant elevation in blood pressure (both SBP and DBP), HFD rats had an increased perivascular CT in the myocardium. This finding corroborates a previous report that relates hypertension to cardiac fibrosis (Berk et al 2007) and contrasts well with the findings in ER rats, where the lowest BW, blood pressures, and myocardium CT content were verified. Still, they showed an agerelated trend too.…”

Section: Discussionsupporting

confidence: 90%

Energy restriction ameliorates metabolic syndrome-induced cavernous tissue structural modifications in aged rats

Tomada

Fernandes

Guimarães

et al. 2012

AGE

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High-fat (HF) diet regular intake along life highly contributes to vascular dysfunction and to an increment in prevalence of metabolic syndrome (MetS) and erectile dysfunction (ED), a surrogate symptom of occult vascular disease, in the elderly. However, little is known about the effects of energy restriction (ER) alone/or after an HF-feeding period. We show here that in male Sprague-Dawley rats, 16 months of HF-diet consumption led to an increase in body adiposity, blood pressure, lipidemia, C-reactive protein, and insulin resistance and to hypoadiponectinemia, conditions that cluster in MetS. In addition, this treatment strongly favored collagen deposition in cavernous tissue and myocardium. Conversely, for the same time period, the ingestion of 75 % of ad libitum energy intake by controls (ER) extensively counteracted these outcomes. The impact of 6-month ER after 10-month HF period was also analyzed, and despite the decrease in body weight, adiposity, blood pressure, lipidemia, and Creactive protein and improvement of insulin sensitivity, no differences were observed either in adiponectin blood levels or in retroperitoneal fat pad mass. Moreover, this treatment led to a reduction in cavernous tissue collagen deposition, but not in the myocardium, and evidenced differential mobilization of adipose tissue accretions. The data show the ability of HF diet to cause MetS and produce unwanted effects on myocardium and corpora vascular structure. They also indicate that these consequences are preventable upon ER diet starting early, but not later, in life.

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Section: Discussionsupporting

confidence: 90%

Energy restriction ameliorates metabolic syndrome-induced cavernous tissue structural modifications in aged rats

Tomada

Fernandes

Guimarães

et al. 2012

AGE

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“…Dysbalances in MMPs and TIMPs are related to the complex processes of the initiation and progression of both diastolic and systolic heart failure (for review see [42]). In VDR knockout mice, dysregulated MMP/TIMP expression, which was characterized by upregulation of MMP-2 and MMP-9 as well as downregulation of TIMP-1 and TIMP-3, was associated with myocardial fibrosis and hypertrophy [43].…”

Section: Vitamin D Effects On Extracellular Matrix Turnovermentioning

confidence: 99%

Vitamin D deficiency and myocardial diseases

Pilz

Tomaschitz

Drechsler

et al. 2010

Molecular Nutrition Food Res

117

141

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Vitamin D deficiency is common among patients with myocardial diseases because sun-induced vitamin D production in the skin and dietary intake of vitamin D is often insufficient. Knockout mice for the vitamin D receptor develop myocardial hypertrophy and dysfunction. It has also been shown that children with rickets who suffered from severe heart failure could be successfully treated with supplementation of vitamin D plus calcium. In adults, almost all patients with heart failure exhibit reduced 25-hydroxyvitamin D levels, which are used to classify the vitamin D status. In prospective studies, vitamin D deficiency was an independent risk factor for mortality, deaths due to heart failure and sudden cardiac death. Several vitamin D effects on the electrophysiology, contractility, and structure of the heart suggest that vitamin D deficiency might be a causal factor for myocardial diseases. Data from interventional trials, however, are rare and urgently needed to elucidate whether vitamin D supplementation is useful for the treatment of myocardial diseases. In our opinion, the current knowledge of the beneficial effects of vitamin D on myocardial and overall health strongly argue for vitamin D supplementation in all vitamin D-deficient patients with or at high risk for myocardial diseases.

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“…During wound repair and certain pathologies, changes occur in the composition of the ECM, providing signals to the cells that mediate repair or if misregulated, can result in development of various pathologies (Berk et al 2007;Darby and Hewitson 2007;Grzesik and Narayanan 2002;Midwood et al 2004;Raines 2000). In 2000, Paul Bornstein proposed that there was a family of secreted ECM proteins that could be linked through their common functionality.…”

Section: Introductionmentioning

confidence: 99%

Functional role of periostin in development and wound repair: implications for connective tissue disease

Hamilton

2008

Journal of Cell Communication and Signaling

173

184

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Integrity of the extracellular matrix (ECM) is essential for maintaining the normal structure and function of connective tissues. ECM is secreted locally by cells and organized into a complex meshwork providing physical support to cells, tissues, and organs. Initially thought to act only as a scaffold, the ECM is now known to provide a myriad of signals to cells regulating all aspects of their phenotype from morphology to differentiation. Matricellular proteins are a class of ECM related molecules defined through their ability to modulate cell–matrix interactions. Matricellular proteins are expressed at high levels during development, but typically only appear in postnatal tissue in wound repair or disease, where their levels increase substantially. Members of the CCN family, tenascin‐C, osteopontin, secreted protein acidic rich in cysteine (SPARC), bone sialoprotein, thrombospondins, and galectins have all been classed as matricellular proteins. Periostin, a 90 kDa secreted homophilic cell adhesion protein, was recently added to matricellular class of proteins based on its expression pattern and function during development as well as in wound repair. Periostin is expressed in connective tissues including the periodontal ligament, tendons, skin and bone, and is also prominent in neoplastic tissues, cardiovascular disease, as well as in connective tissue wound repair. This review will focus on the functional role of periostin in tissue physiology. Fundamentally, it appears that periostin influences cell behaviour as well as collagen fibrillogenesis, and therefore exerts control over the structural and functional properties of connective tissues in both health and disease. Periostin is a novel matricellular protein with close homology to Drosophila fasciclin 1. In this review, the functional role of periostin is discussed in the context of connective tissue physiology, in development, disease, and wound repair.

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ECM remodeling in hypertensive heart disease

Cited by 772 publications

References 81 publications

Energy restriction ameliorates metabolic syndrome-induced cavernous tissue structural modifications in aged rats

Energy restriction ameliorates metabolic syndrome-induced cavernous tissue structural modifications in aged rats

Vitamin D deficiency and myocardial diseases

Functional role of periostin in development and wound repair: implications for connective tissue disease

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