Echogenicity of the Common Carotid Artery Intima–Media Complex in Stroke

Aizawa, Kunihiko; Elyas, Salim; Adingupu, Damilola D.; Casanova, Francesco; Shore, Angela C.; Strain, W. David; Gates, Phillip E.

doi:10.1016/j.ultrasmedbio.2016.01.006

Cited by 7 publications

(9 citation statements)

References 27 publications

(24 reference statements)

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“…Among them, Figure 7 is a scanned image of a noninvasive cerebral blood vessel after adding a contrast agent. Figure 8 is an image of an ischemic cerebral blood vessel obtained by an edge extraction algorithm [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Three-Dimensional Reconstruction of Cerebrovascular and Algorithm Realization

Jia

2021

Journal of Healthcare Engineering

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Objective. In the three-dimensional reconstruction of CT cerebrovascular medical image registration, a new optimization algorithm based on the relative position information between the contours of various blood vessels in the image is proposed. Methods. Using the rule that the center of gravity of the vascular tissue structure on the series of slices has continuity, find the registration relationship between the contours of the vessels in the two adjacent slices. Because the shape of cerebrovascular contour is relatively symmetrical, its center of gravity is slightly away from its geometric center. Therefore, the geometric center is used to replace the center of gravity, and the “mass” of each contour is calculated according to the area of each contour to achieve the registration of the blood vessel contour. Results. The method has the characteristics of global optimization and stronger robustness. Conclusion. The cerebrovascular image obtained by this method is more realistic and can be used for the import of various software, simulation training, and later research, which provides an effective method for preoperative simulation of cerebrovascular intervention surgery.

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Section: Discussionmentioning

confidence: 99%

Three-Dimensional Reconstruction of Cerebrovascular and Algorithm Realization

Jia

2021

Journal of Healthcare Engineering

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“…12 IM-GSM has also been reported to be a strong correlate of stroke. 22 A casecohort study from the Multi-Ethnic Study of Atherosclerosis (MESA) reported no significant association between IM-GSM and CHD, stroke, and CVD after controlling for CVD risk factors. 23 Taken together, data indicate that IM-GSM is a reliable indicator of subclinical atherosclerosis above and beyond CIMT and more importantly, IM-GSM is strongly associated with stroke and predictive of all-cause mortality.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Cardiovascular Disease Risk Factors Between 2 Subclinical Atherosclerosis Measures in Healthy Postmenopausal Women

Karim

Kono

et al. 2022

J of Ultrasound Medicine

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Objectives-Although carotid artery intima media thickness (CIMT) is a widely used determinant of subclinical atherosclerosis, gray-scale median of the intima-media complex (IM-GSM) of the common carotid artery is a relatively novel measure of echogenicity reflecting composition of the arterial wall. It is important to compare cardiovascular disease (CVD) risk factor correlates across CIMT and IM-GSM to determine whether these measures reflect distinct aspects of atherosclerosis.Methods-Baseline information from a completed randomized clinical trial of 643 healthy postmenopausal women without clinically apparent CVD was included in this cross-sectional study. The women were on average AE SD 61 AE 7 years old, and predominantly non-Hispanic White. CIMT and IM-GSM were measured by high-resolution B-mode ultrasonogram in the far wall of the right common carotid artery. CVD risk factors including age, race, body mass index (BMI), smoking, weekly hours of physical activity, systolic (SBP) and diastolic blood pressure (DBP), lipids, glucose, and inflammatory markers were measured at baseline. Linear regression models were used to assess associations of CVD risk factors with CIMT and IM-GSM. Multivariable models included groups of risk factors added one at a time with and withoutbasic demographic factors (age, race, BMI, physical activity) with model R 2 values compared between CIMT and IM-GSM.Results-In multivariable analysis, age, Black race, BMI, SBP, and DBP were associated with CIMT (all P < .05), whereas age, Hispanic race, BMI, SBP, physical activity, LDL-cholesterol, and leptin were correlates of IM-GSM (all P < .05). Adjusted for age, race, BMI, and physical activity, the R 2 value for SBP was greater for CIMT association, whereas R 2 values for lipids, glucose, inflammatory markers, and adipokines were greater for IM-GSM associations.Conclusions-CIMT and IM-GSM assess different attributes of subclinical atherosclerosis. Integrating both measures may provide improved assessment of atherosclerosis in asymptomatic individuals.

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“…The common carotid arteries were assessed non-invasively using a Doppler ultrasound machine with a high-resolution linear array transducer (SSD-5500 SV, Aloka, Tokyo, Japan) previously described elsewhere [ 25 ]. Briefly, subjects lay supine on an examination bed with the head turned ~45° away from the examined side.…”

Section: Methodsmentioning

confidence: 99%

Cerebral small vessel disease, systemic vascular characteristics and potential therapeutic targets

Elyas

Adingupu

Aizawa

et al. 2021

Aging

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Introduction: Cerebral small vessel disease (SVD) is prevalent in the elderly population and is associated with increased risk of dementia, stroke and disability. Currently there are no clear targets or strategies for the treatment of cerebral SVD. We set out to identify modifiable vascular treatment targets. Patients and Methods: 112 participants with and without a history of CVD underwent macrovascular, microvascular and endothelial function tests and an MRI head scan. Results: Increased carotid intima media thickness and carotid-femoral pulse wave velocity were associated with cerebral WMH (β=1·1 p=0·001 and β=1·66, p<0·0001 respectively). Adjusted cerebral resistance index (p=0·03) and brachial flow mediated dilation time to peak (p=0·001) were associated with the severity of cerebral WMH independent of age and sex. Post occlusive reactive hyperaemia time as a measure of microvascular reactivity was associated with WMH after adjustment for age and sex (p=0·03). Ankle Brachial Pressure Index and urinary albumin excretion rate predicted the severity of cerebral WMH (p=0·02 and 0·01 respectively). Age and hypertension were the most important risk factors for WMH severity (p< 0·0001). Discussion: In addition to hypertension, microalbuminuria, arterial stiffness, vascular reactivity and cerebrovascular resistance could be potential treatment targets to halt the development or progression of cerebral SVD.

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Echogenicity of the Common Carotid Artery Intima–Media Complex in Stroke

Cited by 7 publications

References 27 publications

Three-Dimensional Reconstruction of Cerebrovascular and Algorithm Realization

Three-Dimensional Reconstruction of Cerebrovascular and Algorithm Realization

Comparison of Cardiovascular Disease Risk Factors Between 2 Subclinical Atherosclerosis Measures in Healthy Postmenopausal Women

Cerebral small vessel disease, systemic vascular characteristics and potential therapeutic targets

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