Ecdysteroids from Chenopodium quinoa Willd., an ancient Andean crop of high nutritional value

Kumpun, Saowanee; Maria, Annick; Crouzet, Sophie; Evrard‐Todeschi, Nathalie; Girault, Jean‐Pierre; Lafont, René

doi:10.1016/j.foodchem.2010.10.039

Cited by 79 publications

(87 citation statements)

References 23 publications

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“…3. The fragmentation patterns for the steroidal compounds are in accordance with the key fragmentation described for ecdysteroids (Kumpun et al, 2011;Stevens, Reed, & Morré, 2008;Wang et al, 2008) compound 2, the same fragmentation related to the loss of water was observed, being identified as 20-hydroxyecdysone. The constituents ecdysone and 20-hydroxyecdysone, among other derivatives, were found in S. rhombifolia and S. spinosa (Darwish & Reinecke, 2003;Dinan et al, 2001).…”

Section: Lc-esi-mssupporting

confidence: 76%

Ecdysteroids in Sida tuberculata R.E. Fries (Malvaceae): Chemical composition by LC–ESI-MS and selective anti-Candida krusei activity

Rosa

Camargo

et al. 2015

Food Chemistry

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Section: Lc-esi-mssupporting

confidence: 76%

Ecdysteroids in Sida tuberculata R.E. Fries (Malvaceae): Chemical composition by LC–ESI-MS and selective anti-Candida krusei activity

Rosa

Camargo

et al. 2015

Food Chemistry

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“…1C), which also corroborated the MS/MS spectrum of its Girard T derivative. Indeed, 24(28)-dehydromakisterone (dhMaA) has been identified in plants (Báthori et al, 1999;Kumpun et al, 2011;Thuy et al, 1998); however, to the best of our knowledge it has not been found in insects. A reference sample of dhMaA purified from plants (Báthori et al, 1999;Wessner et al, 1992) matched the retention time and MS/MS spectrum of the Drosophila ecdysteroid (data not shown).…”

Section: The Composition Of the Drosophila Ecdysteroidomementioning

confidence: 99%

The Ecdysteroidome of Drosophila: influence of diet and development

et al. 2015

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Ecdysteroids are the hormones regulating development, physiology and fertility in arthropods, which synthesize them exclusively from dietary sterols. But how dietary sterol diversity influences the ecdysteroid profile, how animals ensure the production of desired hormones and whether there are functional differences between different ecdysteroids produced in vivo remains unknown. This is because currently there is no analytical technology for unbiased, comprehensive and quantitative assessment of the full complement of endogenous ecdysteroids. We developed a new LC-MS/MS method to screen the entire chemical space of ecdysteroid-related structures and to quantify known and newly discovered hormones and their catabolites. We quantified the ecdysteroidome in Drosophila melanogaster and investigated how the ecdysteroid profile varies with diet and development. We show that Drosophila can produce four different classes of ecdysteroids, which are obligatorily derived from four types of dietary sterol precursors. Drosophila makes makisterone A from plant sterols and epi-makisterone A from ergosterol, the major yeast sterol. However, they prefer to selectively utilize scarce ergosterol precursors to make a novel hormone 24,28-dehydromakisterone A and trace cholesterol to synthesize 20-hydroxyecdysone. Interestingly, epi-makisterone A supports only larval development, whereas all other ecdysteroids allow full adult development. We suggest that evolutionary pressure against producing epi-C-24 ecdysteroids might explain selective utilization of ergosterol precursors and the puzzling preference for cholesterol.

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“…which are not natural phytoecdysteroids) could form the basis for a test for the consumption of large amounts of ecdysteroids [16,17]. Levels of ecdysteroids in a normal western diet are low (usually in the range of less than 1 mg/day [47]), unless eating large amounts of spinach or quinoa [48], whereas doses 'recommended" for bodybuilders are in the range of 100-1000 mg/day [4,5,7].…”

Section: Possible Relations Of This Metabolism To the Pharmacologicalmentioning

confidence: 99%

The metabolism of 20-hydroxyecdysone in mice: Relevance to pharmacological effects and gene switch applications of ecdysteroids

Kumpun

Girault

Dinan

et al. 2011

The Journal of Steroid Biochemistry and Molecular Biology

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Ecdysteroids from Chenopodium quinoa Willd., an ancient Andean crop of high nutritional value

Cited by 79 publications

References 23 publications

Ecdysteroids in Sida tuberculata R.E. Fries (Malvaceae): Chemical composition by LC–ESI-MS and selective anti-Candida krusei activity

Ecdysteroids in Sida tuberculata R.E. Fries (Malvaceae): Chemical composition by LC–ESI-MS and selective anti-Candida krusei activity

The Ecdysteroidome of Drosophila: influence of diet and development

The metabolism of 20-hydroxyecdysone in mice: Relevance to pharmacological effects and gene switch applications of ecdysteroids

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