Echothiophate Iodide Therapy in Children

The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs

“…A decline in AChE levels is well established in humans following treatment with AChE‐inhibiting eye drops 13–15 . Our similar findings in dogs were not surprising considering the many anecdotal reports of systemic side effects in the veterinary ophthalmic literature 4,7 , 16,17 .…”

“…A decline in AChE levels is well established in humans following treatment with AChE-inhibiting eye drops. [13][14][15] Our similar findings in dogs were not surprising considering the many anecdotal reports of systemic side effects in the veterinary ophthalmic literature. 4,7,16,17 However, objective documentation of the magnitude of this reduction is important in determining the likelihood of severe, life-threatening side effects.…”

“…AChE rebound has not been reported in studies of AChE levels following application of AChE‐inhibiting eye drops in humans 14 . Echothiophate iodide, another acetylcholinesterase inhibitor, maintains AChE depression in humans throughout the period of application, and AChE does not begin to rise for several days after cessation of treatment 13,14 . These differences may reflect species differences or differences between demecarium and echothiophate.…”

The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs

“…A decline in AChE levels is well established in humans following treatment with AChE‐inhibiting eye drops 13–15 . Our similar findings in dogs were not surprising considering the many anecdotal reports of systemic side effects in the veterinary ophthalmic literature 4,7 , 16,17 .…”

“…A decline in AChE levels is well established in humans following treatment with AChE-inhibiting eye drops. [13][14][15] Our similar findings in dogs were not surprising considering the many anecdotal reports of systemic side effects in the veterinary ophthalmic literature. 4,7,16,17 However, objective documentation of the magnitude of this reduction is important in determining the likelihood of severe, life-threatening side effects.…”

“…AChE rebound has not been reported in studies of AChE levels following application of AChE‐inhibiting eye drops in humans 14 . Echothiophate iodide, another acetylcholinesterase inhibitor, maintains AChE depression in humans throughout the period of application, and AChE does not begin to rise for several days after cessation of treatment 13,14 . These differences may reflect species differences or differences between demecarium and echothiophate.…”

The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs

“…A decline in AChE levels is well established in humans following treatment with AChE‐inhibiting eye drops 13–15 . Our similar findings in dogs were not surprising considering the many anecdotal reports of systemic side effects in the veterinary ophthalmic literature 4,7 , 16,17 .…”

“…A decline in AChE levels is well established in humans following treatment with AChE-inhibiting eye drops. [13][14][15] Our similar findings in dogs were not surprising considering the many anecdotal reports of systemic side effects in the veterinary ophthalmic literature. 4,7,16,17 However, objective documentation of the magnitude of this reduction is important in determining the likelihood of severe, life-threatening side effects.…”

“…AChE rebound has not been reported in studies of AChE levels following application of AChE‐inhibiting eye drops in humans 14 . Echothiophate iodide, another acetylcholinesterase inhibitor, maintains AChE depression in humans throughout the period of application, and AChE does not begin to rise for several days after cessation of treatment 13,14 . These differences may reflect species differences or differences between demecarium and echothiophate.…”

The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs

“…A decline in AChE levels is well established in humans following treatment with AChE‐inhibiting eye drops 13–15 . Our similar findings in dogs were not surprising considering the many anecdotal reports of systemic side effects in the veterinary ophthalmic literature 4,7 , 16,17 .…”

“…A decline in AChE levels is well established in humans following treatment with AChE-inhibiting eye drops. [13][14][15] Our similar findings in dogs were not surprising considering the many anecdotal reports of systemic side effects in the veterinary ophthalmic literature. 4,7,16,17 However, objective documentation of the magnitude of this reduction is important in determining the likelihood of severe, life-threatening side effects.…”

“…AChE rebound has not been reported in studies of AChE levels following application of AChE‐inhibiting eye drops in humans 14 . Echothiophate iodide, another acetylcholinesterase inhibitor, maintains AChE depression in humans throughout the period of application, and AChE does not begin to rise for several days after cessation of treatment 13,14 . These differences may reflect species differences or differences between demecarium and echothiophate.…”