Echocardiographic analysis of regional and global left ventricular shape in chagas’ cardiomyopathy

Patel, Ayan R.; Lima, Carlos Oliveira; Parro, Adelino; Arsenault, Marie; Vannan, ManiA; Pandian, NatesaG

doi:10.1016/s0002-9149(98)00316-6

Cited by 29 publications

(15 citation statements)

References 15 publications

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“…Endocardial curvature and global shape evaluated by Fourier analysis of LV 2-dimensional echocardiograms 36 disclosed a significantly decreased apical curvature with a more spherical LV, resulting in a disruption of the optimal global prolateellipsoid shape even in patients with relatively preserved LV volumes. This finding may suggest that early segmental lesions may progress to diffuse hypokinesis and increased LV end-diastolic dimensions as found in advanced disease.…”

Section: Echocardiographic and Doppler Findings Anatomic Abnormalitiesmentioning

confidence: 99%

Echocardiography in Chagas Heart Disease

2007

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Background-Chagas heart disease is a frequent cause of morbidity and mortality in Latin America. Echocardiography provides useful diagnostic and prognostic information and is an important tool in the management of patients with Chagas disease. Methods and Results-A search for relevant publications was obtained from MEDLINE, LILACS, and SCIELO sources.Acute Chagas myocarditis is a rare disorder in which pericardial effusion is frequent. Echocardiography may exclude pericardial tamponade in case of heart failure. Chronic Chagas cardiomyopathy evolves for several decades after the infection. Epidemiological history, positive serology, and suggestive clinical and ECG abnormalities establish the diagnosis. About three quarters of chronic Chagas cardiomyopathy subjects remain asymptomatic with normal (indeterminate form) or abnormal ECGs. Early Doppler abnormalities includes prolongation of isovolumic contraction and relaxation times. Systolic function frequently is normal, but dysfunction may be elicited by stress tests. Half or more of symptomatic patients have a left ventricular apical aneurysm and other segmental contractile abnormalities similar to those seen in coronary heart disease. The dilated nonsegmental form is indistinguishable from dilated cardiomyopathy. Results from univariate and multivariate Cox survival analyses indicate that impaired systolic function and increased ventricular dimensions have significant value in predicting cardiac morbidity and mortality. Cardiac ultrasound commonly is used in the follow-up of patients and in the assessment of various therapeutic modalities. Conclusions-Echocardiographic and Doppler techniques provide useful structural and functional information in the detection of early myocardial damage, risk assessment of prognosis, disease progression, and management of patients with Chagas disease.

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Section: Echocardiographic and Doppler Findings Anatomic Abnormalitiesmentioning

confidence: 99%

Echocardiography in Chagas Heart Disease

2007

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“…conduction system and structural-functional situation of the left ventricle, respectively of a specific cardiomyopathy in which left ventricular relaxation can be often identified as the earliest alteration [30]. Hence, both tests should be routinely carried out at the moment of diagnosis [31].…”

Section: Discussionmentioning

confidence: 99%

Clinical, electrocardiographic and echocardiographic abnormalities in Latin American migrants with newly diagnosed Chagas disease 2005-2009, Barcelona, Spain

et al. 2011

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“…This is despite several studies indicating that LV shape analysis may be potentially useful and could be used in conjunction with different imaging modalities, including radionuclide ventriculography [8,9], electron beam computed tomography [10] and ultrasound images [11][12][13][14]. Moreover, LV function has been studied both on a global and regional basis, but previous studies have focused on global LV shape, while only initial feasibility data have been published regarding local LV shape [14,15]. A new technique was recently proposed for global LV shape analysis from real-time three-dimensional (3D) echocardiographic images [16], which was able to demonstrate independent changes in LV volume and shape as well as to identify differences between normal and abnormal ventricles.…”

Section: Introductionmentioning

confidence: 99%

“…While a variety of techniques for quantitative evaluation of LV volume have become part of standard clinical practice [1][2][3], the development of tools for quantitative evaluation of ventricular shape has been explored only partially [4][5][6][7]. This is despite several studies indicating that LV shape analysis may be potentially useful and could be used in conjunction with different imaging modalities, including radionuclide ventriculography [8,9], electron beam computed tomography [10] and ultrasound images [11][12][13][14]. Moreover, LV function has been studied both on a global and regional basis, but previous studies have focused on global LV shape, while only initial feasibility data have been published regarding local LV shape [14,15].…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional analysis of regional left ventricular endocardial curvature from cardiac magnetic resonance images

Maffessanti

Lang

Niel

et al. 2011

Magnetic Resonance Imaging

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Purpose: Left ventricular (LV) remodeling is usually assessed using global changes in LV volume. We hypothesized that threedimensional analysis of regional endocardial curvature from magnetic resonance images could provide clinically useful information on localized LV remodeling. We tested this approach by investigating regional differences in endocardial curvature in normal and hypokinetic ventricles. Materials and Methods: Images were obtained in 44 patients with normal LV function (NL, N=14), dilated cardiomyopathy (DCM, N=15) or ischemic heart disease (IHD, N=15). Local surface curvedness, normalized to take into account instantaneous LV size (C n ), was calculated throughout the cardiac cycle and compared between segment groups: NL (N=401), IHD (N=92) and DCM (N=255). Results: In all normal segments, C n gradually increased during systole and then decreased during diastole. While both maximum and minimum values of C n were comparable in the basal and midventricular segments, they were significantly higher in the four apical segments and highest in the apical cap. In addition, percent change in C n was higher in mid and apical compared to basal segments (Pb.05). At all LV levels, C n values in DCM segments were lower (Pb.05) than in NL and IHD segments, which were similar. In contrast, percent change in C n was significantly lower in both IHD and DCM segments compared to NL. Conclusion: Three-dimensional analysis of LV endocardial curvature yielded quantitative information on regional ventricular shape consistent with the known pathophysiology, supporting its potential clinical usefulness in the evaluation of LV remodeling.

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Echocardiographic analysis of regional and global left ventricular shape in chagas’ cardiomyopathy

Cited by 29 publications

References 15 publications

Echocardiography in Chagas Heart Disease

Echocardiography in Chagas Heart Disease

Clinical, electrocardiographic and echocardiographic abnormalities in Latin American migrants with newly diagnosed Chagas disease 2005-2009, Barcelona, Spain

Three-dimensional analysis of regional left ventricular endocardial curvature from cardiac magnetic resonance images

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